公开(公告)号：US4556580A

公开(公告)日：1985-12-03

申请号：US685285

申请日：1984-12-24

申请人： Takashi Kamuro ,  Hisao Ootsuga ,  Isao Saito ,  Motoyuki Koga

发明人： Takashi Kamuro ,  Hisao Ootsuga ,  Isao Saito ,  Motoyuki Koga

IPC分类号： F16L55/16 ,  B05D7/22 ,  F16L55/10 ,  F16L55/1645 ,  F16L55/18 ,  F16L58/10 ,  G01M3/28 ,  B05D1/42

CPC分类号： G01M3/2853 ,  F16L55/10 ,  F16L55/1645 ,  F16L55/18

摘要： A method for repairing pipes laid underground, such as gas pipes, consisting of a main supply pipe from which numerous distribution pipes branch off to supply the individual users, the method using resin to repair the main supply pipe and the distribution pipes from the inside while in their buried state.The repair method of this invention is characterized by the fact that, having repaired the main supply pipe and the distribution pipe in successive operations, whether the repairs to the main supply pipe and the distribution pipes have been done properly or not can be confirmed on completion of the repairs by carrying out sealage tests on the distribution pipes and the main supply pipe.

摘要翻译： 一种用于修理地下管道的方法，例如气体管道，由主要供应管道组成，多个分配管从该主管道分流出来供应个体用户，使用树脂从内部维修主供应管道和分配管道的方法， 在他们的埋葬状态。 本发明的修理方法的特征在于，在连续操作中维修主供水管和分配管的情况下，是否已经完成了对主供水管和配水管的修理是否已经完成。 对配水管和主供水管进行密封试验。

公开(公告)号：US4513145A

公开(公告)日：1985-04-23

申请号：US457394

申请日：1983-01-12

申请人： Shigeto Negi ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Isao Saito ,  Kyosuke Kitoh

发明人： Shigeto Negi ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Isao Saito ,  Kyosuke Kitoh

IPC分类号： C07D311/22 ,  C07D501/36

CPC分类号： C07D311/22

摘要： A novel 2-methylchromone derivative represented by the general formula: ##STR1## wherein R.sub.1 means a hydrogen atom or a lower alkanoyl group. The above derivative is a useful intermediate for the synthesis of cephem activities, which are also effective against infections of the urinary tract, etc. A preparation process of the above chromone derivative is also disclosed.

摘要翻译： 由通式（I）表示的新型2-甲基色酮衍生物，其中R 1表示氢原子或低级烷酰基。 上述衍生物是合成头孢烯活性的有用中间体，其也有效地抵抗尿道感染等。上述色酮衍生物的制备方法也被公开。

公开(公告)号：US4161002A

公开(公告)日：1979-07-10

申请号：US862034

申请日：1977-12-19

申请人： Isao Saito

发明人： Isao Saito

IPC分类号： G11B15/18 ,  G11B21/02

CPC分类号： G11B15/1808

摘要： A battery-operable video tape recorder includes a rotary magnetic head which during normal operation is driven at a predetermined speed controlled by a servo circuit. In the pause mode of the recorder the rotary magnetic head is driven at a lower, uncontrolled speed to reduce power consumption. Release of the pause mode may be delayed until the servo circuit has locked following a pause.

摘要翻译： 电池可操作的磁带录像机包括旋转磁头，其在正常操作期间以由伺服电路控制的预定速度驱动。 在记录器的暂停模式下，旋转磁头以较低的不受控制的速度驱动以降低功耗。 可以延迟释放暂停模式，直到伺服电路在暂停之后锁定。

公开(公告)号：US20120318922A1

公开(公告)日：2012-12-20

申请号：US13579128

申请日：2011-01-06

申请人： Isao Saito ,  Tatsuo Ishiguro ,  Satoshi Mizukami

发明人： Isao Saito ,  Tatsuo Ishiguro ,  Satoshi Mizukami

IPC分类号： B64D15/04

CPC分类号： B64D15/04 ,  B64C3/28

摘要： A deicing device for a wing leading edge of an aircraft and an aircraft main wing are constituted by providing a hot air passage (46) by a curve-shaped main-wing leading edge (41) and a curve-shaped guide plate (42) arranged inside the main-wing leading edge (41) with a predetermined space therefrom, along an inner side of the main-wing leading edge (41), as well as by providing a duct pipe (47) that supplies bleed air to the hot air passage (46), in which in the hot air passage (46), a space at a distal end of the main-wing leading edge (41) is formed to be smaller than that on a downstream side in a bleed-air flowing direction. With this configuration, by heating a wing leading edge effectively, it is possible to appropriately prevent formation of ice adhering to an outer side of the wing leading edge.

