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    INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES
    32.
    发明申请
    INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES 有权
    具有外部光源的集成器件用于探测和分析分子

    公开(公告)号：US20160370292A1

    公开(公告)日：2016-12-22

    申请号：US15255303

    申请日：2016-09-02

    申请人： Quantum-Si Incorporated

    发明人： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

    IPC分类号： G01N21/64 ,  C12Q1/68

    CPC分类号： G01N21/6408 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/12

    摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.

    摘要翻译： 用于分析单分子和进行核酸测序的系统和方法。 集成器件包括多个像素，其中样品阱被配置为接收样品，当被激发时，它们发射辐射。 集成器件包括至少一个波导，其配置成从被配置为与激发能源耦合的集成器件的区域将激发能量传播到样品阱。 像素还可以包括用于将发射能量引导到像素内的传感器的至少一个元件。 该系统还包括与集成设备接口的仪器。 仪器可以包括用于通过耦合到集成器件的激发能量耦合区域来向集成器件提供激发能量的激发能源。 可以通过发射能量的时间参数区分的多个标记之一可以标记样本，并且像素内的传感器的配置可以允许检测与标记标本样品相关联的时间参数。

    OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING AND ANALYZING MOLECULE
    33.
    发明申请
    OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING AND ANALYZING MOLECULE 有权
    用于探测，分析和分析分子的光学系统和测试芯片

    公开(公告)号：US20160041095A1

    公开(公告)日：2016-02-11

    申请号：US14821686

    申请日：2015-08-07

    申请人： Quantum-Si Incorporated

    发明人： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Paul E. Glenn ,  Lawrence C. West ,  Benjamin Cipriany ,  Keith G. Fife

    IPC分类号： G01N21/64 ,  C12Q1/68

    CPC分类号： G01N21/6408 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2201/0446 ,  G01N2201/062

    摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

    摘要翻译： 用于分析单分子和进行核酸测序的装置和方法。 装置可以包括测定芯片，其包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射发射能量; 用于在特定方向上引导发射能量的至少一个元件; 以及发光能量从样品阱向传感器行进的光路。 该装置还包括与测定芯片接口的仪器。 仪器包括用于激发每个样品井中的样品的激发光源; 多个传感器对应于样品孔。 每个传感器可以检测来自相应样品阱中的样品的发射能量。 仪器包括至少一个光学元件，其将来自每个样品的发射能量引向多个传感器中的相应传感器。

    SENSOR FOR LIFETIME PLUS SPECTRAL CHARACTERIZATION
    34.
    发明公开
    SENSOR FOR LIFETIME PLUS SPECTRAL CHARACTERIZATION 审中-公开

    公开(公告)号：US20240353326A1

    公开(公告)日：2024-10-24

    申请号：US18539068

    申请日：2023-12-13

    申请人： Quantum-Si Incorporated

    发明人： Gerard Schmid ,  Dajiang Yang ,  Eric A.G. Webster ,  Xin Wang ,  Todd Rearick ,  Changhoon Choi ,  Ali Kabiri ,  Kyle Preston

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6439

    摘要： Some aspects relate to integrated devices for obtaining timing and/or spectral information from incident light. In some embodiments, a pixel may include one or more charge storage regions configured to receive charge carriers generated responsive to incident photons from a light source, with charge carriers stored in the charge storage region(s) indicative of spectral and timing information. In some embodiments, a pixel may include regions having different depths, each configured to generate charge carriers responsive to incident photons. In some embodiments, a pixel may include multiple charge storage regions having different depths, and one or more of the charge storage regions may be configured to receive the incident photons and generate charge carriers therein. In some embodiments, a pixel may include an optical sorting element configured to direct at least some incident photons to one charge storage region and other incident photons to another charge storage region.

    Integrated sensor for lifetime characterization
    35.
    发明授权
    Integrated sensor for lifetime characterization 有权

    公开(公告)号：US11869917B2

    公开(公告)日：2024-01-09

    申请号：US17149574

    申请日：2021-01-14

    申请人： Quantum-Si Incorporated

    发明人： Eric A. G. Webster ,  Changhoon Choi ,  Dajiang Yang ,  Xin Wang ,  Todd Rearick ,  Kyle Preston ,  Ali Kabiri ,  Gerard Schmid

    IPC分类号： H01L27/146

    CPC分类号： H01L27/14643 ,  H01L27/14683

    摘要： Aspects of the technology described herein relate to improved semiconductor-based image sensor designs. In some embodiments, an integrated circuit may comprise a photodetection region and a drain region electrically coupled to the photodetection region, and the photodetection region may be configured to induce an intrinsic electric field in a direction from the photodetection region to the drain region(s). In some embodiments, a charge storage region and the drain region may be positioned on a same side of the photodetection region. In some embodiments, at least one drain layer may be configured to receive incident photons and/or charge carriers via the photodetection region. In some embodiments, an integrated circuit may comprise a plurality of pixels and a control circuit configured to control a transfer of charge carriers in the plurality of pixels.

    Optical and electrical secondary path rejection
    37.
    发明授权
    Optical and electrical secondary path rejection 有权

    公开(公告)号：US11804499B2

    公开(公告)日：2023-10-31

    申请号：US16913688

    申请日：2020-06-26

    申请人： Quantum-Si Incorporated

    发明人： Dajiang Yang ,  Farshid Ghasemi ,  Keith G. Fife ,  Todd Rearick ,  Ali Kabiri ,  Gerard Schmid ,  Eric A. G. Webster

    IPC分类号： H01L27/146 ,  H04N25/771

    CPC分类号： H01L27/14609 ,  H01L27/14623 ,  H01L27/14625 ,  H01L27/14636 ,  H04N25/771

    摘要： Described herein are techniques to reduce or remove the impact of secondary path photons and/or charge carriers on storage bins of an integrated device to improve noise performance, and thus, sample analysis. Some embodiments relate to optical rejection techniques such as including an optical barrier positioned to block at least some photons from reaching the storage bins. Some embodiments relate to electrical rejection techniques such as including an electrical barrier configured to block at least some charge carriers from reaching the storage bins along at least one secondary path. Some embodiments relate to an integrated device in which at least one storage bin is shaped and/or positioned relative to the photodetector to facilitate receipt of some charge carriers (e.g., fluorescent emission charge carriers) and/or photons and to impede receipt of other charge carriers (e.g., noise charge carriers) and/or photons.

    LIGHT COUPLING DEVICE
    40.
    发明申请
    LIGHT COUPLING DEVICE 有权

    公开(公告)号：US20230114694A1

    公开(公告)日：2023-04-13

    申请号：US17962376

    申请日：2022-10-07

    申请人： Quantum-Si Incorporated

    发明人： Gerard Schmid ,  Ali Kabiri ,  Seled Ali Safiabadi Tali

    IPC分类号： G01N21/64 ,  G01N21/45

    摘要： An integrated device, comprising a substrate having a first surface; and at least one pixel formed on or in the substrate. The at least one pixel comprising a reaction chamber configured to receive a sample, and a sensor configured to detect emission light emitted from the reaction chamber and at least one nanostructure disposed in a plane between a waveguide and the sensor, wherein the optical nanostructure is configured to converge at least a portion of the emission light in a direction substantially perpendicular to the plane. The waveguide is configured to couple excitation light to each pixel.