公开(公告)号：US08323760B2

公开(公告)日：2012-12-04

申请号：US13473354

申请日：2012-05-16

申请人： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

发明人： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

IPC分类号： B29D23/00 ,  A61F2/04

CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/825 ,  A61F2230/0013 ,  A61F2250/0036 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/139 ,  C08L67/04

摘要： Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

公开(公告)号：US20120094932A1

公开(公告)日：2012-04-19

申请号：US13333573

申请日：2011-12-21

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC分类号： A61K31/436 ,  A61K31/616 ,  A61K31/5415 ,  A61K31/542 ,  A61P7/02 ,  A61K38/13 ,  A61P35/00 ,  A61P37/00 ,  A61P29/00 ,  A61P37/06 ,  A61K31/727 ,  A61K31/573

CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.

公开(公告)号：US20120071962A1

公开(公告)日：2012-03-22

申请号：US12965080

申请日：2010-12-10

申请人： Howard Huang ,  John Yan ,  Vinayak Bhat ,  Motasim Sirhan

发明人： Howard Huang ,  John Yan ,  Vinayak Bhat ,  Motasim Sirhan

IPC分类号： A61F2/82

CPC分类号： A61F2/915 ,  A61F2/848 ,  A61F2/91 ,  A61F2/958 ,  A61F2002/3011 ,  A61F2220/0016 ,  A61F2230/0002 ,  A61F2230/0006 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606

摘要： Stents are provided with scaffold structures which have low exposures when implanted in arteries and other blood vessels and lumens. The cross-sectional dimensions, materials, and patterns are controlled to provide sufficient strength and coverage while maintaining the low exposure.

摘要翻译： 支架设置有植入动脉和其他血管和腔内时具有低曝光量的支架结构。 控制横截面尺寸，材料和图案以提供足够的强度和覆盖，同时保持低曝光。

公开(公告)号：US07867988B2

公开(公告)日：2011-01-11

申请号：US11854312

申请日：2007-09-12

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC分类号： A61K31/365 ,  A61K31/4353 ,  A61K31/436

CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

摘要： A method of inhibiting smooth muscle cell proliferation or cytokine production in a subject, comprising administering a compound disclosed herein to the subject, is provided. The compound can be administered systemically, locally, or a combination thereof. For example, the compound can be locally delivered from a temporary device or an implant, such as a vascular prosthesis.

摘要翻译： 提供一种抑制受试者平滑肌细胞增殖或细胞因子产生的方法，包括将本文公开的化合物施用于受试者。 化合物可以全身，局部施用或其组合施用。 例如，化合物可以从临时装置或植入物如血管假体局部递送。

公开(公告)号：US07490988B1

公开(公告)日：2009-02-17

申请号：US12051657

申请日：2008-03-19

申请人： John Yan

发明人： John Yan

IPC分类号： G01D18/00

CPC分类号： A61B6/585 ,  A61B6/50 ,  A61B6/502 ,  A61B6/545 ,  Y10S378/901

摘要： Certain embodiments of the present invention provide methods and systems for calibrating a pixel spacing attribute value for X-ray mammography imaging based on a patient-specific breast thickness value. Certain embodiments provide a method for patient specific pixel spacing calibration for mammography X-ray imaging. The method includes determining a patient specific breast thickness value for a particular patient being imaged by a mammography X-ray device having a radiation source and a detector and an associated imager pixel spacing value. The method also includes calibrating a pixel spacing attribute for a mammography X-ray image based on the patient specific breast thickness value, a radiation source to detector distance in the mammography X-ray device, and the image pixel spacing value.

摘要翻译： 本发明的某些实施例提供了用于基于患者特异性乳房厚度值校准用于X射线乳房X线照相成像的像素间隔属性值的方法和系统。 某些实施例提供用于乳房X线照相X射线成像的患者特异性像素间隔校准的方法。 该方法包括确定由具有辐射源和检测器的乳房照相X射线装置以及相关联的成像器像素间隔值对正在成像的特定患者的患者特定乳房厚度值。 该方法还包括基于患者特定乳房厚度值，在乳房照相X射线装置中的检测器距离的辐射源和图像像素间隔值来校准用于乳房X线照相X射线图像的像素间隔属性。

公开(公告)号：US07238168B2

公开(公告)日：2007-07-03

申请号：US10080920

申请日：2002-02-20

申请人： Motasim Sirhan ,  John Yan ,  Kevin Gertner

发明人： Motasim Sirhan ,  John Yan ,  Kevin Gertner

IPC分类号： A61M29/00 ,  A61B25/00

CPC分类号： A61M25/104 ,  A61M25/0023 ,  A61M25/10 ,  A61M2025/0183 ,  A61M2025/1004 ,  A61M2025/1015

摘要： An intravascular balloon catheter includes a tubular catheter body having a balloon structure removably mounted over the catheter body. The catheter body has a guidewire lumen, and the catheter body may be left in place within a patient's vasculature while the balloon structure is withdrawn and optionally a second balloon structure introduced over the catheter body. The catheter and methods of the present invention are particularly suitable for performing angioplasty and subsequent procedures, such as stent placement, which are best performed using successive interventional balloon structures.

