公开(公告)号：US12070604B2

公开(公告)日：2024-08-27

申请号：US17450308

申请日：2021-10-08

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Pepin ,  Shiv Sabesan

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

CPC classification number: A61N1/36139 ,  A61N1/0534 ,  A61N1/36007 ,  A61N1/36031 ,  A61N1/36067 ,  A61N1/36135 ,  A61N1/3614 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36062 ,  A61N1/36064 ,  A61N1/36071 ,  A61N1/36085 ,  A61N1/36096 ,  A61N1/3752

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US11878160B2

公开(公告)日：2024-01-23

申请号：US15752502

申请日：2016-08-18

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61N1/36 ,  A61B5/388 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61N1/205 ,  A61B5/087 ,  A61B5/0816 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/3611 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US11844952B2

公开(公告)日：2023-12-19

申请号：US17164350

申请日：2021-02-01

Applicant: Galvani Bioelectronics Limited

Inventor： Rizwan Bashirullah

IPC: A61N1/372 ,  A61N1/378 ,  A61N1/36 ,  A61N1/05 ,  H04B5/00 ,  A61N1/375 ,  A61B5/00

CPC classification number: A61N1/3787 ,  A61B5/0026 ,  A61B5/0031 ,  A61N1/0556 ,  A61N1/3605 ,  A61N1/375 ,  A61N1/3754 ,  A61N1/3756 ,  A61N1/37223 ,  H04B5/0081 ,  A61B2560/0219 ,  A61M2205/3538 ,  A61M2205/3569 ,  H04B5/0075

Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.

公开(公告)号：USD1001417S1

公开(公告)日：2023-10-17

申请号：US29710833

申请日：2019-10-25

Applicant: Galvani Bioelectronics Limited

Designer： Morten Hansen ,  Jay Canham

Abstract: FIG. 1 is a perspective view of a CHARGER POSITIONING BELT according to a first embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 2 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 3 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 4 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 5 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 6 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 7 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 8 is a perspective view of a CHARGER POSITIONING BELT according to a second embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 9 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 10 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 11 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 12 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 13 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 14 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 15 is a perspective view of a CHARGER POSITIONING BELT according to a third embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 16 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 17 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 18 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 19 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 20 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 21 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 22 is a perspective view of a CHARGER POSITIONING BELT according to a fourth embodiment.
FIG. 23 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 24 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 22, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 25 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 26 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 27 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 28 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 22.
FIG. 29 is a perspective view of a CHARGER POSITIONING BELT according to a fifth embodiment.
FIG. 30 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 31 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 29, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 32 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 33 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 34 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 35 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 29.
FIG. 36 is a perspective view of a CHARGER POSITIONING BELT according to a sixth embodiment.
FIG. 37 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 38 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 36, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 39 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 40 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 41 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 42 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 36.
FIG. 43 is a top view of a CHARGER POSITIONING BELT according to a seventh embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 44 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 45 is a perspective view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 46 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 47 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 46.
FIG. 48 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 49 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 43.
FIG. 50 is a perspective view of a CHARGER POSITIONING BELT according to an eighth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 51 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 52 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 53 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 54 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 55 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 56 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 50.
FIG. 57 is a perspective view of a CHARGER POSITIONING BELT according to an ninth embodiment, with unclaimed portions shown in broken line for illustrative purposes only.
FIG. 58 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 59 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 60 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 61 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 62 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 57.
FIG. 63 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 57.
The broken lines depict portions of the article that form no part of the claimed design.

公开(公告)号：USD998933S1

公开(公告)日：2023-09-19

申请号：US29710835

申请日：2019-10-25

Applicant: Galvani Bioelectronics Limited

Designer： Morten Hansen ,  Jay Canham

Abstract: FIG. 1 is a perspective view of a CHARGER POSITIONING BELT according to a first embodiment.
FIG. 2 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 3 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 4 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 5 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 6 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 7 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 1.
FIG. 8 is a perspective view of a CHARGER POSITIONING BELT according to a second embodiment.
FIG. 9 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 10 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 11 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 12 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 13 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 14 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 8.
FIG. 15 is a perspective view of a CHARGER POSITIONING BELT according to a third embodiment.
FIG. 16 is a front view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 17 is a back view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 18 is a right side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 19 is a left side view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 20 is a top view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 21 is a bottom view of the CHARGER POSITIONING BELT depicted in FIG. 15.
FIG. 22 is a rear detailed perspective partial view of an end of the CHARGER POSITIONING BELT depicted in all three of the embodiments, with the remainder of the charger positioning belt broken away and the band removed for convenience of illustration.
The broken lines depict portions of the article that form no part of the claimed design.

公开(公告)号：US11724102B2

公开(公告)日：2023-08-15

申请号：US17872829

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/378

CPC classification number: A61N1/0556 ,  A61N1/0553 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/3787

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：USD994597S1

公开(公告)日：2023-08-08

申请号：US29826951

申请日：2022-02-16

Applicant: Galvani Bioelectronics Limited

Designer： Jay Canham ,  David Lari ,  Cindy Au ,  Melissa Lara ,  Daniel Nobre ,  Ryan Jongwoo Choi

Abstract: FIG. 1 is a top perspective view of a charger;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is top plan view thereof;
FIG. 4 is a bottom plan view thereof;
FIG. 5 is a front elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a left side elevation view thereof; and,
FIG. 8 is a rear elevation view thereof.
The broken lines in the drawings are for the purpose of illustrating portions of the charger that form no part of the claimed design.

公开(公告)号：US11697026B2

公开(公告)日：2023-07-11

申请号：US15733239

申请日：2018-12-14

Applicant: Galvani Bioelectronics Limited

Inventor： Benjamin Yaffe ,  Kenneth Douglas Rys

IPC: A61N1/05 ,  A61N1/372 ,  A61B17/34

CPC classification number: A61N1/372 ,  A61B17/3468 ,  A61N1/0558 ,  A61N1/37205 ,  A61N1/0556

Abstract: An implant insertion system and methods of use of the implant insertion system are disclosed. The implant insertion system includes an implant and an instrument configured to deliver the implant to a biological structure and assist in deploying the implant to the biological structure. The instrument includes a retention member the secures the implant to the instrument and retains the implant in a first configuration. The retention member is movable to decouple the implant from the instrument. The implant is configured to transition from the first configuration to a second configuration, such that in the second configuration the implant is secured to the biological structure.

公开(公告)号：US11571574B2

公开(公告)日：2023-02-07

申请号：US16348924

申请日：2017-11-10

Applicant: Galvani Bioelectronics Limited ,  Tokyo Metropolitan Institute of Gerontology

Inventor： Hans Jakob Kristoffer Famm ,  Harumi Hotta ,  Arun Sridhar

IPC: A61N1/36 ,  A61N1/05 ,  A61N5/06 ,  A61N7/02

Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).

公开(公告)号：US20230018108A1

公开(公告)日：2023-01-19

申请号：US17893924

申请日：2022-08-23

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin Hunsberger ,  Arun Sridhar

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.