公开(公告)号：US20100145415A1

公开(公告)日：2010-06-10

申请号：US12445061

申请日：2007-10-11

申请人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

发明人： Jonathan S. Dahm ,  William Louis Barnard ,  James C. Chen ,  David B. Shine

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B18/24 ,  A61N5/0601 ,  A61N2005/0652

摘要： A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.

摘要翻译： 向患者提供光治疗的光递送系统包括具有多个光源的导管组件，所述多个光源向患者内的目标部位透射光。 在一个实施例中，光输送系统具有安装到柔性透明基底的多个光源，其至少部分延伸穿过导管组件的远端。 光源可以引线键合或以倒装芯片布置安装在基座上。 在产生远端的一个实施例中，光能源阵列可以由固定装置的支架阵列保持。 施加真空以将每个光能源固定在相应的支架中。 当施加真空时，能量源通过引线接合电连接。 可以减少或停止真空，从而允许从固定装置移除光能源。

公开(公告)号：US20100035321A1

公开(公告)日：2010-02-11

申请号：US12104172

申请日：2008-04-16

申请人： Brian D. Wilkerson ,  James A. Burns, JR. ,  James C. Chen

发明人： Brian D. Wilkerson ,  James A. Burns, JR. ,  James C. Chen

IPC分类号： C12N13/00 ,  C12M1/00 ,  C12N1/12

CPC分类号： C12N5/04 ,  C12M21/02 ,  C12M31/10 ,  C12M33/00 ,  C12N13/00 ,  C12P1/00 ,  C12P7/6409 ,  C12P7/6463

摘要： Systems, devices, and methods for releasing one or more cell components from a photosynthetic organism. A bioreactor system is operable for growing photosynthetic organisms. Some of the methods include contacting the photosynthetic organism with an energy-activatable sensitizer, and activating the energy-activatable sensitizer, thereby releasing a cellular component from at least one of, for example, a membrane structure, tubule, vesicle, cisterna, organelle, cell compartment, plastid, or mitochondrion, associated with the photosynthetic organisms.

摘要翻译： 用于从光合生物释放一种或多种细胞组分的系统，装置和方法。 生物反应器系统可用于生长光合生物。 一些方法包括使光合生物与能量激活的敏化剂接触，并激活能量可激活的敏化剂，从而从例如膜结构，小管，囊泡，细胞器，细胞器，细胞器中的至少一种释放细胞组分， 与光合生物相关的细胞室，质体或线粒体。

公开(公告)号：US20080269846A1

公开(公告)日：2008-10-30

申请号：US12101069

申请日：2008-04-10

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer K. Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean M. Bishop ,  Nick Yeo ,  Hugh Narciso ,  James C. Chen ,  William L. Barnard ,  Alexei Naimushin

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer K. Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean M. Bishop ,  Nick Yeo ,  Hugh Narciso ,  James C. Chen ,  William L. Barnard ,  Alexei Naimushin

IPC分类号： A61N5/06 ,  A61B17/00

CPC分类号： A61N5/0601 ,  A61B2017/22051 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652

摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.

摘要翻译： 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。 另一种装置是具有两个气囊的导管和在其间延伸的套管。 在套管内，导管包括光源和扩张构件。

公开(公告)号：US07200659B2

公开(公告)日：2007-04-03

申请号：US11031848

申请日：2005-01-07

申请人： Mark S. Bayus ,  James C. Chen ,  Steven E. Klein ,  Richard A. Ripberger

发明人： Mark S. Bayus ,  James C. Chen ,  Steven E. Klein ,  Richard A. Ripberger

IPC分类号： G06F15/173

CPC分类号： G06F3/0637 ,  G06F3/0622 ,  G06F3/0689

摘要： A log-in resource release system includes a set of lists for managing log-in requests to a processing cluster input/output port from host server input/output ports. Host servers that have been granted memory structures within a memory storage device (“configured hosts”) are granted priority access to a storage processing device's input/output port (“cluster port”). If the cluster port has exhausted its log-in resources, log-on requests from non-configured hosts will be not be accepted. New log-in requests from configured hosts will cause a host connected at a link or transport layer but not an upper layer to be logged off. If no hosts are connected only at the link or transport layer, a non-configured host connected at an upper layer will be logged off. If only configured hosts are connected and only at the upper layer, the log-on request by the configured host will be denied.

