公开(公告)号：US20050255152A1

公开(公告)日：2005-11-17

申请号：US10511413

申请日：2003-04-17

Applicant: David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

Inventor： David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K38/09 ,  A61K38/22 ,  A61K47/48

CPC classification number: A61K31/704 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K47/62 ,  A61K47/6933 ,  B82Y5/00

Abstract: A method and compositions for targeted drug delivery have been developed. The compositions include a targeting molecules such as a hormone that specifically binds to a receptor on the surface of the targeted cells; a drug to be delivered, such as a toxin that will kill the targeted cells; and a nanoparticle, which contains on or within the nanoparticle, the drug to be delivered, as well as has attached thereto, the targeting molecule. Nanoparticles can consist of drug or drug associated with carrier, such as a controlled or sustained release materials like a poly(lactide-co-glycolide), a liposome or surfactant. The compositions are administered by injections in most cases, although compositions can be applied topically orally, nasally, vaginally, rectally, and ocularly. Compositions can also be administered to the pulmonary or respiratory system, most preferably in an aerosol.

Abstract translation: 已经开发了用于靶向药物递送的方法和组合物。 组合物包括靶向分子，例如与靶细胞表面上的受体特异性结合的激素; 待传递的药物，例如将杀死靶细胞的毒素; 以及在纳米颗粒上或内部含有待递送药物以及与其连接的靶向分子的纳米颗粒。 纳米颗粒可以由与载体相关的药物或药物组成，例如受控或持续的释放材料如聚（丙交酯 - 共 - 乙交酯），脂质体或表面活性剂。 组合物在大多数情况下通过注射施用，尽管组合物可以局部地口服，经鼻，阴道，直肠和眼睛施用。 组合物也可以施用于肺或呼吸系统，最优选以气溶胶施用。

公开(公告)号：US20050232872A1

公开(公告)日：2005-10-20

申请号：US11154067

申请日：2005-06-14

Applicant: Daniel Deaver ,  David Edwards

Inventor： Daniel Deaver ,  David Edwards

IPC: A61K47/28 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K38/17 ,  A61K38/22 ,  A61K45/08 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K48/00 ,  A61L9/04

CPC classification number: A61K9/0046 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/06 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K47/38 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  Y10S977/906

Abstract: Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.

公开(公告)号：US08641128B2

公开(公告)日：2014-02-04

申请号：US12537294

申请日：2009-08-07

Applicant: David Edwards

Inventor： David Edwards

IPC: B62D27/02 ,  E04C5/16

CPC classification number: B62D25/2054

Abstract: An insert that can be used support a vehicle floor if a cross member fails either mechanically or through corrosion. The insert may also be used to protect a fastener used in a vehicle floor assembly.

Abstract translation: 如果交叉构件机械地或通过腐蚀失效，则可以使用的插入件支撑车辆底板。 插入件也可用于保护用于车辆地板组件中的紧固件。

公开(公告)号：US08423280B2

公开(公告)日：2013-04-16

申请号：US13572279

申请日：2012-08-10

Applicant: David Edwards ,  David Robert Pavlik ,  Ramkumar Subramanian ,  Robert Martin Coats

Inventor： David Edwards ,  David Robert Pavlik ,  Ramkumar Subramanian ,  Robert Martin Coats

IPC: G06F17/10 ,  B60Q1/00 ,  G01S13/00

CPC classification number: G01S13/931 ,  G01S7/062 ,  G01S13/862 ,  G01S13/865 ,  G01S13/867 ,  G01S13/87 ,  G01S17/023 ,  G01S2013/9332 ,  G01S2013/9353 ,  G01S2013/9364 ,  G01S2013/9367 ,  G01S2013/9389 ,  G08G1/16 ,  G08G1/166 ,  G08G1/167

Abstract: A method for collision avoidance for a machine is disclosed. The method includes detecting an obstacle with an obstacle detection system and generating a corresponding signal. The obstacle detection system includes an operator input device. The method also includes providing an obstacle detection warning in response to the signal. The method further includes determining with a controller whether the operator input device has been activated in response to the obstacle detection warning.

