公开(公告)号：US6077692A

公开(公告)日：2000-06-20

申请号：US23082

申请日：1998-02-13

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N15/63

CPC分类号： C07H21/00 ,  C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US07232667B2

公开(公告)日：2007-06-19

申请号：US10733311

申请日：2003-12-12

申请人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

发明人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C07K14/50

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US06693077B1

公开(公告)日：2004-02-17

申请号：US09610651

申请日：2000-06-30

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K3818

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US20080194481A1

公开(公告)日：2008-08-14

申请号：US11932823

申请日：2007-10-31

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P9/00 ,  A61P1/00 ,  A61P25/00 ,  C12N1/00 ,  C12N1/20 ,  C12P21/04

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20110002888A1

公开(公告)日：2011-01-06

申请号：US12793658

申请日：2010-06-03

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/21 ,  C07K14/76 ,  A61K38/38 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  A61K38/46 ,  A61K38/18 ,  A61K38/22 ,  A61K39/395 ,  A61K38/43 ,  C12N9/96 ,  A61K39/12 ,  A61K38/30 ,  A61P35/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P37/02 ,  A61P9/08 ,  A61P9/00 ,  A61P9/04 ,  A61P1/16 ,  A61P25/30 ,  A61P31/12 ,  A61P9/12

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US06433145B1

公开(公告)日：2002-08-13

申请号：US09487792

申请日：2000-01-20

申请人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

发明人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

IPC分类号： C07K1700

CPC分类号： C07K14/555 ,  A61K38/00 ,  C10M2209/108 ,  C10M2209/109

摘要： The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及作为干扰素家族成员的新型KDI蛋白。 特别地，提供编码人干扰素多肽的分离的核酸分子，称为“KDI”。 还提供KDI多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定KDI活性的激动剂和拮抗剂的筛选方法。 还提供了治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US07390637B2

公开(公告)日：2008-06-24

申请号：US10197816

申请日：2002-09-12

申请人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

发明人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

IPC分类号： C12N15/20 ,  C12N15/00 ,  C12P21/06 ,  C07H21/04

CPC分类号： C07K14/555 ,  A61K38/00 ,  C10M2209/108 ,  C10M2209/109

摘要： The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及作为干扰素家族成员的新型KDI蛋白。 特别地，提供编码人干扰素多肽的分离的核酸分子，称为“KDI”。 还提供KDI多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定KDI活性的激动剂和拮抗剂的筛选方法。 还提供了治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06472512B1

公开(公告)日：2002-10-29

申请号：US09908594

申请日：2001-07-20

申请人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

发明人： David W. LaFleur ,  Paul A. Moore ,  Steven M. Ruben

IPC分类号： C07K1600

CPC分类号： C07K14/555 ,  A61K38/00 ,  C10M2209/108 ,  C10M2209/109

摘要： The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.

公开(公告)号：US08143026B2

公开(公告)日：2012-03-27

申请号：US12534585

申请日：2009-08-03

申请人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben ,  Paul A. Moore ,  Jason B. Bock ,  David LaFleur

发明人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben ,  Paul A. Moore ,  Jason B. Bock ,  David LaFleur

IPC分类号： C12N15/62 ,  C12N15/81 ,  C12N15/85 ,  C12N15/14 ,  C12N15/16

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

公开(公告)号：US07816091B2

公开(公告)日：2010-10-19

申请号：US12358097

申请日：2009-01-22

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore

IPC分类号： G01N33/53 ,  C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7155

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.

摘要翻译： 本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。 更具体地，本发明涉及编码称为细胞因子受体通用γ链或类似于“CRCGCL”的新型人多肽的多核苷酸。本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体， 及其制备方法。 还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。 本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。