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公开(公告)号：US09617572B2
公开(公告)日：2017-04-11
申请号：US14138827
申请日：2013-12-23
CPC分类号： C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
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2.发明授权Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis 有权通过与辅酶B合成相关的c1碳链延长生产7-碳化学物质的方法公开(公告)号：US09580731B2
公开(公告)日：2017-02-28
申请号：US14138971
申请日：2013-12-23
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
摘要翻译： 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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公开(公告)号：US09422580B2
公开(公告)日：2016-08-23
申请号：US13916156
申请日：2013-06-12
CPC分类号： C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
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4.发明授权公开(公告)号：US10196657B2
公开(公告)日：2019-02-05
申请号：US14139072
申请日：2013-12-23
IPC分类号： C12P13/00 , C12P7/18 , C12N1/20 , C12N15/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/88 , C07H21/04 , C12P7/44 , C12P7/42 , C12N15/52
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
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5.发明授权公开(公告)号：US09920336B2
公开(公告)日：2018-03-20
申请号：US14139142
申请日：2013-12-23
IPC分类号： C12P37/02 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/16 , C12N9/10 , C12N15/00 , C07H21/04 , C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/00
CPC分类号： C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
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6.发明申请Methods Of Producing 7-Carbon Chemicals Via Methyl-Ester Shielded Carbon Chain Elongation 审中-公开通过甲基酯屏蔽碳链延伸生产7碳化合物的方法公开(公告)号：US20140186904A1
公开(公告)日：2014-07-03
申请号：US14139072
申请日：2013-12-23
CPC分类号： C12P13/001 , C12N9/0006 , C12N9/001 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
摘要翻译： 该文献描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团来生产庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径。 本文描述的这些途径，代谢工程和培养策略依赖于接受甲酯屏蔽二羧酸底物的酶或同系物。
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公开(公告)号：US09637764B2
公开(公告)日：2017-05-02
申请号：US14138904
申请日：2013-12-23
CPC分类号： C12P13/001 , C12N9/0008 , C12N9/1096 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/002 , C12Y102/99006 , C12Y301/02002
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
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8.发明申请Methods Of Producing 7-Carbon Chemicals Via Pyruvate And Succinate Semialdehyde Aldol Condensation 有权通过丙酮酸和琥珀酸生产七碳化合物半醛醛缩醇的方法公开(公告)号：US20140193864A1
公开(公告)日：2014-07-10
申请号：US14138992
申请日：2013-12-23
CPC分类号： C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
摘要： This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
摘要翻译： 本文件描述了通过在羧基，胺或羟基中形成一个或两个末端官能团，生成一种或多种庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇的生化途径 由琥珀酸半醛或丙酮酸生成的C7脂肪族主链基质。 本文描述的这些途径，代谢工程和培养策略依赖于琥珀酸半醛和丙酮酸的醛醇缩合。
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9.发明申请公开(公告)号：US20170369907A1
公开(公告)日：2017-12-28
申请号：US15638225
申请日：2017-06-29
CPC分类号： C12P7/40 , C12N9/0006 , C12N15/52 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/002
摘要： This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
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