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49 条记录 (耗时 0.039 秒)

    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
    34.
    发明申请
    Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same 失效
    含有荧光物质或造影剂的胶乳聚合物颗粒及其制备方法

    公开(公告)号：US20060138381A1

    公开(公告)日：2006-06-29

    申请号：US10539746

    申请日：2003-12-19

    申请人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    发明人： Naoya Shibata ,  Yukio Nagasaki ,  Kazunori Kataoka

    IPC分类号： H01F1/26

    CPC分类号： C08F290/06 ,  A61K49/0414 ,  C08F2/44 ,  C08F290/00 ,  C08F290/02 ,  C08F290/062

    摘要： This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.

    摘要翻译： 本发明提供了一种将无机荧光物质或无机造影剂有效地并入用于诊断试验等的胶乳聚合物颗粒中的方法，并且还提供了由此产生的荧光物质的胶乳聚合物颗粒，其表现出降低的非特异性吸附蛋白质 或类似物。 所述胶乳聚合物颗粒通过制备胶乳形成单体，至少具有亲水性聚合物链段的大分子单体和无机荧光物质或无机造影剂同时存在于水性介质中并使其进行聚合反应而制备。

    Polyethylene glycol-modified semiconductor nanoparticles, method for producing the same, and material for biological diagnosis
    35.
    发明授权
    Polyethylene glycol-modified semiconductor nanoparticles, method for producing the same, and material for biological diagnosis 有权
    聚乙二醇改性半导体纳米粒子，其制造方法以及生物诊断用材料

    公开(公告)号：US07041371B2

    公开(公告)日：2006-05-09

    申请号：US10810305

    申请日：2004-03-26

    申请人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

    发明人： Atsuhiko Ogura ,  Eui-chul Kang ,  Kazunori Kataoka ,  Yukio Nagasaki

    IPC分类号： B32B5/16

    CPC分类号： C30B7/14 ,  C30B7/00 ,  C30B29/48 ,  C30B29/605 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： This invention provides PEG-modified semiconductor nanoparticles of which fluorescence intensity is effectively inhibited from lowering, which are capable of forming a stable dispersion in water, and which are capable of bonding easily with biomolecules having specific recognition, as well as methods for conveniently preparing such nanoparticles, and a material for biological diagnosis. The water-soluble PEG-modified semiconductor nanoparticles of the present invention includes a structure having PEG of a number average molecular weight of 300 to 20000 having a thiol group at one end, bonded via cadmium to II–VI semiconductor nanocrystals of a core-shell structure having a ZnX (wherein X stands for O, S, Se, or Te) shell.

    摘要翻译： 本发明提供了PEG修饰的半导体纳米粒子，其荧光强度被有效地抑制，能够在水中形成稳定的分散体，并且能够容易地与具有特定识别性的生物分子结合，以及方便地制备 纳米颗粒和用于生物诊断的材料。 本发明的水溶性PEG改性的半导体纳米粒子包括数均分子量为300〜20000的具有一端具有硫醇基的PEG的结构，其通过镉键合到芯壳的II-VI半导体纳米晶体 具有ZnX（其中X代表O，S，Se或Te）壳的结构。

    Antitumor agents comprising as the principal compounds containing silicon and nitrogen
    37.
    发明授权
    Antitumor agents comprising as the principal compounds containing silicon and nitrogen 失效
    包含含有硅和氮的主要化合物的抗肿瘤剂

    公开(公告)号：US06274561B1

    公开(公告)日：2001-08-14

    申请号：US09224361

    申请日：1999-01-04

    申请人： Masao Kato ,  Kazunori Kataoka ,  Yukio Nagasaki ,  Tsutomu Takezawa

    发明人： Masao Kato ,  Kazunori Kataoka ,  Yukio Nagasaki ,  Tsutomu Takezawa

    IPC分类号： A61K3170

    CPC分类号： A61K31/704 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

    摘要： Antitumor agent which comprises as the principal agent a mixture of organic compounds having amino group and silyl group (reffered to as silamines) and represented by structural formulae with Adriamycin. Use of silamines in the form of a mixture with Adriamycin, which is an anti-cancer agent showing a potent effect but having extremely serious side effects, makes it possible to highly potentiate the anti-cancer properties of Adriamycin. As a result, the dose of Adriamycincan be reduced and thus its side effects can be relatively relieved as compared with the case where it is used alone. [wherein R1, R2, R3, R4, R5, R6, R7 and R8 represent each hydrogen or C1-10 alkyl, aryl or aralkyl, or the pair of R1 with R2 and that of R5 with R6 may be bonded via alkylene, allylene or aralkylene.]

    摘要翻译： 抗肿瘤剂包括具有氨基和甲硅烷基的有机化合物（被称为硅烷胺）并由结构式与阿霉素表示的混合物作为主剂。 以与阿霉素形成混合物形式的硅烷胺的使用，其是显示出有效作用但具有非常严重的副作用的抗癌剂，使得可以高度增强阿霉素的抗癌特性。 结果，与其单独使用的情况相比，阿立霉素的剂量减少，因此其副作用相对缓解[其中R1，R2，R3，R4，R5，R6，R7和R8表示每个氢 或C 1-10烷基，芳基或芳烷基，或R 1与R 2和R 5与R 6的一对可以通过亚烷基，亚烯丙基或亚芳烷基键合。

    Polyethylene oxides having saccharide residue at one end and different functional group at another end
    38.
    发明授权
    Polyethylene oxides having saccharide residue at one end and different functional group at another end 失效
    一端具有糖残基和另一端具有不同官能团的聚氧化乙烯

    公开(公告)号：US5973069A

    公开(公告)日：1999-10-26

    申请号：US930855

    申请日：1997-12-18

    申请人： Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

    发明人： Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

    IPC分类号： C08G65/32 ,  A61K47/48 ,  C08G63/664 ,  C08G65/26 ,  C08G65/329 ,  C08L71/02 ,  C08G65/08

    CPC分类号： A61K47/48215 ,  A61K47/488 ,  C08G63/664 ,  C08G65/2606 ,  C08G65/329 ,  C08L71/02 ,  Y10T428/2984 ,  Y10T428/2985

    摘要： This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH--, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.

    摘要翻译： PCT No.PCT / JP96 / 01020 Sec。 371 1997年12月18日第 102（e）日期1997年12月18日PCT提交1996年4月12日PCT公布。 公开号WO96 / 32434 日本特开1996年10月17日本发明提供由下式表示的异炔属低聚物或聚合物：其中A表示糖残基，L表示由下式表示的连接基团，其中R 1和R 2独立地表示低级烷基，芳烷基或芳基 X表示单键或-CH 2 CH-，Z表示形成不饱和酯或醚的基团，或与-CH 2 CH 2 - 结合的卤素等官能团，n表示5-10,000的整数，m表示整数 为0或2-10,000。 本发明还提供了使用在其末端具有糖残基的聚环氧乙烷 - 聚酯嵌段聚合物制备上述低聚物或聚合物以及进一步的高分子量胶束的方法。 预期所述低聚物或聚合物表现出优异的生物利用度，并且还预期在现场使用，例如用于药物递送或诊断试剂的载体。