摘要:
A compound represented by formula (I) (wherein all the symbols are as defined in the specification) or a salt thereof Since the compound represented by formula (I) or a salt thereof has a regulatory activity for peroxisome proliferator activated receptor, the compound represented by formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or therapeutic agent for diseases associating metabolic disorders (e.g., diabetes, adiposity, metabolic syndrome, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipidemia, atherosclerosis, hypertension, circulatory diseases, overeating, ischemic heart diseases, etc., a HDL cholesterol-elevating agent, a LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or metabolic syndrome.
摘要:
An image display system has an image display apparatus and a peripheral device that can be mounted on the image display apparatus. The image display apparatus includes a first electrode for electrically connecting the image display apparatus and peripheral device, and the peripheral device includes a second electrode for electrically connecting the image display apparatus and peripheral device. These electrodes are placed so as to have contact with one another when the peripheral device is mounted on the image display apparatus. In addition, the image display system moves the mounting position of the peripheral device on the image display apparatus as appropriate. The system minimizes cables used for electrical connections between the image display apparatus and peripheral devices, makes the apparatus compact and allows adoption of a variety of layouts.
摘要:
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.
摘要:
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.
摘要:
A panel support structure for supporting a flat display panel capable of reducing the weight of the panel support structure while a sufficient structural strength is maintained and capable of preventing the display performance of the flat display panel from being lowered by a change in an ambient temperature. A flat display panel is fixedly supported by an X-character shaped supporting member via dampers fitted in the four corners of the flat display panel by the flat panel fixing parts of the supporting member. The supporting member is disposed along diagonal lines extending between the four corners of the flat display panel and has a rectangular cross section whose longer side is directed in the thickness direction of the flat display panel.
摘要:
A liquid crystal apparatus is constituted by a display device for data display, a drive circuit unit for driving the display device, a unit substrate for supplying electric signals to the drive circuit unit, and a tape-form film carrier comprising an insulating substrate and a conductor covered with the insulating substrate for connecting the display device, the drive circuit unit and the unit substrate. A part of the film carrier is provided with a blank portion where the insulating substrate is locally removed to absorb a stress applied to the film carrier. A unit substrate constituting the drive circuit unit is screwed to a supporting member so as to allow a movement thereof relative to the supporting member by use of a space regulating means surrounding the screw shank.
摘要:
A liquid crystal display apparatus is constituted by: a housing; a liquid crystal panel comprising a liquid crystal disposed between a pair of substrates each provided with electrodes, the liquid crystal panel being affixed to the housing; and a backlight for illuminating the liquid crystal panel, detachably affixed to the housing. A light-transmissive plate, such as a diffusion plate, allowing transmission of light from the backlight is further disposed between the liquid crystal panel and the backlight so as to define an almost closed first space in cooperation with the liquid crystal panel, whereby the first space retaina its almost closed state even when the backlight is detached from the housing.
摘要:
The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector comprising the DNA; host cells transformed with the vector; antibody against the polypeptide; pharmaceutical compositions containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and screening methods for the prevention and/or treatment agent.Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improves the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要:
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from, risk factors of diabetes or syndrome X.
摘要:
The present invention relates to the compound represented by formula (I) (wherein R1 and R2 is hydrogen atom, C1-8 alkyl etc.; R3 is C1-8 alkyl which may be substituted with 1 to 3 halogen atom(s), phenyl; R4 is hydrogen atom etc.; R5 and R6 is hydrogen atom, C1-8 alkyl etc.; X is sulfur atom or oxygen atom etc.; ringA is cyclic group which may have a substituent(s).), or a salt thereof. Toxicity of the compound represented by formula (I) is very low, and it is safe enough to use as a pharmaceutical agent and since it has PPAR δ agonistic activity, it is useful as preventive and/or therapeutic agent for glucose.lipid metabolic disorder, hypertension, circulatory diseases etc.
摘要翻译:本发明涉及由式(I)表示的化合物(其中R 1和R 2是氢原子,C 1-8烷基等; R 3 可以被1至3个卤素原子取代的C 1-8烷基,苯基; R 4是氢原子等; R 5和 R 6是氢原子,C 1-8烷基等; X是硫原子或氧原子等;环A是可以具有取代基的环状基团)或其盐。 由式(I)表示的化合物的毒性非常低,并且作为药物使用是安全的,并且由于其具有PPARδ激动活性,因此它可用作葡萄糖脂代谢紊乱的预防和/或治疗剂 ,高血压,循环系统疾病等