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53 条记录 (耗时 0.035 秒)

    Buoy Suspension Fractionation System
    31.
    发明申请
    Buoy Suspension Fractionation System 有权
    浮标分离系统

    公开(公告)号：US20110021334A1

    公开(公告)日：2011-01-27

    申请号：US12897401

    申请日：2010-10-04

    申请人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    发明人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    IPC分类号： B01D21/26

    CPC分类号： B01D21/262 ,  A61M1/029 ,  A61M1/3693 ,  B01D21/26 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0409 ,  G01N33/491

    摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

    摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

    Methods and apparatus for isolating platelets from blood
    32.
    发明授权
    Methods and apparatus for isolating platelets from blood 有权
    从血液中分离血小板的方法和装置

    公开(公告)号：US07470371B2

    公开(公告)日：2008-12-30

    申请号：US11584414

    申请日：2006-10-19

    申请人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    IPC分类号： C02F1/38 ,  B04B1/04 ,  B04B1/06 ,  B04B3/02 ,  B04B1/00

    CPC分类号： A61M1/3693 ,  A61K35/00 ,  A61M2202/0427 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0633 ,  G01N33/49 ,  Y10T436/25375

    摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

    摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 然后从血小板收集表面除去血小板。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。

    APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF
    33.
    发明申请
    APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF 有权
    制备稀土等离子体及其浓度的装置和方法

    公开(公告)号：US20080011684A1

    公开(公告)日：2008-01-17

    申请号：US11831605

    申请日：2007-07-31

    申请人： Randel Dorian ,  Michael Leach

    发明人： Randel Dorian ,  Michael Leach

    IPC分类号： B01D35/00 ,  B01D24/32 ,  B01D33/067

    CPC分类号： A61M1/3496 ,  A61M1/3482 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  B04B5/0442 ,  B04B2005/0478

    摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.

    摘要翻译： 公开了一种富血小板血浆分离器组件。 组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。 底板，其具有向下倾斜到中心开口的上表面。 内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。 内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。 圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。

    Method and apparatus for preparing platelet rich plasma and concentrates thereof
    37.
    发明授权
    Method and apparatus for preparing platelet rich plasma and concentrates thereof 失效
    制备富血小板血浆及其浓缩物的方法和装置

    公开(公告)号：US08133389B2

    公开(公告)日：2012-03-13

    申请号：US13193849

    申请日：2011-07-29

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： A61M1/16 ,  A61M1/18 ,  B04B7/08 ,  B01D21/26 ,  B01D61/20 ,  B01D61/22 ,  B01D63/02

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。

    Methods and Apparatus for Isolating Platelets From Blood
    39.
    发明申请
    Methods and Apparatus for Isolating Platelets From Blood 有权
    血液分离血小板的方法与装置

    公开(公告)号：US20110065183A1

    公开(公告)日：2011-03-17

    申请号：US12951701

    申请日：2010-11-22

    申请人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    IPC分类号： C12N5/078

    CPC分类号： A61M1/3693 ,  A61K35/00 ,  A61M2202/0427 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0633 ,  G01N33/49 ,  Y10T436/25375

    摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

    摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。

    Plasma Concentrator Device
    40.
    发明申请
    Plasma Concentrator Device 有权
    等离子集中器

    公开(公告)号：US20090236297A1

    公开(公告)日：2009-09-24

    申请号：US12476838

    申请日：2009-06-02

    申请人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Michael D. Leach ,  Richard Wood Storrs

    IPC分类号： B01D33/27

    CPC分类号： A61M1/3679 ,  A61M1/0204 ,  A61M1/3693 ,  A61M2202/0415 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

    摘要翻译： 具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。