摘要翻译： 登录资源释放系统包括一组用于管理从主机服务器输入/输出端口到处理集群输入/输出端口的登录请求的列表。 被授予内存存储设备（“配置的主机”）内存结构的主机服务器被授予对存储处理设备的输入/输出端口（“群集端口”）的优先权访问权限。 如果群集端口已耗尽其登录资源，则不会接受未配置主机的登录请求。 配置主机的新登录请求将导致连接在链路或传输层但不是上层的主机被注销。 如果没有主机仅在链路或传输层连接，则在上层连接的未配置的主机将被注销。 如果仅配置的主机已连接，并且仅在上层，则配置的主机的登录请求将被拒绝。

公开(公告)号：US06580228B1

公开(公告)日：2003-06-17

申请号：US09644253

申请日：2000-08-22

申请人： James C. Chen ,  Darrin Huston ,  Brent Wiscombe

发明人： James C. Chen ,  Darrin Huston ,  Brent Wiscombe

IPC分类号： H05B3700

CPC分类号： H01L25/0753 ,  F21K9/232 ,  F21K9/90 ,  F21V3/06 ,  F21V3/061 ,  F21V3/062 ,  F21V23/02 ,  F21Y2107/30 ,  F21Y2115/10 ,  H01L2924/0002 ,  Y10S362/80 ,  H01L2924/00

摘要： A lamp using solid-state light emitting sources is configured to be used in a conventional socket. The lamp includes a flexible substrate on which are mounted a plurality of light emitting sources, such as light emitting diodes (LEDs) in spaced-apart array. In one embodiment, a flexible substrate configured as a generally rectangular panel formed into a cylindrical shape includes a plurality of conductive traces to which the LEDs are connected both mechanically and electrically. The flexible substrate is then enclosed within a light transmissive translucent cover that is attached to a base in which is disposed a power supply. The base is shaped and configured to be threaded into a conventional incandescent light socket and includes a center terminal through which AC line power is supplied to the power supply. The power supply provides an appropriate voltage and current to energize the light sources so that they produce a white light that is emitted radially outward around a longitudinal axis of the lamp. In a different embodiment, the light sources are mounted on a flexible substrate formed as a strand or thread that is wound in a helix around a cylindrical support. The light sources are also provided on a flap that covers the end of the cylinder so that light is emitted through the top or end of the cover. Also included is a solid-state lamp adapted to work in a conventional three-way socket.

摘要翻译： 使用固态发光源的灯被配置为在常规插座中使用。 该灯包括柔性基板，其上安装有多个发光源，例如间隔开阵列的发光二极管（LED）。 在一个实施例中，被配置为形成为圆柱形的大致矩形面板的柔性基板包括多个导电迹线，LED均以机械和电气方式连接到该导电迹线。 然后将柔性基板封闭在透光半透明盖中，透光半透明盖附接到设置有电源的基座。 基座被成形并配置成螺纹连接到常规的白炽灯插座中，并且包括中心端子，通过该中心端子向电源供应AC线路电力。 电源提供适当的电压和电流以激励光源，使得它们产生围绕灯的纵向轴线径向向外发射的白光。 在不同的实施例中，光源安装在形成为绕圆柱形支撑件以螺旋形缠绕的线或线的柔性基底上。 光源还设置在覆盖圆柱体的端部的翼片上，使得光通过盖的顶部或端部发射。 还包括适于在常规三路插座中工作的固态灯。

公开(公告)号：US06416531B2

公开(公告)日：2002-07-09

申请号：US09103761

申请日：1998-06-24

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61B1820

CPC分类号： A61N5/062 ,  A61B2018/2211 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0652

摘要： Light is administered during photodynamic therapy (PDT) for an extended period of time at a plurality of sites distributed within the abnormal tissue of a tumor. A clinical study has shown that a substantially greater volume of abnormal tissue in a tumor is destroyed by the extended administration of light therapy from a plurality of probes than would have been expected based upon the teaching of the prior art. In this process, a plurality of light emitting optical fibers or probes are deployed in a spaced-apart array. After a photoreactive agent is absorbed by the abnormal tissue, the light therapy is administered for at least three hours. The greater volume of necrosis in the tumor is achieved due to one or more concomitant effects, including: the inflammation of damaged abnormal tissue and resultant immunological response of the patient's body; the diffusion and circulation of activated photoreactive agent outside the expected fluence zone, which is believed to destroy the abnormal tissue; a retrograde thrombosis or vascular occlusion outside of the expected fluence zone; and, the collapse of the vascular system that provides oxygenated blood to portions of the tumor outside the expected fluence zone. In addition, is possible that molecular oxygen diffusing and circulating into the expected fluence zone is converted to singlet oxygen during the extended light therapy, causing a gradient of hypoxia and anoxia that destroys the abnormal tissue outside the expected fluence zone.

