公开(公告)号：US20150164385A1

公开(公告)日：2015-06-18

申请号：US14261077

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  G01N21/00 ,  G01N33/49 ,  G01N27/416 ,  A61B5/1455 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

Abstract translation: 用于传感器校准和传感器葡萄糖（SG）融合的方法和系统有利地用于提高正交冗余葡萄糖传感器装置的精度和可靠性，其可以包括光学和电化学葡萄糖传感器。 可以通过固定偏移和/或动态回归方法来实现两个传感器的校准，这取决于例如传感器稳定性和Isig-Ratio对相关性。 对于SG融合，可以对来自光学和电化学传感器的SG值执行相应的完整性检查，并且如果通过完整性检查，校准SG值。 完整性检查可能包括检查灵敏度损失，噪声和漂移。 如果完整性检查失败，则可以在校准之前执行电化学和光学传感器之间的在线传感器映射。 电化学和光学SG值可以被加权（作为各个传感器的整体可靠性指数（RI）的函数），并且加权的SG组合以获得单个融合的SG值。

公开(公告)号：US20240345011A1

公开(公告)日：2024-10-17

申请号：US18735347

申请日：2024-06-06

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: A method of optimizing operation of a glucose sensor includes performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for an electrode of a glucose sensor, calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value, and obtaining measurements of the calibration factor for the glucose sensor. The method also includes comparing the change value to a first threshold and the calibration factor to a second threshold and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

公开(公告)号：US11974844B2

公开(公告)日：2024-05-07

申请号：US16397156

申请日：2019-04-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/7221 ,  A61B5/1451 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20220354394A1

公开(公告)日：2022-11-10

申请号：US17859427

申请日：2022-07-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: The disclosed techniques include obtaining a first signal generated by an electrochemical glucose sensor and a second signal generated by an optical glucose sensor, and obtaining a glucose value indicative of a user's blood glucose level, where the glucose value and the second signal are obtained at different times. The disclosed techniques further cause calculating a mapped value for the second signal based on the first signal, and calibrating the mapped value of the second signal based on the glucose value.

公开(公告)号：US20220262475A1

公开(公告)日：2022-08-18

申请号：US17661674

申请日：2022-05-02

Applicant: Medtronic MiniMed, Inc.

Inventor： Keith Nogueira ,  Pratik J. Agrawal ,  Brian T. Kannard ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Yuxiang Zhong

IPC: G16H20/17 ,  A61M5/172 ,  G05B15/02 ,  A61M5/142

Abstract: Disclosed herein are techniques related to adaptive signal processing. The techniques may involve: obtaining a plurality of unfiltered measurement values based on signals generated by a sensor; determining a plurality of filtered measurement values based on the plurality of unfiltered measurement values; determining, based on the plurality of filtered measurements, a first derivative metric for a current filtered measurement of the plurality of filtered measurements and a second derivative metric for the current filtered measurement; determining an output filtered measurement indicative of a physiological condition of a user based at least in part on the current filtered measurement, the first derivative metric, the second derivative metric, and a previous output measurement; and outputting the output filtered measurement.

公开(公告)号：US10772540B2

公开(公告)日：2020-09-15

申请号：US16241591

申请日：2019-01-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Xiaolong Li ,  Bradley Chi Liang

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  C25D17/12 ,  C25D5/18 ,  C25D5/02 ,  C25D3/50

Abstract: Embodiments of the invention provide analyte sensors having optimized electrodes and/or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US20190246961A1

公开(公告)日：2019-08-15

申请号：US16397156

申请日：2019-04-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20190167170A1

公开(公告)日：2019-06-06

申请号：US16266385

申请日：2019-02-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/00 ,  G01N27/327 ,  G01N21/84 ,  G01N21/00 ,  G01N33/66 ,  C12Q1/00 ,  A61B5/1455 ,  A61B5/1468 ,  A61M5/142 ,  G01N33/49 ,  G01N27/416 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1459 ,  A61M5/172 ,  G01N27/27 ,  G01N21/59

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US10194840B2

公开(公告)日：2019-02-05

申请号：US13707400

申请日：2012-12-06

Applicant: Medtronic MiniMed, Inc.

Inventor： Daniel E. Pesantez ,  Xiaolong Li ,  Bradley Chi Liang

IPC: A61B5/145 ,  A61B5/1486 ,  C12Q1/00

Abstract: Embodiments of the invention provide analyte sensors having optimized electrodes and/or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US10039479B2

公开(公告)日：2018-08-07

申请号：US15428589

申请日：2017-02-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1495

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.