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公开(公告)号：US08518713B2
公开(公告)日：2013-08-27
申请号：US13495208
申请日：2012-06-13
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B82Y15/00 , G01N21/763 , G01N33/588
摘要： Generally, conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like, are described herein.
摘要翻译： 通常，本文描述共轭体系，自发光量子点共轭体，检测宿主中靶标的方法，治疗宿主疾病的方法等。
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公开(公告)号：US07939649B2
公开(公告)日：2011-05-10
申请号：US11995586
申请日：2006-09-06
CPC分类号： C12Q1/66
摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.
摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。
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33.发明授权Protein phosphorylation imaging systems, methods of making phosphorylation imaging systems, and methods of use thereof 有权蛋白质磷酸化成像系统，制备磷酸化成像系统的方法及其使用方法公开(公告)号：US07834148B2
公开(公告)日：2010-11-16
申请号：US11805425
申请日：2007-05-23
IPC分类号： C07K1/00
CPC分类号： C12Q1/66 , C07K2319/60 , C12N15/62 , C12Q1/485
摘要： Briefly described, embodiments of this disclosure include phosphorylation sensing systems, methods of detecting phosphorylation, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, fusion proteins including the phosphorylation sensing system, vectors including the phosphorylation sensing system, kits including the phosphorylation sensing system, transgenic cells including the phosphorylation sensing system, and the like are provided.
摘要翻译： 简要描述，本公开的实施方案包括磷酸化感测系统，检测磷酸化的方法，用于检测活体动物中第一蛋白质与第二蛋白质的相互作用的非侵入性方法，包括磷酸化感测系统的融合蛋白，包含磷酸化感测系统的载体 ，提供了包括磷酸化感测系统的试剂盒，包括磷酸化感测系统的转基因细胞等。
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34.发明申请MOLECULAR IMAGING OF LIVING SUBJECTS USING RAMAN SPECTROSCOPY AND LABELED RAMAN NANOPARTICLES 有权使用拉曼光谱和标签拉曼纳米粒子分析生物体的成像公开(公告)号：US20100166650A1
公开(公告)日：2010-07-01
申请号：US12598780
申请日：2008-05-05
申请人： Sanjiv S. Gambhir
发明人： Sanjiv S. Gambhir
CPC分类号： G01N21/658 , B82Y30/00
摘要： Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.
摘要翻译： 使用拉曼纳米颗粒成像活体的方法; 产生已经施用拉曼纳米粒子的活体的真实图像的方法; 使用多个拉曼纳米粒子对活体进行多重成像的方法; 通过将拉曼图像与其他功能/解剖图像组合来产生多模态图像的方法; 标记的拉曼纳米颗粒; 等等。
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公开(公告)号：US10517964B2
公开(公告)日：2019-12-31
申请号：US13406891
申请日：2012-02-28
摘要： Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.
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公开(公告)号：US08343458B2
公开(公告)日：2013-01-01
申请号：US12418116
申请日：2009-04-03
申请人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
发明人： Matthew S. Bogyo , Galia Blum , Alicia Berger , Zhen Cheng , Sanjiv S. Gambhir
CPC分类号： A61K51/08 , A61B6/508 , A61K49/0032 , A61K49/0056 , A61K51/0495 , A61K51/088
摘要： Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.
摘要翻译： 公开了基于活性的探针，其特异于某些活性半胱氨酸蛋白酶（半胱天冬酶，组织蛋白酶和legumain）和携带放射性标记。 本发明的探针包括只与活性酶结合的酰氧基甲基酮（AOMK）弹头。 探针进一步包含将探针靶向特定半胱氨酸蛋白酶或蛋白酶家族的肽样结构，以及与靶向酶结合的探针上的放射性标记。 已经发现本发明的探针在体内是稳定的，并且可以在背景下区分特定的目标图像。 优选的探针用正电子发射剂如64Cu，125I（SPECT）和99mTc（PET）标记。 探针显示体内半衰期和稳定性，非常适合成像。
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37.发明授权Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists 有权配体调节反式激活系统，其使用方法，检测雌激素受体配体的方法和分化雌激素受体配体激动剂和拮抗剂的方法公开(公告)号：US08076159B2
公开(公告)日：2011-12-13
申请号：US12658528
申请日：2010-02-10
IPC分类号： G01N33/566 , G01N33/53 , G01N33/567 , C12Q1/70 , C12Q1/66 , C12N5/00 , C12N5/07 , C12N5/10
CPC分类号： C12Q1/6897 , A01K2217/05 , A01K2267/0393 , C07K2319/00 , C12N2830/002 , G01N33/5008 , G01N33/542 , G01N33/743 , G01N2333/723 , Y10S436/814
摘要： Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable transactivation systems, reporter polynucleotides, method of producing reporter polynucleotides, activator fusion proteins, methods of producing activator fusion proteins, methods of regulating gene expression in vitro and in vivo for gene therapy, methods of screening estrogen receptor modulators with therapeutic treatments (e.g., anticancer, antiosteoporosis, and hormone replacement treatments), method of screening compounds (e.g., drugs and environmental pollutants) for the estrogenic effect, methods of evaluating the estrogen receptor pathway under different pathological conditions are provided, and the like.
