公开(公告)号：US06635684B2

公开(公告)日：2003-10-21

申请号：US10083242

申请日：2001-10-19

申请人： Huey-Min Lai ,  Chun-Hui Chang ,  Chun-Jen Liao ,  Chin-Fu Chen ,  Kuei-Hung Wu ,  Yuan-Chia Chang ,  Yu-Yen Jan ,  Tsung-Yi Mou

发明人： Huey-Min Lai ,  Chun-Hui Chang ,  Chun-Jen Liao ,  Chin-Fu Chen ,  Kuei-Hung Wu ,  Yuan-Chia Chang ,  Yu-Yen Jan ,  Tsung-Yi Mou

IPC分类号： C08J900

CPC分类号： C08L5/08 ,  C07K17/08 ,  C08B37/003 ,  C08H1/06 ,  C08J9/26 ,  C08J2201/0462 ,  C08L89/06 ,  C08L2666/02

摘要： The present invention discloses a method for preparing a hydrophilic porous polymeric material comprising the step of mixing a hydrophilic polymeric material with a hydrophobic material; solvent sintering the surface of the hydrophilic polymeric material with water or an aqueous solution; and removing the hydrophobic material contained within the hydrophilic polymeric material with a massive organic solvent. Thus, the hydrophilic porous polymeric material with high porosity and stable structure is rapidly mass produced.

公开(公告)号：US20130172946A1

公开(公告)日：2013-07-04

申请号：US13565822

申请日：2012-08-03

申请人： Ching-Chuan Jiang ,  Chun-Jen Liao ,  Wen-Hsiang Chang ,  Shih-Jui Han ,  Yu-Ming Wang ,  Ying-Wen Shen

发明人： Ching-Chuan Jiang ,  Chun-Jen Liao ,  Wen-Hsiang Chang ,  Shih-Jui Han ,  Yu-Ming Wang ,  Ying-Wen Shen

IPC分类号： A61B17/86 ,  A61B17/88

CPC分类号： A61B17/1764 ,  A61B17/68 ,  A61B17/683

摘要： An implant module for dragging a bone fragment toward a bone is provided. The bone fragment has a first through hole, and the bone has a second through hole. The implant module includes a screw and a stud. The screw has a first section fixed to the bone fragment and a second section provided with a first external thread on its outer surface. The stud is provided with a second external thread on its outer surface for being screwed into the second through hole of the bone. An end of the stud has a screw hole for being screwed with the second section of the screw via the first external thread. A method of repairing avulsion fracture by using the implant module is further provided.

摘要翻译： 提供了一种用于将骨碎片拖向骨骼的植入物模块。 骨碎片具有第一通孔，骨骼具有第二通孔。 植入模块包括螺钉和螺栓。 螺钉具有固定到骨碎片的第一部分和在其外表面上设置有第一外螺纹的第二部分。 螺柱在其外表面上设置有第二外螺纹，用于螺纹连接到骨的第二通孔中。 螺柱的端部具有螺纹孔，用于经由第一外螺纹与螺钉的第二部分螺纹连接。 还提供了通过使用植入模块来修复撕脱破裂的方法。

公开(公告)号：US08435271B2

公开(公告)日：2013-05-07

申请号：US13231924

申请日：2011-09-13

申请人： Ching-Chuan Jiang ,  Shan-Chang Chueh ,  Ting-Hui Chiu ,  Chun-Jen Liao ,  Yi-Hung Lin ,  Ya-Jen Yu ,  I-Fan Chiu

发明人： Ching-Chuan Jiang ,  Shan-Chang Chueh ,  Ting-Hui Chiu ,  Chun-Jen Liao ,  Yi-Hung Lin ,  Ya-Jen Yu ,  I-Fan Chiu

IPC分类号： A61B17/03

CPC分类号： A61F2/0811 ,  A61B17/8875 ,  A61F2/0805 ,  A61F2002/0829 ,  A61F2002/0835 ,  A61F2002/0858 ,  A61F2002/0888

摘要： A device for fixing soft tissue. A sleeve is detachably connected to a self-drilling tapping screw, moving and rotating the self-drilling tapping screw. A guide bar is detachably connected to the self-drilling tapping screw and fit in the sleeve. A fixing pin is fit in a washer and connected to the self-drilling tapping screw. The guide bar is detachably fit in the fixing pin. The fixing pin abuts the washer and the self-drilling tapping screw.