Abstract translation: 公开了一种用于机器的防碰撞的方法。 该方法包括利用障碍物检测系统检测障碍物并产生相应的信号。 障碍物检测系统包括操作员输入装置。 该方法还包括响应于该信号提供障碍物检测警告。 该方法还包括利用控制器确定操作员输入装置是否已经响应于障碍物检测警告被激活。

公开(公告)号：US20080253971A9

公开(公告)日：2008-10-16

申请号：US10420071

申请日：2003-04-18

Applicant: David Edwards ,  Robert Langer ,  Rita Vanbever ,  Jeffrey Mintzes ,  Jue Wang ,  Donghao Chen

Inventor： David Edwards ,  Robert Langer ,  Rita Vanbever ,  Jeffrey Mintzes ,  Jue Wang ,  Donghao Chen

IPC: A61K9/14 ,  A61L9/04 ,  A61K38/00

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/135 ,  A61K31/137 ,  A61K31/566 ,  A61K38/28 ,  A61K38/38 ,  A61K47/12 ,  A61K47/183 ,  A61K47/24 ,  A61K47/6927

Abstract: The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

公开(公告)号：US20080073239A1

公开(公告)日：2008-03-27

申请号：US11844493

申请日：2007-08-24

Applicant: Paul Duffield ,  Geoffrey Hammond ,  David Edwards ,  William McCarthy ,  Arnold Beckett ,  Anthony Jackman

Inventor： Paul Duffield ,  Geoffrey Hammond ,  David Edwards ,  William McCarthy ,  Arnold Beckett ,  Anthony Jackman

IPC: B65D85/808

CPC classification number: C11D17/043 ,  A61G2205/00 ,  A61J3/07 ,  A61J3/071 ,  A61J3/072 ,  A61J3/08 ,  A61K9/4808 ,  A61K9/4816 ,  B29C45/0001 ,  B29C65/02 ,  B29C65/16 ,  B29C65/1612 ,  B29C65/1674 ,  B29C66/21 ,  B29C66/3452 ,  B29C66/54 ,  B29C2035/0822 ,  B29K2027/06 ,  B29K2029/04 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65D1/24 ,  B65D1/30 ,  B65D25/04 ,  B65D51/28 ,  B65D65/46 ,  B65D81/32 ,  B65D81/3205 ,  B65D81/3283 ,  B65D81/3294 ,  C11D11/007 ,  C11D17/042 ,  C11D17/045 ,  Y02W90/12 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1379 ,  Y10T428/1397

Abstract: A rigid, water-soluble container is made of an injection molded poly(vinyl alcohol) and/or a cellulose ether, which container encases a fabric care, surface care or dishwashing composition; and a capsule container comprising at least two components made of one or more material(s) that can be molded and which are water soluble or water dispersible or in which a substantial part of the surface of these components is water soluble or water dispersible so as to leave perforations throughout the wall when the capsular container is placed in contact with an aqueous environment. The container has one to six compartments, preferably one, two or three, the content of the various compartments being accessible to the aqueous environment when the capsular container is exposed to such an aqueous environment. The accessibility time of the various compartments is the same or different from one compartment to another compartment, with the proviso that the content of the container is not a fabric care, surface care or dishwashing composition.

Abstract translation: 刚性的水溶性容器由注射成型的聚（乙烯醇）和/或纤维素醚制成，该容器包含织物护理，表面护理或洗碗组合物; 以及胶囊容器，其包含至少两个由可以模制并且是水溶性或水分散性的一种或多种材料制成的部件，或者这些部件的大部分表面是水溶性或水分散性的，以便 当胶囊容器与水性环境接触时，穿过整个墙壁穿孔。 容器具有一至六个隔室，优选一个，二个或三个，当荚膜容器暴露于这种水性环境时，各种隔室的内容物可接触水溶液环境。 各个隔室的可接近时间与一个隔室相同或不同，另一个隔间是条件，即容器的内容物不是织物护理，表面护理或餐具清洗组合物。

公开(公告)号：US20080038207A1

公开(公告)日：2008-02-14

申请号：US11827031

申请日：2007-07-10

Applicant: David Edwards ,  Mark Gabrielson ,  Robert Clarke ,  Wesley Dehaan ,  Matthew Brande ,  Jonathan Man

Inventor： David Edwards ,  Mark Gabrielson ,  Robert Clarke ,  Wesley Dehaan ,  Matthew Brande ,  Jonathan Man

IPC: A61K31/70 ,  A01N37/18

CPC classification number: A61B5/097 ,  G01N33/497

Abstract: Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

公开(公告)号：US20070216534A1

公开(公告)日：2007-09-20

申请号：US11752482

申请日：2007-05-23

Applicant: Scott Ferguson ,  David Edwards ,  Peikang Liu ,  Jason Munn ,  Ian Forster ,  Samuel Linder ,  Thomas Weakley ,  David Puleston ,  Steven Kennedy ,  Christine Dang

Inventor： Scott Ferguson ,  David Edwards ,  Peikang Liu ,  Jason Munn ,  Ian Forster ,  Samuel Linder ,  Thomas Weakley ,  David Puleston ,  Steven Kennedy ,  Christine Dang

