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公开(公告)号：US20150361463A1
公开(公告)日：2015-12-17
申请号：US14740749
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/40 , C12P7/24 , C07C69/533 , C12N9/16 , C12N9/10 , C12N9/02 , C12N9/18 , C12P7/44 , C12P11/00
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
摘要翻译： 该文献描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，辅酶A转移酶和辅酶A连接酶从前体如2-氧戊二酸生产2,3-脱氢阿迪普基-CoA甲酯的生化途径，以及 表达一种或多种此类酶的重组宿主。 可以使用反式-2-烯酰辅酶A还原酶将2,3-脱氢脱苄基-CoA甲酯酶促转化为己二酰CoA，甲酯酶又可以酶促转化为己二酸，6-氨基己酸6-羟基己酸酯 ，己内酰胺，六亚甲基二胺或1,6-己二醇。
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32.发明授权Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage 有权通过与碳储存相关的CoA依赖性碳链延长生产6碳化学品的方法公开(公告)号：US09102960B2
公开(公告)日：2015-08-11
申请号：US14106124
申请日：2013-12-13
CPC分类号： C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
摘要： This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogs enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
摘要翻译： 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延伸酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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33.发明申请Methods Of Producing 6-Carbon Chemicals Via Methyl-Ester Shielded Carbon Chain Elongation 有权通过甲基酯屏蔽碳链延伸生产6碳化合物的方法公开(公告)号：US20140199737A1
公开(公告)日：2014-07-17
申请号：US14139225
申请日：2013-12-23
CPC分类号： C12P13/005 , C12N9/1096 , C12N9/16 , C12N9/86 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/02 , C12Y206/01 , C12Y301/02
摘要： This document describes biochemical pathways for producing adipic acid, 6-aminohexanoic acid, 6-hydroxhexanoic acid, hexamethylenediamine, caprolactam, or 1,6-hexanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
摘要翻译： 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团来生产己二酸，6-氨基己酸，6-羟基己酸，六亚甲基二胺，己内酰胺或1,6-己二醇的生化途径 C6脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于接受甲酯屏蔽二羧酸底物的酶或同系物。
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34.发明申请Methods Of Producing 7-Carbon Chemicals Via Pyruvate And Succinate Semialdehyde Aldol Condensation 有权通过丙酮酸和琥珀酸生产七碳化合物半醛醛缩醇的方法公开(公告)号：US20140193864A1
公开(公告)日：2014-07-10
申请号：US14138992
申请日：2013-12-23
CPC分类号： C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
摘要： This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
摘要翻译： 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团，生成一种或多种庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇的生化途径 由琥珀酸半醛或丙酮酸生成的C7脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于琥珀酸半醛和丙酮酸的醛醇缩合。
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公开(公告)号：US10174330B2
公开(公告)日：2019-01-08
申请号：US14666085
申请日：2015-03-23
IPC分类号： C12N15/81 , C12P13/00 , C12P7/18 , C12P7/44 , C12P7/42 , C12P17/10 , C12N15/52 , C12N9/00 , C12N9/16 , C12N9/80 , C12N9/86 , C12N9/02 , C12N9/10
摘要： This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6; backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
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公开(公告)号：US09920339B2
公开(公告)日：2018-03-20
申请号：US14741392
申请日：2015-06-16
发明人： Nadia Fatma Kadi , Mariusz Kamionka , Alexander Brett Foster , Alex Van Eck Conradie , Adriana Leonora Botes
IPC分类号： C12P7/62 , C12P7/40 , C12P7/42 , C12P7/44 , C12N1/20 , C12N1/00 , C07H21/04 , C12P13/00 , C07C229/08 , C12N9/10 , C07C69/42 , C12N9/02 , C12N9/18 , C12N9/16 , C12N15/52
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].
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37.发明申请公开(公告)号：US20170369914A1
公开(公告)日：2017-12-28
申请号：US15643426
申请日：2017-07-06
CPC分类号： C12P13/001 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/88 , C12N15/52 , C12P7/42 , C12P13/005 , C12P13/04 , C12Y102/99006 , C12Y103/01031 , C12Y402/01 , C12Y403/01
摘要： This document describes biochemical pathways for producing 2-aminopimelate from 2,6-diaminopimelate, and methods for converting 2-aminopimelate to one or more of adipic acid, adipate semialdehyde, caprolactam, 6-aminohexanoic acid, 6-hexanoic acid, hexamethylenediamine, or 1,6-hexanediol by decarboxylating 2-aminopimelate into a six carbon chain aliphatic backbone and enzymatically forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in the backbone.
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38.发明申请公开(公告)号：US20170369907A1
公开(公告)日：2017-12-28
申请号：US15638225
申请日：2017-06-29
CPC分类号： C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
摘要： This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
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公开(公告)号：US09777295B2
公开(公告)日：2017-10-03
申请号：US14092115
申请日：2013-11-27
CPC分类号： C12P5/026 , Y02E50/343
摘要： The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-CoA dehydratase, a 2-hydroxyacyl-CoA dehydratase, an isovaleryl-CoA/acyl-CoA dehydrogenase and a mevalonate diphosphate decarboxylase, or using recombinant host cells expressing one or more such enzymes.
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公开(公告)号：US20150361464A1
公开(公告)日：2015-12-17
申请号：US14740933
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/44 , C12P7/42 , C12N9/10 , C12N9/88 , C12N9/06 , C12N9/80 , C12N9/02 , C07C229/08 , C12P7/18
CPC分类号： C12N9/0008 , C07C229/08 , C12N9/0022 , C12N9/0069 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/18 , C12P7/42 , C12P7/46 , C12P13/005 , C12Y102/01003 , C12Y102/01004 , C12Y104/03021 , C12Y113/12002 , C12Y206/01 , C12Y305/0103 , C12Y401/01
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as cadaverine or 5-aminopentanamide.
摘要翻译： 该文献描述了通过在C5主链基质中形成一个或两个由羧基，胺或羟基组成的末端官能团来生产戊二酸，5-氨基戊酸，5-羟基戊酸或1,5-戊二醇的生化途径，例如 尸胺或5-氨基戊酰胺。
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