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    Tangential flow perfusion system
    31.
    发明授权
    Tangential flow perfusion system 有权

    公开(公告)号：US09663753B2

    公开(公告)日：2017-05-30

    申请号：US14430346

    申请日：2013-09-25

    Applicant: GE Healthcare Bio-Sciences AB

    Inventor： Klaus Gebauer

    IPC: C12M1/00 ,  C12N1/00 ,  C12M1/34 ,  B01D61/22 ,  B01D63/02 ,  B01D65/02 ,  B01D61/18 ,  B01D63/08

    CPC classification number: C12M29/10 ,  B01D61/18 ,  B01D61/22 ,  B01D63/02 ,  B01D63/08 ,  B01D65/02 ,  B01D2313/243 ,  B01D2313/44 ,  B01D2321/04 ,  C12M29/00 ,  C12M29/02 ,  C12M29/04 ,  C12M29/12 ,  C12M29/16 ,  C12M29/18 ,  C12M41/00 ,  C12M41/40 ,  C12M47/10

    Abstract: The invention discloses a system for perfusion culture of cells which comprises: a bioreactor; a filter unit with a retentate inlet end, a retentate outlet end and a permeate outlet port; a reciprocating pump fluidically connected to the retentate inlet end, with the retentate inlet end fluidically connected to the bioreactor via an inlet check valve arranged to allow flow in the direction from the bioreactor to the retentate inlet end and to block flow in the reverse direction, and where the retentate outlet end is fluidically connected to the bioreactor via an outlet check valve arranged to allow flow in the direction from the retentate outlet end to the bioreactor and to block flow in the reverse direction; and where the inlet and outlet check valves are each fluidically connected to a tubing branch point, which is further connected to the bioreactor via a length of tubing. In an alternative embodiment, each of said inlet and outlet check valves is fluidically connected to the bioreactor via separate lengths of tubing. The invention further discloses a pre-sterilized system for perfusion culture of cells which comprises: a bioreactor; a reciprocating pump and a filter unit fluidically connected to the reciprocating pump and fluidically connected to the bioreactor via at least one aseptic connector.

    Chromatography columns, systems and methods
    32.
    发明授权
    Chromatography columns, systems and methods 有权
    色谱柱，系统和方法

    公开(公告)号：US09527009B2

    公开(公告)日：2016-12-27

    申请号：US14252874

    申请日：2014-04-15

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer

    IPC: G01N30/60 ,  G01N30/38 ,  B01D15/22 ,  B01D15/18 ,  B01D15/26

    CPC classification number: G01N30/6004 ,  B01D15/18 ,  B01D15/22 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6052 ,  G01N30/606

    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

    Abstract translation: 本发明涉及轴流色谱柱，通过使用这种色谱柱分离液体中的一种或多种分析物的方法，以及采用这种色谱柱的系统。 该柱包括第一端口和第二端口，第一端口和第二端口在色谱柱上的床空间的水平以上基本相同的水平或高度。

    Chromatography column distribution system
    39.
    发明授权
    Chromatography column distribution system 有权
    色谱柱分配系统

    公开(公告)号：US09279789B2

    公开(公告)日：2016-03-08

    申请号：US14625497

    申请日：2015-02-18

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer

    IPC: G01N30/60 ,  B01D15/14

    CPC classification number: B01D15/14 ,  G01N30/6017 ,  Y10T137/6851

    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position. The length of the portions correspond to at least 80% of the distance between the first and outer radial position and the outer radial position.

    Abstract translation: 色谱柱分配系统包括一组第一床支撑肋，其从靠近板的中心的内部第一径向位置径向延伸到更接近板周边的外径向位置，以及至少一组中间床支撑肋 从中间径向位置开始并延伸到靠近板周边的外径向位置。 在相邻的床支撑肋之间形成通道。 期望的局部有效通道高度根据从第一径向位置到外径向位置的预定公式而变化。 肋或通道的横截面积适于使得实际的局部有效通道高度在位于第一径向位置和外径向位置之间的分配系统的部分之上的所需局部有效通道高度的15％以内 。 部分的长度对应于第一和外径向位置与外径向位置之间的距离的至少80％。

    Tangential Flow Perfusion System
    40.
    发明申请
    Tangential Flow Perfusion System 有权
    切向流灌注系统

    公开(公告)号：US20150247114A1

    公开(公告)日：2015-09-03

    申请号：US14430346

    申请日：2013-09-25

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： Klaus Gebauer

    IPC: C12M1/00 ,  C12M1/34 ,  B01D65/02 ,  B01D63/02 ,  B01D61/22

    CPC classification number: C12M29/10 ,  B01D61/18 ,  B01D61/22 ,  B01D63/02 ,  B01D63/08 ,  B01D65/02 ,  B01D2313/243 ,  B01D2313/44 ,  B01D2321/04 ,  C12M29/00 ,  C12M29/02 ,  C12M29/04 ,  C12M29/12 ,  C12M29/16 ,  C12M29/18 ,  C12M41/00 ,  C12M41/40 ,  C12M47/10

    Abstract: The invention discloses a system for perfusion culture of cells which comprises: a bioreactor; a filter unit with a retentate inlet end, a retentate outlet end and a permeate outlet port; a reciprocating pump fluidically connected to the retentate inlet end, with the retentate inlet end fluidically connected to the bioreactor via an inlet check valve arranged to allow flow in the direction from the bioreactor to the retentate inlet end and to block flow in the reverse direction, and where the retentate outlet end is fluidically connected to the bioreactor via an outlet check valve arranged to allow flow in the direction from the retentate outlet end to the bioreactor and to block flow in the reverse direction; and where the inlet and outlet check valves are each fluidically connected to a tubing branch point, which is further connected to the bioreactor via a length of tubing. In an alternative embodiment, each of said inlet and outlet check valves is fluidically connected to the bioreactor via separate lengths of tubing. The invention further discloses a pre-sterilized system for perfusion culture of cells which comprises: a bioreactor; a reciprocating pump and a filter unit fluidically connected to the reciprocating pump and fluidically connected to the bioreactor via at least one aseptic connector.

    Abstract translation: 本发明公开了一种细胞灌注培养系统，包括：生物反应器; 具有滞留物入口端的过滤单元，滞留物出口端和渗透物出口; 流体连接到滞留物入口端的往复泵，其中滞留物入口端通过入口止回阀流体连接到生物反应器，入口止回阀允许沿从生物反应器到滞留物入口端的方向流动并阻止反向流动， 并且其中所述滞留物出口端经由出口止回阀流体连接到所述生物反应器，所述出口止回阀被布置成允许沿从所述滞留物出口端到所述生物反应器的方向流动并阻止在相反方向流动; 并且其中入口和出口止回阀各自流体地连接到管道分支点，管道分支点通过一段管道进一步连接到生物反应器。 在替代实施例中，所述入口和出口止回阀中的每一个通过分开的管道流体地连接到生物反应器。 本发明还公开了一种用于细胞灌注培养的预灭菌系统，其包括：生物反应器; 往复泵和过滤器单元，其流体连接到往复泵，并经由至少一个无菌连接器流体连接到生物反应器。

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