摘要翻译： 在光动力学治疗（PDT）期间，在分布在肿瘤的异常组织内的多个部位，长时间给予光。 临床研究已经表明，通过基于现有技术的教导所预期的多个探针的光疗法的延长施用，肿瘤中的大量异常组织被破坏。 在该过程中，多个发光光纤或探针以间隔开的阵列展开。 光反应剂被异常组织吸收后，给予光疗至少3小时。 由于一种或多种伴随的作用，实现了肿瘤中更大量的坏死，包括：损伤的异常组织的炎症和患者身体的免疫反应; 活化光反应剂在预期通量区外的扩散和循环，据信会破坏异常组织; 预期注量区以外的逆行血栓形成或血管闭塞; 以及向期望注量区外的肿瘤部分提供氧合血液的血管系统的崩溃。 另外，扩展光疗期间扩散并循环到预期注量区的分子氧可能被转化为单线态氧，导致在预期注量区外部破坏异常组织的缺氧和缺氧的梯度。

公开(公告)号：US06304097B1

公开(公告)日：2001-10-16

申请号：US09757067

申请日：2001-01-08

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： G01R3128

CPC分类号： G01R31/3004 ,  G01R31/2884

摘要： A system, an IC chip, a test structure formed on the IC chip, and a corresponding method for modeling one or more target interconnect capacitances is disclosed. The test structure comprises an interconnect configuration comprising a test interconnect and one or more target interconnects. The interconnect configuration has, for each target interconnect, a corresponding target interconnect capacitance between the test interconnect and the target interconnect. The test structure also comprises a test interconnect charging circuit connected to the test interconnect. The test interconnect charging circuit is configured to place a test charge on the test interconnect. The test structure further comprises one or more target interconnect charging circuits. Each target interconnect charging circuit is connected to a corresponding target interconnect. Each target interconnect charging circuit is configured to draw a target interconnect charging current from the corresponding target interconnect in response to the test charge. This places an opposite charge on the corresponding target interconnect that is induced by the corresponding target interconnect capacitance. As a result, a measurement of the corresponding target interconnect capacitance may be computed by making a measurement of the target interconnect charging current with a current meter of the system.

公开(公告)号：US06281611B1

公开(公告)日：2001-08-28

申请号：US09548385

申请日：2000-04-11

申请人： James C. Chen ,  Darrin Huston

发明人： James C. Chen ,  Darrin Huston

IPC分类号： H05B610

CPC分类号： H05B6/1236 ,  A47J36/02 ,  A47J36/26 ,  A61F2250/0001 ,  A61N1/08 ,  A61N1/3787 ,  H01F38/12 ,  H01F38/14 ,  H02K5/1282 ,  H02K7/1807 ,  H02K7/1876 ,  H02K21/12 ,  H02K21/24 ,  H02K35/02 ,  Y02B40/123

摘要： A method and apparatus for heating substances such as beverages, soups, chemicals, etc., with heat produced by circulating electrical eddy currents. In one form of the device, a magnetic flux generating base produces a varying magnetic field by using an electric motor to move a plurality of permanent magnets. The varying magnetic field induces the eddy currents to circulate in a ferromagnetic conductor that is sealed in the bottom of a container resting on the magnetic flux generating base. Losses due to the eddy current produce heat that is transferred into the substance within the container. In another embodiment, the motor moves one or more magnetic flux shunts to vary the magnetic field experienced by the ferromagnetic conductor. The presence of the container on the magnetic flux generating base can be detected and used to control the operation of the electrical motor. An indicator is provided in one embodiment to alert a user when the electrical motor is energized and the substance in the container is being heated.

