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    DNA sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
    33.
    发明授权
    DNA sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to DNA 有权
    使用具有不同有机涂层的多个金属层结构形成与DNA不同的瞬时键合的DNA测序

    公开(公告)号：US09285339B2

    公开(公告)日：2016-03-15

    申请号：US14624868

    申请日：2015-02-18

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Philip S. Waggoner

    IPC: G01N27/447 ,  B82Y30/00 ,  B82Y15/00 ,  G01N33/487 ,  C12Q1/68

    CPC classification number: G01N33/48721 ,  B82Y15/00 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N27/44791 ,  Y10S977/924 ,  C12Q2563/157

    Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

    Abstract translation: 纳米器件包括填充有导电流体的储存器和分离储存器的膜。 通过具有由绝缘层分隔的电极层的膜形成纳米孔。 某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。 第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。 当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为要测量的第一和第二瞬态键作为用于区分基底的当前签名行进。 运动控制瞬态键比第一和第二瞬态键强。

    Integrated carbon nanotube field effect transistor and nanochannel for sequencing
    36.
    发明授权
    Integrated carbon nanotube field effect transistor and nanochannel for sequencing 有权
    集成碳纳米管场效应晶体管和纳米通道进行测序

    公开(公告)号：US08963215B2

    公开(公告)日：2015-02-24

    申请号：US13690963

    申请日：2012-11-30

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: G01N27/403 ,  G01N27/414 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/487

    CPC classification number: G01N27/4146 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/48721 ,  Y10S977/958

    Abstract: A mechanism is provided for base recognition of an integrated transistor and nanochannel. A target molecule is forced down to a carbon nanotube a single base at a time in the nanochannel by applying a gate voltage to a top electrode, and/or a narrow thickness of the nanochannel. The nanochannel exposes an exposed portion of the carbon nanotube at a bottom wall, and the top electrode is positioned over the exposed portion. The exposed portion of the carbon nanotube is smaller than the distance between bases to only accommodate the single base at a time. The target molecule is stretched by the narrow thickness and by applying a traverse voltage across a length direction of the nanochannel. The target molecule is frictionally restricted by the narrow thickness of the nanochannel to stretch is restrictedly translocates in the length direction. Current is measured to determine an identity of the single base.

    Abstract translation: 提供了用于集成晶体管和纳米通道的基础识别的机制。 通过向顶部电极施加栅极电压和/或纳米通道的窄厚度，靶分子在纳米通道中一次被强制下降到单个碱基。 纳米通道暴露在底壁处的碳纳米管的暴露部分，并且顶部电极位于暴露部分上方。 碳纳米管的暴露部分小于基底之间的距离，以便一次仅容纳单个基底。 靶分子通过窄的厚度被拉伸并且通过在纳米通道的长度方向施加横动电压。 目标分子被纳米通道的窄厚度摩擦地限制，以在长度方向上被限制性地转位。 测量电流以确定单个碱基的身份。

    INTEGRATED CARBON NANOTUBE FIELD EFFECT TRANSISTOR AND NANOCHANNEL FOR SEQUENCING
    37.
    发明申请
    INTEGRATED CARBON NANOTUBE FIELD EFFECT TRANSISTOR AND NANOCHANNEL FOR SEQUENCING 有权
    集成碳纳米管场效应晶体管和用于测序的纳米通道

    公开(公告)号：US20140152291A1

    公开(公告)日：2014-06-05

    申请号：US13690963

    申请日：2012-11-30

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

    Inventor： Ali Afzali-Ardakani ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: G01N27/414

    CPC classification number: G01N27/4146 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/02 ,  G01N33/48721 ,  Y10S977/958

    Abstract: A mechanism is provided for base recognition of an integrated transistor and nanochannel. A target molecule is forced down to a carbon nanotube a single base at a time in the nanochannel by applying a gate voltage to a top electrode, and/or a narrow thickness of the nanochannel. The nanochannel exposes an exposed portion of the carbon nanotube at a bottom wall, and the top electrode is positioned over the exposed portion. The exposed portion of the carbon nanotube is smaller than the distance between bases to only accommodate the single base at a time. The target molecule is stretched by the narrow thickness and by applying a traverse voltage across a length direction of the nanochannel. The target molecule is frictionally restricted by the narrow thickness of the nanochannel to stretch is restrictedly translocates in the length direction. Current is measured to determine an identity of the single base.

    Abstract translation: 提供了用于集成晶体管和纳米通道的基础识别的机制。 通过向顶部电极施加栅极电压和/或纳米通道的窄厚度，靶分子在纳米通道中一次被强制下降到单个碱基。 纳米通道暴露在底壁处的碳纳米管的暴露部分，并且顶部电极位于暴露部分上方。 碳纳米管的暴露部分小于基底之间的距离，以便一次仅容纳单个基底。 靶分子通过窄的厚度被拉伸并且通过在纳米通道的长度方向施加横动电压。 目标分子被纳米通道的窄厚度摩擦地限制，以在长度方向上被限制性地转位。 测量电流以确定单个碱基的身份。

    Increasing the capture zone by nanostructure patterns
    40.
    发明授权
    Increasing the capture zone by nanostructure patterns 有权

    公开(公告)号：US10094805B2

    公开(公告)日：2018-10-09

    申请号：US15583501

    申请日：2017-05-01

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC: G01N1/10 ,  G01N27/447 ,  G01N33/487 ,  C12Q1/6869

    Abstract: Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

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