摘要翻译： 用于固定软组织的装置。 套筒可拆卸地连接到自钻自攻螺钉，移动和旋转自钻自攻螺钉。 引导杆可拆卸地连接到自钻自攻螺钉并且装配在套筒中。 固定销安装在垫圈中，并与自钻自攻螺钉相连。 导杆可拆卸地安装在固定销中。 固定销与垫圈和自钻自攻螺钉相接。

公开(公告)号：US07906333B2

公开(公告)日：2011-03-15

申请号：US11384386

申请日：2006-03-21

申请人： Chun-Jen Liao ,  Yung-chih Wu ,  Chen-Chi Tsai ,  Hsiang-Ming Huang ,  Yuan-Hua Hsu ,  Shu-Fang Chiang

发明人： Chun-Jen Liao ,  Yung-chih Wu ,  Chen-Chi Tsai ,  Hsiang-Ming Huang ,  Yuan-Hua Hsu ,  Shu-Fang Chiang

IPC分类号： C12N5/00 ,  A61K31/715

CPC分类号： C12N5/0068 ,  C12N2500/10 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74

摘要： A surface modification method of polysaccharide, the modified polysaccharide, and a method of culturing and recovery cells using the same are provided. The surface modification method of polysaccharide comprises (a) immersing a polysaccharide material in an acid, (b) immersing the polysaccharide material in an acidic solution containing a protein, and (c) immersing the polysaccharide material in an alkaline solution containing bivalent metal ions.

摘要翻译： 提供了多糖，改性多糖的表面改性方法，以及使用其的培养和回收细胞的方法。 多糖的表面改性方法包括（a）将多糖材料浸入酸中，（b）将多糖材料浸入含有蛋白质的酸性溶液中，（c）将多糖材料浸入含有二价金属离子的碱性溶液中。

公开(公告)号：US20090007937A1

公开(公告)日：2009-01-08

申请号：US12104685

申请日：2008-04-17

申请人： Chung-Nun Chen ,  Chun-Jen Liao ,  Chin-Yu Lin ,  Chin-Fu Chen ,  Yung-chih Wu

发明人： Chung-Nun Chen ,  Chun-Jen Liao ,  Chin-Yu Lin ,  Chin-Fu Chen ,  Yung-chih Wu

IPC分类号： B08B3/04

CPC分类号： B08B3/102 ,  B01L3/502 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0478 ,  C12M47/12

摘要： In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.

摘要翻译： 在一般方面，提供了一种用于洗涤生物材料的装置，其包括外套筒和设置在外套筒内的内套筒。 外套筒具有用于接收生物材料的开口端和相对的封闭端。 所述内套筒可拆卸地且可滑动地定位在所述外套筒内，并且包括用于接收和分配洗涤液体的第一端口，限定所述内套筒的内部和所述外套筒的内部之间的液体流路的第二端口，以及 过滤器设置在第二端口中。 过滤器允许洗涤液体通过，但不允许生物材料通过。 形成在过滤器和外套管的封闭端之间的室被构造成允许经由过滤器流动清洗液体，同时将生物材料保持在其中。

公开(公告)号：US20080026455A1

公开(公告)日：2008-01-31

申请号：US11808117

申请日：2007-06-06

申请人： Chun-Jen Liao ,  Yu-Ju Lin ,  Chin-Fu Chen ,  Ken-Yuan Chang ,  Shu-Fang Chiang

发明人： Chun-Jen Liao ,  Yu-Ju Lin ,  Chin-Fu Chen ,  Ken-Yuan Chang ,  Shu-Fang Chiang

IPC分类号： C12M3/00

CPC分类号： C12N5/0655 ,  C12N5/0062 ,  C12N2533/40

摘要： A porous chamber for tissue culture in vitro. The porous chamber includes a main body made of porous biologically absorbable polymer material, comprising an inner surface surrounding a hollow cavity, the hollow cavity having an aperture opened at an upper surface of the main body, wherein the aperture is communicated with outside of the main body for seeding tissue blocks in the hollow cavity, and an upper cover passing through the upper surface of the main body to seal the aperture to prevent the tissue blocks from outflowing.

