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公开(公告)号：US20140256024A1
公开(公告)日：2014-09-11
申请号：US14285354
申请日：2014-05-22
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , Karen Espina , George Rudenko , Penelope Chua
IPC: C12N9/24
CPC classification number: C12P7/6427 , C07C1/2078 , C07K2319/01 , C10L1/02 , C12N9/00 , C12N9/16 , C12N9/2402 , C12N15/79 , C12P7/20 , C12P7/64 , C12P7/6409 , C12P7/6418 , C12P7/6463 , C12P7/649 , C12Y301/02014 , C12Y302/01026 , Y02E50/13 , Y02P20/52 , Y02P60/877 , Y02T50/678
Abstract: Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to be cultivated on sugar cane and sugar beets as a feedstock. In some embodiments, the vectors are useful for the purpose of performing targeted modifications to the nuclear genome of heterotrophic microalgae.
Abstract translation: 公开了来自微藻的新型基因序列，以及可用于制备甘油三酯油的新型基因序列。 还公开了允许将微藻种植在甘蔗和甜菜作为原料的序列和载体。 在一些实施方案中，载体可用于进行对异养微藻的核基因组的靶向修饰。
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公开(公告)号：US20140170184A1
公开(公告)日：2014-06-19
申请号：US14015921
申请日：2013-08-30
Applicant: Solazyme, Inc.
Inventor： Geoffrey Brooks , Scott Franklin
CPC classification number: A61K8/99 , A61K8/498 , A61K8/922 , A61K8/9706 , A61K2800/10 , A61K2800/805 , A61Q1/06 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C12N1/12 , C12R1/89
Abstract: The invention provides cosmetic compositions comprising microalgal biomass, whole microalgal cells, and/or microalgal oil in combination with one or more other cosmetic ingredients, and methods of making such compositions. In preferred embodiments, the microalgal components of the cosmetic compositions are derived from microalgal cultures grown heterotrophically and which comprise at least 10% oil by dry weight.
Abstract translation: 本发明提供包含与一种或多种其它化妆品组分组合的微藻生物质，全部微藻细胞和/或微藻油的化妆品组合物，以及制备这种组合物的方法。 在优选的实施方案中，化妆品组合物的微藻组分衍生自异养生长并由干重至少10％的油生长的微藻培养基。
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公开(公告)号：US20130323823A1
公开(公告)日：2013-12-05
申请号：US13941353
申请日：2013-07-12
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC: C12P7/64
CPC classification number: C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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公开(公告)号：US20160120795A1
公开(公告)日：2016-05-05
申请号：US14931517
申请日：2015-11-03
Applicant: Solazyme, Inc.
Inventor： Geoffrey Brooks , Scott Franklin
CPC classification number: A61K8/99 , A61K8/498 , A61K8/922 , A61K8/9706 , A61K2800/10 , A61K2800/805 , A61Q1/06 , A61Q5/02 , A61Q5/12 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C12N1/12 , C12R1/89
Abstract: The invention provides cosmetic compositions comprising microalgal biomass, whole microalgal cells, and/or microalgal oil in combination with one or more other cosmetic ingredients, and methods of making such compositions. In preferred embodiments, the microalgal components of the cosmetic compositions are derived from microalgal cultures grown heterotrophically and which comprise at least 10% oil by dry weight.
Abstract translation: 本发明提供包含与一种或多种其它化妆品组分组合的微藻生物质，全部微藻细胞和/或微藻油的化妆品组合物，以及制备这种组合物的方法。 在优选的实施方案中，化妆品组合物的微藻组分衍生自异养生长并由干重至少10％的油生长的微藻培养基。
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公开(公告)号：US09249441B2
公开(公告)日：2016-02-02
申请号：US14474244
申请日：2014-09-01
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC: C12N1/20 , C12P33/00 , C12P7/64 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/00 , C07C57/03 , C07J9/00 , C12N15/82 , A23D9/013 , C11B1/00 , C12R1/89
CPC classification number: C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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Patent Agency Ranking
公开(公告)号：US20160010066A1
公开(公告)日：2016-01-14
申请号：US14796406
申请日：2015-07-10
Applicant: Solazyme, Inc.
Inventor： David Davis , George Rudenko , Aravind Somanchi , Jason Casolari , Scott Franklin , Aren Ewing
CPC classification number: C12N9/1029 , C12N15/82 , C12P7/64 , C12P7/6463 , C12P33/00 , C12Y203/01041
Abstract: The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed.
