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48 条记录 (耗时 0.059 秒)

    Amidine derivatives for treating amyloidosis
    31.
    发明申请
    Amidine derivatives for treating amyloidosis 审中-公开
    用于治疗淀粉样变性的脒衍生物

    公开(公告)号：US20070021483A1

    公开(公告)日：2007-01-25

    申请号：US11335171

    申请日：2006-01-19

    申请人： Robert Chalifour ,  Xianqi Kong ,  Xinfu Wu ,  Wenshuo Lu

    发明人： Robert Chalifour ,  Xianqi Kong ,  Xinfu Wu ,  Wenshuo Lu

    IPC分类号： A61K31/4184 ,  A61K31/155 ,  C07D403/02 ,  C07C257/12

    CPC分类号： C07C257/18 ,  A61K31/155 ,  A61K31/341 ,  A61K31/343 ,  A61K31/4164 ,  A61K31/4184 ,  Y02P20/582

    摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

    摘要翻译： 本发明涉及脒化合物在淀粉样蛋白相关疾病的治疗中的应用。 特别地，本发明涉及治疗或预防受试者中淀粉样蛋白相关疾病的方法，其包括向受试者施用治疗量的脒化合物。 根据本发明使用的化合物是根据下式的那些，使得当给药时，降低或抑制淀粉样蛋白原纤维形成，神经变性或细胞毒性：

    Pharmaceutical drug candidates and methods for preparation thereof
    33.
    发明申请
    Pharmaceutical drug candidates and methods for preparation thereof 有权
    药物候选药物及其制备方法

    公开(公告)号：US20050143462A1

    公开(公告)日：2005-06-30

    申请号：US10871543

    申请日：2004-06-18

    申请人： Xianqi Kong ,  David Migneault ,  Xinfu Wu

    发明人： Xianqi Kong ,  David Migneault ,  Xinfu Wu

    IPC分类号： A61K31/185

    CPC分类号： A61K31/185

    摘要： The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.

    摘要翻译： 本发明涉及制备磺酸衍生化合物的方法，例如3-氨基-1-丙磺酸和1,3-丙烷二磺酸二钠盐，其纯度提高，有毒副产物的潜力降低，且为药学上 有用的，例如用于治疗淀粉样变性。

    Phosphono-carboxylate compounds for treating amyloidosis
    35.
    发明授权
    Phosphono-carboxylate compounds for treating amyloidosis 失效

    公开(公告)号：US06329356B1

    公开(公告)日：2001-12-11

    申请号：US09288583

    申请日：1999-04-08

    申请人： Walter A. Szarek ,  Xianqi Kong

    发明人： Walter A. Szarek ,  Xianqi Kong

    IPC分类号： A61K3166

    CPC分类号： A61K31/662 ,  A61K31/66 ,  A61K31/675

    摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

    Phosphonocarboxylate compounds for treating amyloidosis
    36.
    发明授权
    Phosphonocarboxylate compounds for treating amyloidosis 失效
    用于治疗淀粉样变性的膦酰化物化合物

    公开(公告)号：US5869469A

    公开(公告)日：1999-02-09

    申请号：US912574

    申请日：1997-08-18

    申请人： Walter A. Szarek ,  Xianqi Kong

    发明人： Walter A. Szarek ,  Xianqi Kong

    IPC分类号： A61K31/675 ,  C07F9/40 ,  A61K31/66

    CPC分类号： A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  C07F9/4065

    摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

    摘要翻译： 描述了治疗化合物和调节受试者淀粉样蛋白沉积的方法，无论其临床情况如何。 通过给予受试者调节淀粉样蛋白沉积，所述有效量的包含膦酸酯基和羧酸酯基的治疗化合物或其药学上可接受的盐或酯。 在优选的实施方案中，调节淀粉样蛋白形成蛋白质与基底膜成分之间的相互作用。