公开(公告)号：US09053914B2

公开(公告)日：2015-06-09

申请号：US14123548

申请日：2012-06-01

Applicant: Steven Derek Pringle ,  Michael Raymond Morris ,  Stephen Smith ,  Michael McCullagh

Inventor： Steven Derek Pringle ,  Michael Raymond Morris ,  Stephen Smith ,  Michael McCullagh

IPC: H01J49/00 ,  B01D59/44 ,  H01J40/04 ,  H01J49/06 ,  H01J49/04 ,  A61B17/32 ,  A61B17/3203 ,  A61B18/00 ,  A61B18/14 ,  A61B18/18

CPC classification number: H01J49/16 ,  A61B17/320068 ,  A61B17/3203 ,  A61B18/14 ,  A61B2018/00994 ,  A61B2018/1412 ,  A61B2018/1807 ,  A61B2218/008 ,  H01J49/0022 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0459 ,  H01J49/049 ,  H01J49/06 ,  H01J49/10

Abstract: A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analyzed by contacting the substrate with a diathermy knife. An electric current is applied to the diathermy knife such that the diathermy knife vaporizes a portion of the substrate. The vapor is aspirated via a sampling tube pumped by a venturi pump into a vacuum chamber of a mass spectrometer. Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionized to form analyte ions which are then mass analyzed.

Abstract translation: 公开了一种通过质谱法检测底物中的一种或多种化合物，化学物质或污染物的方法。 通过使基材与透热刀接触来分析非活性基材。 将电流施加到透热刀，使得透热刀蒸发基底的一部分。 通过由文丘里泵泵送到质谱仪的真空室中的取样管将蒸气吸入。 分析物分子被抽吸到真空室中，因此它们影响真空室的表面，并被离子化以形成分析物离子，然后进行质量分析。

公开(公告)号：US20140306103A1

公开(公告)日：2014-10-16

申请号：US14123566

申请日：2012-06-01

Applicant: David Gordon ,  Daniel James Kenny ,  Steven Derek Pringle

Inventor： David Gordon ,  Daniel James Kenny ,  Steven Derek Pringle

IPC: H01J49/04

CPC classification number: H01J49/04 ,  H01J49/067 ,  H01J49/24

Abstract: An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets.

Abstract translation: 公开了一种用于质谱仪的离子入口，其包括具有采样孔和大气压力孔的壳体。 一个或多个气体出口设置在壳体中。 通过泵将气体抽吸通过采样孔，使得气体经由一个或多个气体出口排出。

公开(公告)号：US08809767B2

公开(公告)日：2014-08-19

申请号：US12302168

申请日：2007-06-01

Applicant: Robert Harold Bateman ,  Jeffery Mark Brown ,  Martin Green ,  Jason Lee Wildgoose ,  Anthony James Gilbert ,  Steven Derek Pringle

Inventor： Robert Harold Bateman ,  Jeffery Mark Brown ,  Martin Green ,  Jason Lee Wildgoose ,  Anthony James Gilbert ,  Steven Derek Pringle

IPC: H01J49/26 ,  H01J49/00 ,  G06K9/00

CPC classification number: H01J49/0036 ,  G06K9/0053

Abstract: A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.

Abstract translation: 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

公开(公告)号：US08633435B2

公开(公告)日：2014-01-21

申请号：US12445774

申请日：2007-10-16

Applicant: Daniel James Kenny ,  Robert Harold Bateman ,  Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle

Inventor： Daniel James Kenny ,  Robert Harold Bateman ,  Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/065 ,  H01J49/34 ,  H01J49/4235

Abstract: A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimized by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimized by the second different RF voltage applied to the downstream group of electrodes.

Abstract translation: 公开了包括多个电极的碰撞或分裂单元，其中将第一RF电压施加到上游电极组，并且将第二不同的RF电压施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池的母体离子的径向约束，并且通过第二不同RF电压优化在碰撞或断裂电池内产生的子或碎片离子的径向约束 应用于下游电极组。

公开(公告)号：US08299422B2

公开(公告)日：2012-10-30

申请号：US12917720

申请日：2010-11-02

Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason L. Wildgoose

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason L. Wildgoose

IPC: H01J49/40 ,  H01J49/42

CPC classification number: G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/02 ,  H01J49/062 ,  H01J49/065 ,  H01J49/066 ,  H01J49/40 ,  H01J49/401 ,  H01J49/42

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.

Abstract translation: 公开了一种质谱仪，其包括离子迁移谱仪或分离器，以及布置在离子迁移谱仪或分离器下游的离子导向器。 在离子导向器中产生多个轴向势阱，使得从离子迁移谱仪或分离器接收的离子变得限制在单独的轴向势阱中。 潜在的孔保持从离子迁移谱仪或分离器接收的离子的保真度和/或组成。 势阱沿离子导向器的长度平移。

公开(公告)号：US20110180704A1

公开(公告)日：2011-07-28

申请号：US13078198

申请日：2011-04-01

Applicant: Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

Inventor： Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

IPC: H01J49/28 ,  H01J3/26

CPC classification number: H01J49/065 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/36 ,  H01J49/4235 ,  Y10T436/24

Abstract: An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio.

Abstract translation: 公开了一种离子导向器或质量分析器，其包括具有孔的多个电极，在使用中离子传播通过该孔。 在离子导向器或质量分析器的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态直流电压被施加到离子导向器或质量分析器的电极，以沿着离子导向器或质量分析器的长度推动离子。 施加到电极的瞬态直流电压的幅度可以随时间增加，使得离子从离子导向器或质量分析器以其质荷比的相反顺序被发射。

公开(公告)号：US20100294923A1

公开(公告)日：2010-11-25

申请号：US12445774

申请日：2007-10-16

Applicant: Daniel James Kenny ,  Robert Harold Bateman ,  Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle

Inventor： Daniel James Kenny ,  Robert Harold Bateman ,  Martin Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle

IPC: H01J49/26 ,  H01J49/06

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/065 ,  H01J49/34 ,  H01J49/4235

Abstract: A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.

Abstract translation: 公开了一种碰撞或分裂单元（4），其包括多个电极，其中将第一RF电压（7a）施加到上游电极组，并且将第二不同RF电压（7b）施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池（4）的母体离子的径向约束，并且优化在碰撞或断裂电池（4）内产生的子或碎片离子的径向约束 通过施加到下游组电极的第二不同RF电压。

公开(公告)号：US20100213361A1

公开(公告)日：2010-08-26

申请号：US12601094

申请日：2008-05-22

Applicant: Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Martin Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/26 ,  G12B13/00

CPC classification number: H01J49/0036 ,  H01J49/40

Abstract: A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.

Abstract translation: 公开了一种质谱仪，其中离子信号被分成第一和第二信号。 第一和第二信号乘以不同的增益并被数字化。 对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。 然后将光谱与其他对应的光谱组合以形成相加光谱。

公开(公告)号：US20100108879A1

公开(公告)日：2010-05-06

申请号：US12514972

申请日：2007-11-15

Applicant: Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/26

CPC classification number: H01J49/4215 ,  G01N27/622 ,  H01J49/004 ,  H01J49/426

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).

Abstract translation: 公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。 碰撞室（10）布置在离子门（9）的下游。 离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。

公开(公告)号：US20100084547A1

公开(公告)日：2010-04-08

申请号：US12524378

申请日：2008-01-25

Applicant: Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/428

Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.

Abstract translation: 公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。 具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。 缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。 所得到的离子信号被去卷积以提供质谱。