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45 条记录 (耗时 0.024 秒)

    Automated acquisition of spectral data and image data
    32.
    发明申请
    Automated acquisition of spectral data and image data 有权
    自动采集光谱数据和图像数据

    公开(公告)号：US20070133984A1

    公开(公告)日：2007-06-14

    申请号：US11585535

    申请日：2006-10-24

    申请人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： H04B10/08 ,  H04B17/00

    CPC分类号： G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    Method and apparatus for peak compensation in an optical filter
    33.
    发明申请
    Method and apparatus for peak compensation in an optical filter 有权
    光学滤波器中峰值补偿的方法和装置

    公开(公告)号：US20060001881A1

    公开(公告)日：2006-01-05

    申请号：US10879630

    申请日：2004-06-30

    申请人： John Maier ,  Jason Neiss ,  Shona Stewart

    发明人： John Maier ,  Jason Neiss ,  Shona Stewart

    IPC分类号： G01J3/51

    CPC分类号： G01J3/28 ,  G01J3/0227 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/44

    摘要： In one embodiment the disclosure relates to a method and a system for determining the corrected wavelength of a photon scattered by a sample. The method includes the steps of determining a wavelength of a photon scattered from a sample exposed to illuminating photons and passed through a tunable filter and correcting the determined wavelength of the photon as a function of the temperature of the tunable filter and as a function of the bandpass set point of the tunable filter. The step of correcting the determined wavelength can further include determining an offset and adding the offset to the determined wavelength of the photon.

    摘要翻译： 在一个实施例中，本公开涉及一种用于确定由样本散射的光子的校正波长的方法和系统。 该方法包括以下步骤：确定从暴露于照射光子的样品散射的光子的波长，并且通过可调谐滤光器并校正所确定的光子波长作为可调滤光器的温度的函数，并且作为 可调谐滤波器的带通设定点。 校正所确定的波长的步骤还可以包括确定偏移并将偏移量加到所确定的光子的波长上。

    System and method for diagnosis tissue samples using fluorescence and raman techniques
    34.
    发明申请
    System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
    使用荧光和拉曼技术诊断组织样本的系统和方法

    公开(公告)号：US20120078524A1

    公开(公告)日：2012-03-29

    申请号：US13136366

    申请日：2011-07-29

    申请人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    发明人： Shona Stewart ,  Jeffrey Cohen ,  Amy Drauch ,  John Maier

    IPC分类号： G01N33/48 ,  G01N21/64 ,  G01J3/44

    CPC分类号： A61B5/0059 ,  A61B5/417 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/6458 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/16 ,  G02B21/365 ,  G06F19/325 ,  G16H50/70

    摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.

    摘要翻译： 用于确定测试生物样品的诊断的系统和方法。 一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生 所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。 一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。 可以评估该拉曼数据集以确定样品的诊断。 诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging
    35.
    发明授权
    Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging 有权
    使用拉曼分子成像区分浸润性导管癌和浸润性小叶癌

    公开(公告)号：US07956996B2

    公开(公告)日：2011-06-07

    申请号：US12206500

    申请日：2008-09-08

    申请人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    发明人： John Maier ,  Jeffrey Cohen ,  Shona Stewart

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/02 ,  A61B5/0059 ,  A61B5/417 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  Y02A90/26

    摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

    摘要翻译： 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳样品以产生散射的光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

    Automated acquisition of spectral data and image data
    36.
    发明授权
    Automated acquisition of spectral data and image data 有权
    自动采集光谱数据和图像数据

    公开(公告)号：US07557915B2

    公开(公告)日：2009-07-07

    申请号：US11585535

    申请日：2006-10-24

    申请人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    发明人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

    IPC分类号： G01J3/44

    CPC分类号： G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

    摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

    摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

    System and method for serum based cancer detection
    38.
    发明授权
    System and method for serum based cancer detection 有权

    公开(公告)号：US11145411B2

    公开(公告)日：2021-10-12

    申请号：US14440987

    申请日：2013-11-06

    申请人： CHEMIMAGE CORPORATION ,  Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

    发明人： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

    IPC分类号： G01N21/65 ,  G01N33/49 ,  G16H50/20 ,  G16B40/00 ,  G01N33/574 ,  G01J3/44 ,  G01J3/18

    摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

    Cytological analysis by raman spectroscopic imaging
    39.
    发明授权
    Cytological analysis by raman spectroscopic imaging 有权
    通过拉曼光谱成像进行细胞学分析

    公开(公告)号：US08553732B2

    公开(公告)日：2013-10-08

    申请号：US12755463

    申请日：2010-06-23

    申请人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    发明人： John Maier ,  Joseph Demuth ,  Jeffrey Cohen ,  Shona Stewart ,  Lindy McClelland

    IPC分类号： H01S3/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  G01N21/65

    摘要： A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.

    摘要翻译： 一种产生样品图像的方法，其用于提供样品中细胞的疾病状态。 用单色光照射包含电池的样品。 评估拉曼散射光。 产生拉曼散射光的数字明场图像，并与细胞发射的拉曼散射光组合，由此拉曼散射光提供样品中细胞的疾病状态。 该方法还可以用于确定细胞的代谢活性，细胞的炎性状态和/或样品中细胞的感染状态。