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    STENTS WITH DRUG ELUTING COATINGS
    31.
    发明申请
    STENTS WITH DRUG ELUTING COATINGS 审中-公开
    带药液涂层的手套

    公开(公告)号：US20080281409A1

    公开(公告)日：2008-11-13

    申请号：US11933517

    申请日：2007-11-01

    申请人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    发明人： Anthony Malone ,  Tim O'Connor ,  Dave McMorrow ,  Aiden Flanagan

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622

    摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.

    摘要翻译： 提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。 具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。 医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治​​疗区域。 医疗装置适于插入或植入受试者，优选人。 还提供了制备和使用涂覆的医疗装置的方法。

    Magnetic particles for delivering therapeutic agent to a target location
    34.
    发明授权
    Magnetic particles for delivering therapeutic agent to a target location 有权
    用于将治疗剂递送至目标位置的磁性颗粒

    公开(公告)号：US08550089B2

    公开(公告)日：2013-10-08

    申请号：US12765369

    申请日：2010-04-22

    申请人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David J. Sogard ,  Liza J. Davis

    发明人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David J. Sogard ,  Liza J. Davis

    IPC分类号： A61B19/00

    CPC分类号： A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

    摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

    摘要翻译： 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

    MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION
    36.
    发明申请
    MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 有权
    用于将治疗药物递送至目标位置的磁性颗粒

    公开(公告)号：US20100269838A1

    公开(公告)日：2010-10-28

    申请号：US12765369

    申请日：2010-04-22

    申请人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David Sogard ,  Liza Davis

    发明人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David Sogard ,  Liza Davis

    IPC分类号： A61B19/00

    CPC分类号： A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

    摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

    摘要翻译： 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

    MEDICAL DEVICES COATED WITH POROUS CARBON AND METHODS OF MANUFACTURING THE SAME
    37.
    发明申请
    MEDICAL DEVICES COATED WITH POROUS CARBON AND METHODS OF MANUFACTURING THE SAME 审中-公开
    涂有多孔碳的医疗装置及其制造方法

    公开(公告)号：US20100161037A1

    公开(公告)日：2010-06-24

    申请号：US12718410

    申请日：2010-03-05

    申请人： Aiden Flanagan

    发明人： Aiden Flanagan

    IPC分类号： A61F2/82

    CPC分类号： A61L31/084 ,  A61L31/146

    摘要： A method of creating a porous carbon coating on a medical device by applying a precursor carbon material on the medical device and then pyrolysing the precursor carbon material by laser irradiation. The laser irradiation may be focused to carbonize only certain portions of the medical device and any uncarbonized areas can be removed by solvent washing. Also provided is a medical device having a carbonized coating created according to the method of the present invention.

    摘要翻译： 一种通过在医疗装置上施加前体碳材料然后通过激光照射来热解前体碳材料在医疗装置上形成多孔碳涂层的方法。 可以聚焦激光照射以仅将医疗装置的某些部分碳化，并且通过溶剂洗涤可以去除任何未碳化的区域。 还提供了具有根据本发明的方法制造的碳化涂层的医疗装置。

    BIOABSORBABLE STENT
    38.
    发明申请
    BIOABSORBABLE STENT 审中-公开
    生物耐药性

    公开(公告)号：US20100125328A1

    公开(公告)日：2010-05-20

    申请号：US12690758

    申请日：2010-01-20

    申请人： Aiden Flanagan

    发明人： Aiden Flanagan

    IPC分类号： A61F2/82

    CPC分类号： A61F2/82 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/148

    摘要： A medical device includes a support structure formed of a metal that is absorbable by a mammalian body. A polymer is disposed on the support structure in at least partially overlying relationship. The polymer has a thickness and a rate of absorption by a mammalian body such that said polymer is substantially completely absorbed, exposing the underlying portion of the support structure, before the underlying portion of the support structure is absorbed. In another embodiment, the medical device includes a support structure formed of a first material, the first material being absorbable by a mammalian body. An absorption inhibitor disposed on the support structure in at least partially overlying relationship and formed of a second material different from the first material. The second material being absorbable by the mammalian body The absorption inhibitor reducing a rate of absorption of the portion of the support structure.

    摘要翻译： 医疗装置包括由可被哺乳动物体吸收的金属形成的支撑结构。 聚合物以至少部分上覆的关系设置在支撑结构上。 聚合物具有哺乳动物体的厚度和吸收速率，使得所述聚合物基本上被完全吸收，在支撑结构的下面的部分被吸收之前暴露于支撑结构的下面部分。 在另一个实施例中，医疗装置包括由第一材料形成的支撑结构，第一材料可由哺乳动物身体吸收。 一种吸收抑制剂，其以至少部分上覆的关系设置在所述支撑结构上，并且由不同于所述第一材料的第二材料形成。 哺乳动物体可吸收的第二种物质吸收抑制剂降低支持结构部分的吸收速率。

    MEDICAL DEVICES HAVING COATINGS FOR THERAPEUTIC AGENT DELIVERY
    39.
    发明申请
    MEDICAL DEVICES HAVING COATINGS FOR THERAPEUTIC AGENT DELIVERY 有权
    具有用于治疗药物递送的涂层的医疗装置

    公开(公告)号：US20100055151A1

    公开(公告)日：2010-03-04

    申请号：US12544679

    申请日：2009-08-20

    申请人： Aiden Flanagan

    发明人： Aiden Flanagan

    IPC分类号： A61F2/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/61 ,  A61N1/05 ,  A61N1/375

    摘要： According to an aspect of the invention, implantable and insertable medical devices are provided that include (a) a substrate, (b) a porous layer comprising interconnected pores disposed over the substrate, (c) at least one first therapeutic agent disposed within and/or beneath the porous layer, (d) a composite layer disposed over the porous layer that includes (i) at least one therapeutic agent eluting region containing at least one second therapeutic agent and at least one matrix material and (ii) at least one bioerodible region containing at least one bioerodible material that extends from the surface of the composite layer to the porous layer.

    摘要翻译： 根据本发明的一个方面，提供了可植入和可插入的医疗装置，其包括（a）基底，（b）包含设置在基底上的互连孔的多孔层，（c）至少一个第一治疗​​剂， 或多孔层之下，（d）设置在多孔层上的复合层，其包括（i）至少一种含有至少一种第二治疗剂和至少一种基质材料的治疗剂洗脱区，和（ii）至少一种生物可蚀解 区域包含从复合层的表面延伸到多孔层的至少一种生物可蚀解材料。