摘要翻译： 简要描述，本公开的实施方案包括配体可调节反式激活系统，产生配体可调节反式激活系统的方法，使用配体可调节反式激活系统的方法，报告多核苷酸，产生报告多核苷酸的方法，活化融合蛋白，产生活化融合蛋白的方法 蛋白质，体外和体内基因治疗基因表达的方法，用治疗性治疗（例如抗癌，抗骨质疏松症和激素替代治疗）筛选雌激素受体调节剂的方法，筛选化合物（例如药物和环境污染物）的方法， 对于雌激素效应，提供了在不同病理条件下评价雌激素受体途径的方法等。
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38.发明授权Bioluminescence resonance energy transfer (BRET) systems and methods of use thereof 有权生物发光共振能量转移（BRET）系统及其使用方法公开(公告)号：US07842469B2
公开(公告)日：2010-11-30
申请号：US12365984
申请日：2009-02-05
申请人： Sanjiv S. Gambhir , Abhijit De
发明人： Sanjiv S. Gambhir , Abhijit De
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , C12Q1/66
摘要： Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the interaction of a first protein with a second protein in a living animal, BRET vectors, kits relating to each of the above, transgenic cell or progeny thereof and/or animals relating to each of the above, and the like.
摘要翻译： 简要描述，本公开的实施方案包括生物发光共振能量转移（BRET）系统，检测蛋白质 - 蛋白质相互作用的方法，用于检测活体动物中第一种蛋白质与第二种蛋白质的相互作用的非侵入性方法，确定功效的方法 施用以调节活体动物中第一蛋白质与第二蛋白质的相互作用的测试化合物，BRET载体，与上述每种相关的试剂盒，转基因细胞或其后代和/或与上述每种相关的动物，和/或 类似。
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公开(公告)号：US20100111871A1
公开(公告)日：2010-05-06
申请号：US12595525
申请日：2008-04-10
申请人： Sanjiv S. Gambhir , Levi Jelena , Shay Keren
发明人： Sanjiv S. Gambhir , Levi Jelena , Shay Keren
CPC分类号： G01N29/2418 , A61B5/0059 , A61B5/0095 , G01N29/0654 , G01N33/573 , G01N33/583 , G01N2291/014 , G01N2291/015 , G01N2291/0255
摘要： Embodiments of the present disclosure provide for photoacoustic probes, methods of determining the presence and location of a specific target, methods of determining the presence and location of an enzyme, methods of determining the presence and location of a specific target and an enzyme, and the like.
摘要翻译： 本公开的实施方案提供光声探测器，确定特定靶标的存在和位置的方法，确定酶的存在和位置的方法，确定特异性靶标和酶的存在和位置的方法，以及 喜欢。
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40.发明申请METHOD FOR NONINVASNELY AND QUANTITATIVELY MONITORING THERAPEUTIC AND DIAGNOSTIC TRANSGENE EXPRESSION INDUCED BY EX VNO AND IN VNO GENE TARGETING IN ORGANS, TISSUES AND CELLS 审中-公开用于在VNO和VNO基因靶向诱导的器官，组织和细胞中诱导的非维生素和定量监测治疗和诊断转移表达的方法公开(公告)号：US20090169474A1
公开(公告)日：2009-07-02
申请号：US12280680
申请日：2007-03-20
申请人： Luyi Sen , Sanjiv S. Gambhir
发明人： Luyi Sen , Sanjiv S. Gambhir
CPC分类号： C12Q1/6897
摘要： An composition in a method for noninvasively monitoring the expression of therapeutic transgene delivered ex vivo and in vivo for the treatment of diseases includes the step of quantitatively imaging a reporter gene expression which is coupled to a therapeutic gene on a plasmid vector to infer levels, location, or duration of the therapeutic gene expression in the targeted tissues or organs. The reporter gene is imaged using a radiopharmaceutical for scintigraphic imaging of the gene expression interactions with the reporter gene, namely positron emission tomography, gamma camera or single-photon emission computed tomography. The genes are delivered with a liposome encapsulated reporter-therapeutic linked transgene vector with balanced reporter/therapeutic transgene expression. A transgene composition includes the reporter gene linked to the therapeutic gene or genes incorporated in and delivered by a liposome encapsulated reporter-therapeutic linked transgene vector.
摘要翻译： 用于非侵入性监测离体和体内递送的用于治疗疾病的治疗性转基因表达的方法中的组合物包括定量成像与质粒载体上的治疗基因偶联的报告基因表达以推断水平，位置 或靶向组织或器官中治疗性基因表达的持续时间。 使用放射性药物对报告基因成像，用于与报告基因的基因表达相互作用的闪烁照相成像，即正电子发射断层扫描，γ照相机或单光子发射计算机断层扫描。 基因与具有平衡的报告基因/治疗性转基因表达的脂质体封装的报告基因治疗连接的转基因载体递送。 转基因组合物包括与治疗基因连接的报告基因或掺入脂质体封装的报告基因 - 治疗连锁的转基因载体并递送的基因。
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