摘要翻译： 用于飞行器和飞行器主翼的机翼前缘的除冰装置通过由曲线形的主翼前缘（41）和曲线形导板（42）提供热空气通道（46） 沿着所述主翼前缘（41）的内侧，沿着所述主翼前缘（41）设置有预定的空间，以及通过提供一个管道管（47），所述导管（47）向所述主翼前缘 在热风通道（46）中，在主翼前缘（41）的远端处的空间形成为比排气流动的下游侧的空气通道（46）小 方向。 通过这种构造，通过有效地加热机翼前缘，可以适当地防止粘附在机翼前缘的外侧的冰的形成。

公开(公告)号：US20080138817A1

公开(公告)日：2008-06-12

申请号：US11851602

申请日：2007-09-07

申请人： Hisafumi Ikeda ,  Isao Saito ,  Fumihiko Kitagawa

发明人： Hisafumi Ikeda ,  Isao Saito ,  Fumihiko Kitagawa

IPC分类号： C12Q1/68 ,  C07K14/47

CPC分类号： C07D487/04 ,  C07C245/08 ,  C07C271/20 ,  C07D311/80 ,  C09B11/08 ,  C09B11/24 ,  C09B69/00

摘要： A compound represented by general formula (I) below; (in the formula, A denotes B denotes R denotes H, NO2, NH2, NHCbz, Br, F, Cl or SO3Na2, and n is an integer of 1 to 4), and a process for producing the above compound characterised in that it includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ω-amino acid derivative.

摘要翻译： 由下述通式（I）表示的化合物; （式中，A表示B表示R表示H，NO 2，NH 2，NHCbz，Br，F，Cl或SO 3） Na 2，n为1〜4的整数），以及上述化合物的制造方法，其特征在于，其包括活化酯与叔丁氧基羰基氨基乙胺或ω-氨基 酸衍生物。

公开(公告)号：US07323555B2

公开(公告)日：2008-01-29

申请号：US10746157

申请日：2003-12-24

申请人： Isao Saito ,  Akimitsu Okamoto ,  Yasuko Yoshida

发明人： Isao Saito ,  Akimitsu Okamoto ,  Yasuko Yoshida

IPC分类号： C07H21/02 ,  C07H21/04 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07H19/067 ,  C07H21/04 ,  Y10S436/809

摘要： A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intensity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized, and which is (1) a thymine/uracil derivative emitting light most intensely when a confronting base in the partner strand with which the single-stranded nucleotide sequence is hybridized is adenine; (2) a cytosine derivative emitting light most intensely when the confronting base is guanine; (3) an adenine derivative emitting light most intensely when the confronting base is cytosine; and, (4) a guanine derivative emitting light most intensely when the confronting base is cytosine or thymine/uracil.

摘要翻译： 在存在单链序列成员的情况下，新的核苷酸衍生物根据与单链序列杂交的伴侣链中的相应碱基类型经历荧光信号强度的变化，并且其是 （1）当与单链核苷酸序列杂交的配对链中的相对碱基是腺嘌呤时，最强烈地发射光的胸腺嘧啶/尿嘧啶衍生物; （2）当对面的碱是鸟嘌呤时，最强烈地发射光的胞嘧啶衍生物; （3）当面对的碱基是胞嘧啶时，最强烈地发光的腺嘌呤衍生物; 和（4）当对面的碱基是胞嘧啶或胸腺嘧啶/尿嘧啶时，最强烈地发光的鸟嘌呤衍生物。