摘要翻译： 一种用于通过循环电涡流产生的热量来加热诸如饮料，汤，化学品等物质的方法和装置。 在该装置的一种形式中，磁通量产生基座通过使用电动机来移动多个永磁体来产生变化的磁场。 变化的磁场引起涡电流在密封在位于磁通量产生基座上的容器底部的铁磁导体中循环。 由于涡流产生的损失产生转移到容器内物质的热量。 在另一个实施例中，电机移动一个或多个磁通分流器，以改变铁磁导体所经历的磁场。 可以检测容器在磁通量产生基座上的存在并用于控制电动机的操作。 在一个实施例中提供指示器，以在电动机通电并且容器中的物质被加热时警告用户。

公开(公告)号：US6092531A

公开(公告)日：2000-07-25

申请号：US325022

申请日：1999-06-03

申请人： James C. Chen ,  David J. Brown ,  Darrin Huston ,  Brian D. Wilkerson

发明人： James C. Chen ,  David J. Brown ,  Darrin Huston ,  Brian D. Wilkerson

IPC分类号： A61F2/02 ,  A61N1/08 ,  A61N1/378 ,  H02J17/00 ,  H05B6/12 ,  A61M37/00 ,  H02K33/00

CPC分类号： A61N1/3787 ,  A61N1/08 ,  A61F2250/0001

摘要： An external power head is energized by a motor causing movement of an element that produces a varying magnetic field, thereby inducing power in an implanted receiver coil within a patient's body. The external power head includes either one or more moving permanent magnets, or one or more moving elements that vary the magnetic flux coupled to the implanted receiver coil. As a result of the varying magnetic field experienced by the implanted receiver coil, an electric current flows from the implanted receiver coil to energize an implanted medical device.

摘要翻译： 外部动力头由电动机激励，引起产生变化的磁场的元件的运动，从而在患者体内的植入的接收器线圈中引起电力。 外部动力头包括一个或多个移动永磁体，或者一个或多个移动元件，其改变耦合到植入的接收器线圈的磁通量。 由于植入的接收器线圈所经历的变化的磁场的结果，电流从植入的接收器线圈流动以对植入的医疗装置通电。

公开(公告)号：US5702432A

公开(公告)日：1997-12-30

申请号：US725578

申请日：1996-10-03

申请人： James C. Chen ,  Brent Wiscombe

发明人： James C. Chen ,  Brent Wiscombe

IPC分类号： A61M1/36 ,  A61N5/06 ,  A61N00/00

CPC分类号： A61N5/062 ,  A61N5/0601

摘要： A method and apparatus for administering intracorporeal photopheresis to blood flowing in a patient's body to destroy an undesirable component in the blood, where the undesirable component has absorbed a photoreactive agent having a characteristic light absorption waveband. The apparatus includes an implantable housing that is adapted to be placed transcutaneously within a patient's body. An inlet and outlet for a fluid path through the housing are provided and are coupled to a patient's circulatory system so that they convey blood into and out of the housing. Light sources disposed within the housing(or externally disposed and coupled to the housing by optical fibers) emit light having a waveband substantially equal to the absorption waveband of the photoreactive agent. A portion of the fluid path within the housing is optically transparent so that blood is irradiated with light from the light source. The fluid path can have one of several different configurations, including serpentine, planar coil, helical coil, and cross tubes coupling inlet and outlet header manifolds. The light source can comprise light emitting diodes (LEDs) or other types of light sources and may be coupled to the reactor through optical fibers. The power supply for the light source can be intracorporeal or extracorporeal.

摘要翻译： 一种用于对在患者体内流动的血液进行体内光泳术以破坏血液中不期望的组分的方法和装置，其中不希望的组分已经吸收了具有特征性光吸收波段的光反应剂。 该装置包括可植入的壳体，其适于经皮地放置在患者体内。 提供了通过壳体的流体路径的入口和出口，并且连接到患者的循环系统，使得它们将血液输入和移出壳体。 设置在壳体内（或者通过光纤外部设置并耦合到壳体）的光源发射具有基本上等于光反应剂的吸收波段的波段的光。 壳体内的流体路径的一部分是光学透明的，从而用来自光源的光照射血液。 流体路径可以具有几种不同构造中的一种，包括蛇形，平面线圈，螺旋线圈和耦合入口和出口集管歧管的交叉管。 光源可以包括发光二极管（LED）或其他类型的光源，并且可以通过光纤耦合到反应器。 光源的电源可以是体内或体外。