公开(公告)号：US20240325145A1

公开(公告)日：2024-10-03

申请号：US18739032

申请日：2024-06-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Eran Grosu ,  Michael Bukin ,  Nikolai Gurovich

IPC: A61F2/24

CPC classification number: A61F2/2433 ,  A61F2/2418 ,  A61F2250/001 ,  A61F2250/0098

Abstract: Certain examples of the disclosure concern a prosthetic device. The prosthetic device can include a radially compressible and expandable frame and a screw actuator coupled to the frame and configured to be rotated to radially expand the frame from a radially compressed state to a radially expanded state. The frame can include two or more pairs of first markers and second markers. The pairs of first and second markers can be circumferentially spaced apart from each other. The first and second markers of each pair can be axially aligned and axially movable relative to one another as the frame radially expands. Positions of the first and second markers can be configured so that a difference in axial distances between respective pairs of the first markers and second markers can indicate a degree of evenness of the frame's radial expansion.

公开(公告)号：US20240325143A1

公开(公告)日：2024-10-03

申请号：US18737015

申请日：2024-06-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Alexey Tsypenyuk

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2230/001 ,  A61F2230/006 ,  A61F2250/0039

Abstract: A prosthetic heart valve includes a frame made of a plastically expandable material and including an inflow end, an outflow end, and a central portion between the inflow end and the outflow end. The frame is radially collapsible and expandable. The inflow end includes a plurality of circumferentially extending first strut members having a first strut width and forming a first angle between adjacent first strut members, and the central portion includes a plurality of circumferentially extending second strut members having a second strut width and forming a second angle between adjacent second strut members. A plurality of leaflets is positioned within the frame and configured to regulate blood flow through the prosthetic heart valve. The first strut width of the first strut members at the inflow end of the frame is greater than the second strut width of the second strut members in the central portion of the frame.

公开(公告)号：US20240285398A1

公开(公告)日：2024-08-29

申请号：US18656929

申请日：2024-05-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Elena Sherman ,  Shir Lazovski ,  Ziv Yohanan ,  Nikolai Gurovich ,  Bich Hoang Pham

IPC: A61F2/24

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075

Abstract: A prosthetic heart valve including a plurality of leaflets attached to the frame is disclosed. The plurality of leaflets is disposed within the frame and configured to regulate the flow of blood through the frame in one direction, each leaflet comprising a cusp edge portion. The prosthetic heart valve can further include at least one suture extending along a cusp edge portion of at least a first leaflet of the plurality of leaflets, a plurality of in-and-out stitches extending through the suture and the cusp edge portion of the first leaflet, and a plurality of whip stitches that extend around selected struts of the frame and the suture to couple the cusp edge portion of the first leaflet to the frame.

公开(公告)号：US20240108464A1

公开(公告)日：2024-04-04

申请号：US18536823

申请日：2023-12-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Nikolai Gurovich

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2210/0057 ,  A61F2220/0075

Abstract: A prosthetic heart valve including a radially expandable and compressible annular frame and a plurality of leaflets attached to the frame is disclosed. The frame includes a plurality of interconnected struts defining a plurality of rows of cells arranged between a first end and a second end of the frame, the plurality of interconnected struts comprising a plurality of first struts defining the first end of the frame. The frame further includes a plurality of second struts axially offset from the first end of the frame, each second strut connected to and between two adjacent first struts of the plurality of first struts and extending axially away from the two adjacent first struts, where an inflow end of a cusp edge portion of each leaflet of the plurality of leaflets is secured to a corresponding second strut of the plurality of second struts.

公开(公告)号：US20240024101A1

公开(公告)日：2024-01-25

申请号：US18373892

申请日：2023-09-27

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Nikolai Gurovich ,  Karin Lavon ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0025

Abstract: A prosthetic heart valve including a radially expandable and compressible annular frame is disclosed. The frame includes a plurality of interconnected struts defining a plurality of rows of cells arranged between an inflow end and an outflow end of the frame, the interconnected struts comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further includes a plurality of apex regions formed at the inflow end and the outflow end, each apex region curving between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions. Each apex region has a narrowed width and a length that extends along at least 25% of a total length of the outflow strut or inflow strut, the narrowed width smaller than a width of the two angled strut portions.

公开(公告)号：US20230372093A1

公开(公告)日：2023-11-23

申请号：US18358845

申请日：2023-07-25

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Michael Bukin ,  Nikolai Gurovich ,  Noam Nir ,  Tomer Saar ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2250/0069

Abstract: The present invention relates to implantable prosthetic devices, and more particularly, to 3D-shaped skirts having various coatings and/or configurations thereof.

公开(公告)号：US11690710B2

公开(公告)日：2023-07-04

申请号：US17660394

申请日：2022-04-22

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolai Gurovich ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0039

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US20250090317A1

公开(公告)日：2025-03-20

申请号：US18967404

申请日：2024-12-03

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Eran Grosu ,  Ilan Leshecz

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a valve frame comprising an outflow end and an inflow end, a plurality of leaflets disposed within and coupled to the valve frame, and a skirt assembly mounted to an outer surface of the valve frame. The skirt assembly includes a sealing layer and a skirt frame including a plurality of interconnected struts, wherein the skirt frame has a plurality of inflow apices and outflow apices, wherein selected ones of the inflow apices are fixed to the valve frame and selected ones of the outflow apices are fixed to the valve frame, wherein one or more of the struts are configured to flex in an outward radial direction when the valve frame is in a radially expanded state to cause the sealing layer to protrude outwardly from the valve frame.

公开(公告)号：US20250090311A1

公开(公告)日：2025-03-20

申请号：US18950681

申请日：2024-11-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Gil Senesh ,  Michael Bukin ,  Anatoly Dvorsky ,  Tamir S. Levi ,  Elena Sherman

IPC: A61F2/24 ,  A61F2/00 ,  A61L27/18

Abstract: Outer skirts for a prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include an annular frame and an outer skirt disposed around an outer surface of the frame. The outer skirt can include a first portion comprising a polymeric material and a second portion comprising a fabric, where the polymeric material has a greater thromboresistance than the fabric. The second portion is secured to an inflow end of the frame and extends toward an intermediate portion of the frame and the first portion extends from the second portion and toward an outflow end of the frame

公开(公告)号：US20240423790A1

公开(公告)日：2024-12-26

申请号：US18825316

申请日：2024-09-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Anatoly Dvorsky ,  Michael Bukin ,  Nikolai Gurovich ,  Eran Grosu

IPC: A61F2/24

Abstract: This disclosure is directed to prosthetic heart valves and actuators for prosthetic heart valves. In some examples, the actuator can comprise an internally threaded bore that engages an externally threaded portion of the frame component, such as a stationary post. In some examples, the actuator can comprise an externally threaded end portion that engages an internally threaded bore in a frame component, such as a stationary post.