IPC: G08B13/14

CPC classification number: G06K19/07752 ,  G06K19/07745 ,  G06K19/07749 ,  G06K19/07756 ,  H01L2224/16 ,  H01L2924/01046 ,  H01L2924/01079 ,  H01L2924/1461 ,  H01L2924/3011 ,  H01Q1/22 ,  H01Q1/2225 ,  H01Q1/38 ,  H01Q7/00 ,  Y10T29/49124 ,  H01L2924/00

Abstract: A radio frequency identification (RIFD) inlay includes an electrical connection between a chip and an antenna. The electrical connection includes conductive interposer leads and a capacitive connection. The capacitive connection may involve putting the antenna and the interposer leads into close proximity, with dielectric pads therebetween, to allow capacitive coupling between the antenna and the interposer leads. The dielectric pads may include a non-conductive adhesive and a high dielectric material, such as a titanium oxide. The connections provide a convenient, fast, and effective way to operatively couple antennas and interposers. The RFID inlay may be part of an RFID label or RFID tag.

Abstract translation: 射频识别（RIFD）嵌体包括芯片和天线之间的电连接。 电气连接包括导电插入引线和电容连接。 电容连接可能涉及将天线和插入器引线紧密接合，其间具有介电垫，以允许天线和插入器引线之间的电容耦合。 介电垫可以包括非导电粘合剂和高介电材料，例如氧化钛。 这些连接提供了方便，快速和有效的方式来操作地耦合天线和插入器。 RFID嵌体可以是RFID标签或RFID标签的一部分。

公开(公告)号：US20070045819A1

公开(公告)日：2007-03-01

申请号：US11160997

申请日：2005-07-19

Applicant: David Edwards ,  Sushumna Iruvanti ,  Hilton Toy ,  Wei Zou

Inventor： David Edwards ,  Sushumna Iruvanti ,  Hilton Toy ,  Wei Zou

IPC: H01L23/12

CPC classification number: H01L23/04 ,  H01L23/10 ,  H01L23/3675 ,  H01L23/42 ,  H01L24/32 ,  H01L2224/16225 ,  H01L2224/26175 ,  H01L2224/27013 ,  H01L2224/32245 ,  H01L2224/73253 ,  H01L2224/83051 ,  H01L2224/83385 ,  H01L2924/01005 ,  H01L2924/01013 ,  H01L2924/01033 ,  H01L2924/16152 ,  H01L2924/16153 ,  H01L2924/1616 ,  Y10S257/924

Abstract: A semiconductor module structure and a method of forming the semiconductor module structure are disclosed. The structure incorporates a die mounted on a substrate and covered by a lid. A thermal compound is disposed within a thermal gap between the die and the lid. A barrier around the periphery of the die extends between the lid and the substrate, contains the thermal compound, and flexes in response to expansion and contraction of both the substrate and the lid during cycling of the semiconductor module. More particularly, either the barrier is formed of a flexible material or has a flexible connection to the substrate and/or to the lid. The barrier effectively contains the thermal compound between the die and the lid and, thereby, provides acceptable and controlled coverage of the thermal compound over the die for heat removal.

公开(公告)号：US20070021203A1

公开(公告)日：2007-01-25

申请号：US11393244

申请日：2006-03-30

Applicant: David Edwards

Inventor： David Edwards

IPC: A63F9/24

CPC classification number: A63F13/52 ,  A63F13/10 ,  A63F13/12 ,  A63F13/332 ,  A63F13/5375 ,  A63F13/837 ,  A63F2300/203 ,  A63F2300/206 ,  A63F2300/303 ,  A63F2300/307 ,  A63F2300/406 ,  A63F2300/552 ,  A63F2300/6009 ,  A63F2300/66 ,  A63F2300/8076

Abstract: A method of display is provided that includes providing a similar game onto a first and second mobile devices. The game displaying a first portion of a video image on a small display of the first mobile device. The game displaying a second portion of the video image on a larger display of the second mobile device. The second portion wider and higher than the width the height of the first portion. The game allowing a first player of the game on the first mobile device a range of motion of a target indicator on the first mobile device about the height and width of the first portion of the video image. The game allowing a second player of the game on the second mobile device about the same height range of motion of the target indicator as provided on the first mobile device with the smaller display.

Abstract translation: 提供了一种显示方法，其包括在第一和第二移动设备上提供类似的游戏。 游戏在第一移动设备的小显示器上显示视频图像的第一部分。 游戏在第二移动设备的较大显示器上显示视频图像的第二部分。 第二部分宽并且高于第一部分的高度的宽度。 所述游戏允许第一移动设备上的游戏的第一玩家在第一移动设备上关于视频图像的第一部分的高度和宽度的目标指示器的运动范围。 所述游戏允许第二移动设备上的游戏的第二玩家在具有较小显示的第一移动设备上提供与目标指示器相同的高度运动范围。