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31.发明授权
公开(公告)号：US5045532A
公开(公告)日：1991-09-03
申请号：US260067
申请日：1988-10-20
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/715 , A61P25/04 , A61P29/00 , C07H15/10
摘要： A pharmaceutical composition is provided comprising inner ester ganglioside derivatives useful for its peripheral analgesic-antiinflammatory activity in treating pain caused by pathologies of the peripheral nervous system and which can advantageously be administered orally.
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32.发明授权
公开(公告)号：US4940694A
公开(公告)日：1990-07-10
申请号：US338516
申请日：1988-10-20
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/30 , A61P9/00 , A61P25/28 , C07H15/10
CPC分类号： C07H15/10
摘要： A pharmaceutical preparation containing the ganglio-side GM.sub.1 or an inner ester derivative thereof and a method for increasing cerebral blood flow in stroke victims by acute administration of GM.sub.1 or its inner ester derivative.
摘要翻译： 包含神经节GM1或其内酯衍生物的药物制剂和通过急性给药GM1或其内酯衍生物来增加卒中受试者的脑血流量的方法。
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公开(公告)号：US4713374A
公开(公告)日：1987-12-15
申请号：US749092
申请日：1985-06-26
IPC分类号： C07H3/00 , A61K31/70 , A61K31/7028 , A61K31/715 , A61K35/30 , A61P25/00 , C07C68/00 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/10 , C08G18/08 , C08G18/18
CPC分类号： C07H15/10
摘要： New functional ganglioside derivatives comprising ester, amide and peracylated derivatives of gangliosides, preparation procedures therefor, pharmaceutical preparations containing the same, and the therapeutic use of the derivatives.
摘要翻译： 包含神经节苷脂的酯，酰胺和过酰基化衍生物的新功能性神经节苷脂衍生物，其制备方法，含有它们的药物制剂及其衍生物的治疗用途。
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34.发明授权
公开(公告)号：US4593091A
公开(公告)日：1986-06-03
申请号：US425462
申请日：1982-09-28
CPC分类号： C07H19/01
摘要： The present invention relates to a method for preparing inner ester derivatives of gangliosides and pharmaceutical compositions containing such derivatives to be used in treating disorders of the nervous system. The pharmaceutical compositions of the present invention promote nerve regeneration by stimulating nerve sprouting.
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公开(公告)号：US5709877A
公开(公告)日：1998-01-20
申请号：US476569
申请日：1995-06-07
IPC分类号： A61K9/70 , A61K9/06 , A61L15/22 , A61L15/28 , A61L15/44 , C08L5/04 , C08L5/08 , A61K47/36 , A61L15/64
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
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公开(公告)号：US5631241A
公开(公告)日：1997-05-20
申请号：US426905
申请日：1995-04-21
IPC分类号： A61K20060101 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/12 , A61K31/715 , A61K38/18 , A61K45/06 , A61K45/08 , A61K47/26 , A61K47/36 , A61K47/48 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/26 , A61K47/36 , A61K9/0014 , A61K9/0019 , A61K9/0048 , C08B37/0072 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/12 , Y10S514/912
摘要： Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections. In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
摘要翻译： 获得透明质酸的两种药学上可用的级分，其包含分子量在50,000和100,000之间的用于伤口愈合的第一级分，以及分子量在500,000和730,000之间的第二级分，其用于眼内和关节内注射。 此外，提供了用于局部给药的药物制剂，其含有药理活性物质以及透明质酸或其分子量级分。 透明质酸可以是游离酸的形式，或者可以是与碱金属或碱土金属，镁，铝或铵的盐，或者是与一种或多种药理学活性物质形式的盐。
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公开(公告)号：US5523294A
公开(公告)日：1996-06-04
申请号：US89601
申请日：1993-07-12
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, wherein the acyl groups are derived from an aliphatic acid having from 1 to 24 carbon atoms, substituted by one or more polar groups are disclosed. The acyl-di-lysogangliosides of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.
摘要翻译： N-酰基-N，N'-二溶菌索双胍，N'-酰基-N，N'-二溶神经节苷脂和N，N'-二酰基-N，N'-二溶神经节苷脂，其中酰基衍生自 公开了由一个或多个极性基团取代的具有1至24个碳原子的脂族酸。 本发明的酰基二溶神经节苷脂对蛋白激酶C活化具有抑制作用，因此可用于神经系统各种病理学的治疗。 还公开了溶血二糖苷衍生物的药物组合物和治疗用途。
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38.发明授权Gels in the form of highly hydrated self-supporting film, the process for their preparation, and their use in the therapy of cutaneous lesions and/or pathologies 失效高度水合的自支撑膜形式的凝胶，其制备方法及其在治疗皮肤病变和/或病理学中的应用
公开(公告)号：US5523093A
公开(公告)日：1996-06-04
申请号：US707790
申请日：1991-05-30
IPC分类号： A61K9/70 , A61K9/06 , A61L15/22 , A61L15/28 , A61L15/44 , C08L5/04 , C08L5/08 , A61K47/36 , A61L15/64
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
摘要翻译： 本发明提供了高度水合的自支撑膜形式的新凝胶，其包含一种或多种亲水性的碱性藻酸盐，碱土金藻酸盐，多元醇和天然的，合成的或半合成的聚合物及其制备方法。 这些高度水合的自支撑膜形式的多糖基质凝胶适合用作皮肤损伤和/或病变的覆盖和保护材料，因为它们可以以所需厚度的自支撑形式获得，是透明的，柔性的，具有 良好的机械特性，适应于病变表面而不强烈粘附在其上，并且可渗透气体，但不渗透液体和细菌; 一种或多种药理活性物质也可以掺入凝胶中。
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公开(公告)号：US5519007A
公开(公告)日：1996-05-21
申请号：US916257
申请日：1992-07-21
IPC分类号： A61K31/16 , A61K31/275 , A61K31/685 , A61K31/70 , A61K31/7028 , A61P25/00 , A61P25/28 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/04 , C07H15/10 , C07H11/00 , C07F9/02
CPC分类号： C07H15/04 , C07C215/24 , C07C233/18 , C07C233/20 , C07C235/08 , C07C237/22 , C07C255/19 , C07C323/58 , C07F9/10 , C07H15/10
摘要： Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: ##STR1## in which --A-- stands for the group --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, n.sub.1 is a whole number of between 6 and 18, n.sub.2 is a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.
摘要翻译： 不含唾液酸的新型衍生物是具有以下两种分子之一的N-酰基脂溶性脂质：其中-A-代表基团-CH = CH-或-CH 2 - CH 2 - ，n1为6〜18的整数，n2为11〜15的整数，X为氢原子或者单糖或二糖或磷酰胆碱的残基，R为衍生自 具有2至24个碳原子的饱和或不饱和脂族羧酸被一个或多个极性基团取代。 本发明的溶血鞘脂衍生物对蛋白激酶C活化具有抑制作用，因此可用于神经系统各种病理学的治疗。
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公开(公告)号：US5416205A
公开(公告)日：1995-05-16
申请号：US155562
申请日：1993-11-22
IPC分类号： A61K8/73 , A61K9/00 , A61K47/36 , A61K47/48 , A61L17/10 , A61L27/20 , A61Q19/00 , A61K9/70 , A61K31/215 , A61K31/725
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S128/912 , Y10S514/912 , Y10S623/924
摘要： Partial esters of alginic acid and salts thereof possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.
摘要翻译： 海藻酸及其盐的部分酯具有重要的生物塑料和药物特性，可用于医疗，外科，化妆品和食品等各个领域。
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