公开(公告)号：US07067622B2

公开(公告)日：2006-06-27

申请号：US10481275

申请日：2002-02-27

申请人： Hiroshi Sugiyama ,  Hirokazu Iida ,  Isao Saito ,  Takashi Saito

发明人： Hiroshi Sugiyama ,  Hirokazu Iida ,  Isao Saito ,  Takashi Saito

IPC分类号： C07K1/02

CPC分类号： C07D403/14

摘要： It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

摘要翻译： 本发明提供一种制备吡咯 - 咪唑聚酰胺的方法，其中可以方便地合成较长的吡咯 - 咪唑聚酰胺，并且可以容易地转移肽（蛋白质）。 根据该方法，可以在其末端从固相载体上切割出具有羧酸酯基的吡咯 - 咪唑聚酰胺，从而可以直接转移各种官能团，并且能够精确地区分DNA序列。 一种合成吡咯 - 咪唑聚酰胺的方法，其特征在于使用肽合成仪通过固相Fmoc法进行自动合成; 通过该方法得到的具有羧基的吡咯 - 咪唑聚酰胺; 具有在上述吡咯 - 咪唑聚酰胺末端转移到羧基中的DNA烷基化剂的吡咯 - 咪唑聚酰胺; 特征在于使用上述化合物的序列特异性DNA烷基化方法。

公开(公告)号：US06946455B2

公开(公告)日：2005-09-20

申请号：US10030678

申请日：2001-05-01

申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

IPC分类号： C12N15/00 ,  A61K31/407 ,  A61P35/00 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00 ,  C12N15/01 ,  C12N15/09 ,  A61K31/33 ,  A01N43/38 ,  A01N43/90 ,  A61K31/44 ,  C07D209/56

CPC分类号： C07D487/04 ,  C07D487/10

摘要： Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked: A-L-B-X-B-L-A  (I) wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.

摘要翻译： 由通式（I）表示的化合物：两个DNA链可以是交联的：<？in-line-formula description =“In-line Formulas”end =“lead”？> ALBXBLA（I） line-formula description =“In-line Formulas”end =“tail”？>其中B表示能识别DNA核苷酸序列的化学结构; A表示能够结合DNA的一个碱基的化学结构; L表示A和B的化学结构可以彼此连接的连接体; X表示可以将A-L-B成分彼此连接的间隔物。 通过使用这些化合物进行链间交联DNA的方法; 以及含有星际交联剂的DNA的药物组合物。

公开(公告)号：US20050142554A1

公开(公告)日：2005-06-30

申请号：US10508138

申请日：2002-08-15

申请人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

发明人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

IPC分类号： C07H19/14 ,  C07H19/04 ,  C07H19/22 ,  C07H19/23 ,  C07H21/04 ,  H01L51/30 ,  C12Q1/68 ,  C12M1/34

CPC分类号： C07H21/04 ,  B82Y10/00 ,  C07H19/04 ,  C07H19/22 ,  C07H19/23 ,  H01L51/0072 ,  H01L51/0093

摘要： A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I): (wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid); and a polynucleotide comprising the nucleic acid.

摘要翻译： DNA不会引起氧化分解的空穴传输核酸碱基; 以及能够在保持DNA的双螺旋结构的同时实现DNA中有效空穴传输的人造DNA分子。 提供：含有由通式（I）表示的苯并恶唑腺苷衍生物碱的核酸：其中R 1，R 2，R 3， R 3，R 5，R 5和R 6各自独立地表示氢，氨基，单（低级烷基）氨基，二（低级 烷基）氨基，羟基，低级烷氧基，卤代，氰基，巯基，低级烷硫基或芳基; R 7和R 8各自独立地表示氢或键合到 磷酸）; 和包含该核酸的多核苷酸。

公开(公告)号：US5770715A

公开(公告)日：1998-06-23

申请号：US618960

申请日：1996-03-20

申请人： Hiroshi Sugiyama ,  Ken Hatano ,  Isao Saito ,  Takayoshi Uchida ,  Yoko Matsuda ,  Kiyoshi Uchida

发明人： Hiroshi Sugiyama ,  Ken Hatano ,  Isao Saito ,  Takayoshi Uchida ,  Yoko Matsuda ,  Kiyoshi Uchida

IPC分类号： C07F9/204 ,  C07F9/24 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C07J63/00

CPC分类号： C07H19/10 ,  C07F9/204 ,  C07F9/2416 ,  C07H19/20 ,  C07H21/00 ,  C07J63/008

摘要： The present invention provides nucleic acid compounds which have a non-nucleic acid structure with ring skeleton to which two functional groups are bound with fixed state and are able to point to substantially the same direction, nucleic acid compounds which can form triple strands with third nucleotide chains, nucleic acid compounds which have improved permeability, and synthetic methods thereof.

摘要翻译： 本发明提供了具有环状骨架的非核酸结构的核酸化合物，两个官能团以固定状态结合并且能够指向基本上相同的方向，可以与第三核苷酸形成三链的核酸化合物 链，具有改善的渗透性的核酸化合物及其合成方法。