摘要翻译： 血管内气囊导管包括具有可移除地安装在导管主体上的球囊结构的管状导管体。 导管主体具有导丝管腔，并且导管主体可以在患者的脉管系统中留在适当的位置，同时取出球囊结构并且可选地在导管主体上引入第二球囊结构。 本发明的导管和方法特别适用于执行血管成形术和随后的程序，例如支架放置，其最好使用连续的介入气囊结构进行。

公开(公告)号：US07163839B2

公开(公告)日：2007-01-16

申请号：US11116571

申请日：2005-04-27

申请人： John Yan ,  Yong Du ,  Bruce E. Symons

发明人： John Yan ,  Yong Du ,  Bruce E. Symons

IPC分类号： H01L21/44

CPC分类号： H01L25/50 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L25/0657 ,  H01L2224/05554 ,  H01L2224/32145 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2224/92247 ,  H01L2225/0651 ,  H01L2225/06555 ,  H01L2225/06575 ,  H01L2924/00014 ,  H01L2924/01006 ,  H01L2924/01023 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01082 ,  H01L2924/01087 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/15311 ,  H01L2924/15787 ,  H01L2924/181 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2924/00012 ,  H01L2224/32225 ,  H01L2224/45099 ,  H01L2224/05599

摘要： A multi-chip module and a method for manufacturing the multi-chip module. A first semiconductor chip is mounted to a support substrate and a second semiconductor chip is mounted to the first semiconductor chip. The second semiconductor chip has a smaller dimension than the first semiconductor chip. A spacer is coupled to the second semiconductor chip. Bonding pads on the first and second semiconductor chips are wirebonded to bonding pads on the support substrate. A third semiconductor chip is mounted to the spacer and bonding pads on the third semiconductor chip are wirebonded to bonding pads on the support substrate.

摘要翻译： 一种多芯片模块及其制造方法。 第一半导体芯片安装在支撑基板上，第二半导体芯片安装在第一半导体芯片上。 第二半导体芯片的尺寸比第一半导体芯片小。 间隔件耦合到第二半导体芯片。 第一和第二半导体芯片上的接合焊盘被引线键合到支撑衬底上的接合焊盘。 第三半导体芯片安装到间隔件上，并且第三半导体芯片上的接合焊盘被引线接合到支撑衬底上的接合焊盘。

公开(公告)号：US07131986B2

公开(公告)日：2006-11-07

申请号：US09872640

申请日：2001-05-31

申请人： Motasim Sirhan ,  John Yan ,  Kevin Gertner

发明人： Motasim Sirhan ,  John Yan ,  Kevin Gertner

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61M25/0023 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1004 ,  A61M2025/1015

摘要： An intravascular balloon catheter comprises a tubular catheter body having a balloon structure removably mounted over the catheter body. The catheter body has a guidewire lumen, and the catheter body may be left in place within a patient's vasculature while the balloon structure is withdrawn and optionally a second balloon structure introduced over the catheter body. The catheter and methods of the present invention are particularly suitable for performing angioplasty and subsequent procedures, such as stent placement, which are best performed using successive interventional balloon structures.

公开(公告)号：US20060229711A1

公开(公告)日：2006-10-12

申请号：US11398363

申请日：2006-04-04

申请人： John Yan ,  Motasim Sirhan ,  Brett Cryer ,  Vinayak Bhat

发明人： John Yan ,  Motasim Sirhan ,  Brett Cryer ,  Vinayak Bhat

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61F2/02 ,  A61F2/06 ,  A61F2/07 ,  A61F2/90 ,  A61F2210/0004 ,  A61F2220/0058 ,  A61F2250/003 ,  A61F2250/0067 ,  B23K26/0006 ,  B23K26/0624 ,  B23K26/355 ,  B23K26/382 ,  B23K26/40 ,  B23K2101/06 ,  B23K2103/02 ,  B23K2103/12 ,  B23K2103/50

摘要： Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.

摘要翻译： 提供了用于可临床相关时间段可降解的可植入医疗装置的装置和方法。 医疗装置可以具有植入物，移植物植入物，血管植入物，非血管植入物，伤口闭合植入物，缝线，药物递送植入物，生物递送植入物，尿道植入物，子宫内植入物，器官植入物，包括骨骼的骨植入物 板，骨螺钉，牙植入物，脊椎盘等。 在优选实施例中，可植入医疗装置包括可植入腔内假体，例如血管和非血管支架和支架移植物。

公开(公告)号：US20050131532A1

公开(公告)日：2005-06-16

申请号：US11009657

申请日：2004-12-10

申请人： Motasim Sirhan ,  John Yan

发明人： Motasim Sirhan ,  John Yan

IPC分类号： A61K9/00 ,  A61F2/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/84 ,  A61F2/90 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16

CPC分类号： A61L27/54 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602

摘要： The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention provides luminal prostheses which allow for a programmed and controlled substance delivery protocols for a variety of purposes. The prostheses comprise a scaffold which is implantable within a body lumen and a substance reservoir present over at least a portion of the scaffold. Usually, a rate-controlling element will be formed over the substance-containing reservoir to provide for a number of different substance release characteristics.

摘要翻译： 本发明提供了用于将物质递送到血管和其他腔内和体内环境的改进的支架和其他假体。 特别地，本发明提供了腔体假体，其允许用于各种目的的编程和受控物质递送方案。 假体包括可植入体腔内的支架和存在于支架的至少一部分上的物质储存器。 通常，在含物质储存器上形成速率控制元件以提供许多不同的物质释放特性。