Abstract translation: 本发明涉及KASI / KASIV型的β-酮酸酰基ACP合酶基因和由这些基因编码的蛋白质。 这些基因可以包含在核酸构建体，载体或宿主细胞中。 基因产物的表达可以改变宿主细胞的脂肪酸分布。 可以将KAS基因与FATA或FATB硫酯酶基因组合以产生产生增加量的C 8 -C 16脂肪酸的细胞。 合适的宿主细胞包括植物或微藻的质体细胞。 公开了具有新基因的油性微藻宿主细胞。
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公开(公告)号：US09200307B2
公开(公告)日：2015-12-01
申请号：US13941342
申请日：2013-07-12
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC: C12P7/64 , C12N9/88 , C12P33/00 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/00 , C07C57/03 , C07J9/00 , C12N15/82 , A23D9/013 , C11B1/00 , C12R1/89
CPC classification number: C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsatturated-saturated type.
Abstract translation: 重组DNA技术用于产生产生具有所需脂肪酸谱和区域特异性或立体特异性谱的甘油三酯油的含油重组细胞。 基因操作包括编码硬脂酰-ACP脱氧酶，δ12脂肪酸去饱和酶，酰基-ACP硫酯酶，酮酰基-ACP合成酶和溶血磷脂酰基转移酶的那些。 所生产的油可以具有增强的氧化或热稳定性，或可用作煎炸油，起酥油，卷入起酥油，回火脂肪，可可脂替代物，润滑剂或用作各种化学方法的原料。 脂肪酸分布可以富集于中链轮廓，或者油可以富集饱和不饱和饱和型甘油三酸酯。
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公开(公告)号：US09115332B2
公开(公告)日：2015-08-25
申请号：US14055763
申请日：2013-10-16
Applicant: Solazyme, Inc.
Inventor： Harrison F. Dillon , Dan Elefant , Anthony G. Day , Scott Franklin , Jon Wittenberg
CPC classification number: C11B1/10 , C10L1/026 , C11B1/106 , C11C3/003 , C11C3/04 , C12P7/6463 , C12P7/649 , Y02E50/13 , Y02T50/678
Abstract: The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as biodiesel, renewable diesel, jet fuel, and other materials.
Abstract translation: 本发明一般涉及微生物中烃类组合物如脂质的生产。 特别地，本发明提供从微生物中提取，回收，分离和获得脂质以及包含脂质的组合物的方法。 本发明还公开了用于生产用作生物柴油，可再生柴油，喷气燃料和其它材料的烃组合物的方法。
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公开(公告)号：US09102973B2
公开(公告)日：2015-08-11
申请号：US13941357
申请日：2013-07-12
Applicant: Solazyme, Inc.
Inventor： Scott Franklin , Aravind Somanchi , George Rudenko , Riyaz Bhat , Xinhua Zhao , Risha Bond , Walter Rakitsky , Alejandro Marangoni , Diza Braksmayer
IPC: C12P7/64 , C12N1/11 , C12R1/89 , C12P33/00 , C12N9/02 , C12N9/10 , C12N9/16 , A23D9/00 , C07C57/03 , C07J9/00 , C12N15/82
CPC classification number: C12P7/6409 , A23D9/00 , A23D9/013 , C07C57/03 , C07J9/00 , C11B1/00 , C12N9/0071 , C12N9/1029 , C12N9/16 , C12N9/2402 , C12N15/113 , C12N15/8247 , C12N2310/531 , C12P7/64 , C12P7/6445 , C12P7/6463 , C12P7/6472 , C12P33/00 , C12R1/89 , C12Y203/01015 , C12Y203/0102 , C12Y203/01041 , C12Y203/01051 , C12Y203/01179 , C12Y203/0118 , C12Y302/01014 , C12Y302/01026 , Y02E50/13 , Y02P20/52
Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
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40.发明申请公开(公告)号：US20140336100A1
公开(公告)日：2014-11-13
申请号：US14338227
申请日：2014-07-22
Applicant: Solazyme, Inc.
Inventor： Anthony G. Day , Geoffrey Brooks , Scott Franklin
CPC classification number: C11B3/02 , A23D7/00 , A23D9/00 , C11D9/26 , C12P7/6418 , C12P7/6463 , C12P7/649 , Y02E50/13
Abstract: Chemically modified lipids and methods for their preparation are provided.
Abstract translation: 提供化学修饰的脂质及其制备方法。
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