摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslip idemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要:
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要:
Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Also provided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
摘要:
Improved mask layout patterns are described for closely spaced primitives in phase shift photolithography masks. In one example, at least a portion of a photolithography mask layout is decomposed into primitives. Jogs are identified from among the primitives, the jogs being characterized by three adjacent corners. E-fields are determined for the identified jogs and are applied to synthesize an electric field at a substrate. The mask layout is corrected using the synthesized electric field and a printed wafer pattern is calculated.
摘要:
A method, a system and computer readable storage media facilitate receiving a data stream from a host media server that is outside of a network, designating a multicasting source within the network to receive the data stream from the host media server, and multicasting the data stream from the multicasting source to a plurality of client devices within the network.
摘要:
The present invention relates to a method and system for automatically identifying various information of a train. The method comprises using sensors to collect wheelbase information, processing the information by signal data processing devices, thereby providing information of a train, namely: arranging a plurality of sensors along the rail in the incoming direction of the train, dividing the sensors into at least three groups, each group comprising at least two sensors; analyzing and processing the signal data stream obtained from the sensors and collected when a train vehicle passes by, thereby acquiring the speed and wheelbase of the train, and further acquiring the train segmentation information; determining the vehicle type; acquiring hook locating information; determining the train arrival; determining the train departure; acquiring vehicle number. The present invention further comprises a system for carrying out the information method for automatically identifying information of a train. The present invention can provide a plurality of types of train information with high accuracy, and is easy to be carried out.
摘要:
Described herein is mask design and modeling for a set of masks to be successively imaged to print a composite pattern on a substrate, such as a semiconductor wafer. Further described herein is a method of double patterning a substrate with the set of masks. Also described herein is a method of correcting a drawn pattern of one of the mask levels based on a predicted pattern contour of the other of the mask levels. Also described herein is a method of modeling a resist profile contour for a mask level in which photoresist is applied onto a inhomogeneous substrate, as well as method of predicting a resist profile of a Boolean operation of two masks.
摘要:
An ultrapure colloidal silica dispersion comprising colloidal silica particles having a mean or aggregate particle size from about 10 to about 200 nm, wherein the colloidal silica dispersion has less than 200 ppb, of each trace metal impurity disposed therein, excluding potassium and sodium, and have less than 2 ppm residual alcohol. A method for producing and using the same is also disclosed.
摘要:
A writing system includes a pen with a two-dimensional optical sensor and a three dimensional acceleration sensor positioned to indicate movement of the pen. A calibrator is coupled to receive path coordinate signals from the two-dimensional optical sensor and the three dimensional acceleration sensor. The calibrator and the two-dimensional optical sensor and the three dimensional acceleration sensor are configured to operate in one of two modes, a contactable mode of operation wherein both the two-dimensional optical sensor and the three dimensional acceleration sensor supply path coordinate signals to the coordinator and a contactless mode of operation wherein only the three dimensional acceleration sensor supplies path coordinate signals to the coordinator.