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公开(公告)号：US20160137711A1
公开(公告)日：2016-05-19
申请号：US14343111
申请日：2012-09-12
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-Wei Wang , Nathan Geething , Benjamin Spink
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A61K38/00 , C07K2319/31
摘要： The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of GLP-2-related conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的GLP-2蛋白或其变体的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗 GLP-2相关条件。
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公开(公告)号：US08492530B2
公开(公告)日：2013-07-23
申请号：US12939120
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US08088609B2
公开(公告)日：2012-01-03
申请号：US10590870
申请日：2005-04-12
IPC分类号： C07K16/00
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译： 本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。
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34.发明授权Mutant E. coli appa phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same 有权突变大肠杆菌植酸酶及其天然变体，编码这种植酸酶的核酸，与其结合的载体和宿主细胞以及制备和使用它们的方法公开(公告)号：US07968342B2
公开(公告)日：2011-06-28
申请号：US10524234
申请日：2003-08-11
申请人： Beat O Blattmann , Aldis Darzins , John M. Davis , Lance P. Encell , Thomas B. Morrison , Gregory T. Mrachko , Volker Schellenberger
发明人： Beat O Blattmann , Aldis Darzins , John M. Davis , Lance P. Encell , Thomas B. Morrison , Gregory T. Mrachko , Volker Schellenberger
CPC分类号： C12N15/8243 , C12N9/16 , C12N15/8245
摘要： Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.
摘要翻译： 提供具有改变活性的产生突变体植酸酶的细胞，以及如此制备的植酸酶。 还提供了制备和生产这种植酸酶的方法以及在饲料中使用表达的植酸酶蛋白作为补充物。
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35.发明申请METHODS FOR PRODUCTION OF UNSTRUCTURED RECOMBINANT POLYMERS AND USES THEREOF 审中-公开生产未经改造的重组聚合物的方法及其用途公开(公告)号：US20110151433A1
公开(公告)日：2011-06-23
申请号：US12939129
申请日：2010-11-03
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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36.发明申请公开(公告)号：US20110046060A1
公开(公告)日：2011-02-24
申请号：US12806004
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US07125695B2
公开(公告)日：2006-10-24
申请号：US10719571
申请日：2003-11-20
CPC分类号： C12N9/0006 , C07K14/245 , C12N15/102 , C12P7/18 , C12R1/01 , C12R1/19
摘要： The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.
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公开(公告)号：US07122334B2
公开(公告)日：2006-10-17
申请号：US10899751
申请日：2004-07-26
申请人： Volker Schellenberger , Donald P. Naki , Katherine D. Collier , James T. Kellis, Jr. , Joanne Nadherny
发明人： Volker Schellenberger , Donald P. Naki , Katherine D. Collier , James T. Kellis, Jr. , Joanne Nadherny
IPC分类号： C12Q1/34
CPC分类号： C12Q1/00
摘要： A microtiter method for assaying the wash performance of new enzymes and/or new detergent formulations is described.
摘要翻译： 描述了用于测定新酶和/或新洗涤剂制剂的洗涤性能的微量滴定法。
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公开(公告)号：US20060183171A1
公开(公告)日：2006-08-17
申请号：US11378735
申请日：2006-03-17
申请人： Volker Schellenberger , Amy Liu
发明人： Volker Schellenberger , Amy Liu
IPC分类号： G01N33/53
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00319 , B01J2219/0052 , B01J2219/00524 , B01J2219/00533 , B01J2219/00596 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01L3/5025 , B01L3/5085 , B01L3/50857 , B01L2300/0654 , B01L2300/0809 , B01L2300/161 , C40B60/14 , G01N35/1065 , G01N2035/00237
摘要： A high throughput screening method. At least one liquid sample is provided that includes an analyte that directly or indirectly produces a detectable characteristic in one or more first assays. A plurality of through holes is filled with portions of the liquid sample in a testing assembly that has a pair of opposing surfaces, each through hole extending from one of the opposing surfaces to the other of the opposing surfaces, with the through holes arranged in group. Surface tension holds the respective portions in the respective plurality of through holes. A detection is made of which of the through holes contains a liquid sample portion that includes said analyte. The detectable characteristic may be produced in various assays such as an absorbance transcription assay, a fluorescent transcription assay, a fluorescent secreted enzyme assay, or a microorganism screening assay.
摘要翻译： 高通量筛选方法。 提供至少一种液体样品，其包括在一个或多个第一测定中直接或间接产生可检测特征的分析物。 多个通孔在具有一对相对表面的测试组件中填充有液体样品的部分，每个通孔从相对表面中的一个延伸到另一个相对表面，通孔布置成 。 表面张力保持相应的多个通孔中的各个部分。 检测哪个通孔包含包含所述分析物的液体样品部分。 可以在各种测定中产生可检测特征，例如吸光度转录测定，荧光转录测定，荧光分泌酶测定或微生物筛选测定。
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40.发明申请Mutant E. coli appa phytase enzymes and natural variants thereof, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same 有权突变大肠杆菌植酸酶及其天然变体，编码这种植酸酶的核酸，与其结合的载体和宿主细胞以及制备和使用它们的方法公开(公告)号：US20060141562A1
公开(公告)日：2006-06-29
申请号：US10524234
申请日：2003-08-11
申请人： Beat Blattmann , Aldis Darzins , John Davis , Lance Encell , Thomas Morrison , Gregory Mrachko , Volker Schellenberger
发明人： Beat Blattmann , Aldis Darzins , John Davis , Lance Encell , Thomas Morrison , Gregory Mrachko , Volker Schellenberger
CPC分类号： C12N15/8243 , C12N9/16 , C12N15/8245
摘要： Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.
摘要翻译： 提供具有改变活性的产生突变体植酸酶的细胞，以及如此制备的植酸酶。 还提供了制备和生产这种植酸酶的方法以及在饲料中使用表达的植酸酶蛋白作为补充物。
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