摘要翻译： 用于组织培养的多孔室。 所述多孔室包括由多孔生物可吸收聚合物材料制成的主体，包括围绕中空腔的内表面，所述中空腔具有在所述主体的上表面处开口的孔，其中所述孔与所述主体的外部连通 在中空腔中播种组织块的主体，以及穿过主体的上表面的上盖，以密封孔以防止组织块流出。

公开(公告)号：US07151139B2

公开(公告)日：2006-12-19

申请号：US10123860

申请日：2002-04-16

申请人： Joerg C. Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander M. Klibanov

发明人： Joerg C. Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander M. Klibanov

IPC分类号： C08L67/02

CPC分类号： A61L27/50 ,  A01N43/40 ,  A61L27/34 ,  A01N25/34 ,  A01N25/10 ,  A01N2300/00 ,  C08L33/14

摘要： Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.

公开(公告)号：US20060223175A1

公开(公告)日：2006-10-05

申请号：US11176411

申请日：2005-07-07

申请人： Yu-Chen Hu ,  Huang-Chi Chen ,  Chun-Jen Liao

发明人： Yu-Chen Hu ,  Huang-Chi Chen ,  Chun-Jen Liao

IPC分类号： C12M3/00

CPC分类号： C12M35/04 ,  C12M41/12

摘要： A bioreactor for cultivating tissue cells comprises a vessel containing a gas phase and a liquid phase therein, at least a substrate on which the tissue cells are attached, and a movable shaft to which the substrate is fixed. The movable shaft carries the substrate into and out of the gas and liquid phases so as to apply shear stress to the tissue cells.

摘要翻译： 用于培养组织细胞的生物反应器包括其中包含气相和液相的容器，至少其上附着有组织细胞的基底和固定有基底的活动轴。 可移动轴将衬底进入和离开气相和液相，以向组织细胞施加剪切应力。

公开(公告)号：US06824716B2

公开(公告)日：2004-11-30

申请号：US10241440

申请日：2002-09-12

申请人： Chun-Jen Liao ,  Yu-Ju Lin ,  Chin-Fu Chen ,  Ken-Yuan Chang

发明人： Chun-Jen Liao ,  Yu-Ju Lin ,  Chin-Fu Chen ,  Ken-Yuan Chang

IPC分类号： B29C6720

CPC分类号： C08J9/26 ,  B29C67/202 ,  C08J2201/042 ,  C08J2201/044 ,  C08J2201/0464

摘要： A process for producing porous polymer material. The method combines a polymer and water-soluble granules to form a mixture. The mixture is placed into a mold; the surface of the polymer is dissolved to cause cohesion and form a polymer structure having water-soluble granules dispersed within, and water is introduced into the inner part of the polymer structure so that the polymer is solidified and water-soluble granules are washed out to obtain a porous polymer material. According to the invention, single or multiple layers of porous polymer material with different apertures, porosities, or made with different materials, are obtained by combining different polymer materials and water-soluble granules having different particle sizes in different weight ratios.

摘要翻译： 一种多孔聚合物材料的制造方法。 该方法结合聚合物和水溶性颗粒以形成混合物。 将混合物放入模具中; 溶解聚合物的表面以引起内聚，并形成分散在其中的水溶性颗粒的聚合物结构，并且将水引入聚合物结构的内部，使得聚合物固化并将水溶性颗粒冲洗至 获得多孔聚合物材料。 根据本发明，通过将不同聚合物材料和具有不同重量比的不同粒度的水溶性颗粒结合，获得具有不同孔径，孔隙率或不同材料制成的单层或多层多孔聚合物材料。

公开(公告)号：US08946305B2

公开(公告)日：2015-02-03

申请号：US13608927

申请日：2012-09-10

申请人： Chun-Jen Liao ,  Wen-Hsi Wang ,  Ming-Chia Yang ,  Wei-Ju Liao

发明人： Chun-Jen Liao ,  Wen-Hsi Wang ,  Ming-Chia Yang ,  Wei-Ju Liao

IPC分类号： C08J3/02

CPC分类号： B01J13/0039

摘要： The disclosure provides a method for crosslinking a colloid, including: (a) providing a colloid solution; (b) adding a crosslinking agent and solid particles to the colloid solution, wherein the amount of solid particles added is enough to convert the colloid solution into a solid mixture, and wherein a crosslinking reaction proceeds in the solid mixture; and (c) removing the solid particles from the solid mixture.

摘要翻译： 本公开提供了一种交联胶体的方法，包括：（a）提供胶体溶液; （b）向胶体溶液中加入交联剂和固体颗粒，其中加入的固体颗粒的量足以将胶体溶液转化为固体混合物，并且其中在固体混合物中进行交联反应; 和（c）从固体混合物中除去固体颗粒。