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    Naphthyl- or isoquinolinyl-substituted isothiazoline compounds
    31.
    发明申请
    Naphthyl- or isoquinolinyl-substituted isothiazoline compounds 审中-公开
    萘基或异喹啉基取代的异噻唑啉化合物

    公开(公告)号：US20160374342A1

    公开(公告)日：2016-12-29

    申请号：US14757414

    申请日：2014-06-23

    Applicant: MERIAL, INC.

    Inventor： Pascal Bindschädler ,  Wolfgang Von Deyn ,  Karsten Körber ,  Deborah L. Culbertson ,  Koshi Gunjima ,  Franz Josef Braun

    IPC: A01N47/34 ,  A01N43/80 ,  C07D275/02

    CPC classification number: A01N47/34 ,  A01N43/80 ,  A01N47/30 ,  C07D275/02

    Abstract: The present invention relates to naphthyl- or isoquinolinyl-substituted isothiazoline compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

    Abstract translation: 其中变量如权利要求和描述中所定义。 这些化合物可用于对抗或控制无脊椎害虫，特别是节肢动物害虫和线虫。 本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。

    Haemophilus parasuis vaccine serovar type four
    32.
    发明授权
    Haemophilus parasuis vaccine serovar type four 有权
    嗜血杆菌疫苗血清型4型

    公开(公告)号：US09504740B2

    公开(公告)日：2016-11-29

    申请号：US14507397

    申请日：2014-10-06

    Applicant: MERIAL LIMITED

    Inventor： Paulraj Kirubakaran Lawrence ,  Russell F. Bey

    IPC: A61K39/102 ,  A61K39/00

    CPC classification number: A61K39/102 ,  A61K2039/521 ,  A61K2039/552 ,  A61K2039/70

    Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.

    Abstract translation: 本发明是针对血清型4型的嗜血杆菌疫苗，当作为杀死的疫苗施用于猪时，能够引发保护性免疫应答。 本发明还是一种通过以下方式，一种用于接种针对嗜血杆菌的副嗜血杆菌感染（4型血清型）的方法：a）克隆扩增一种或多种能够引发针对嗜血杆菌副嗜血杆菌感染的免疫应答的细胞，其可以保护猪免于 嗜血杆菌副嗜血杆菌感染，以及b）将免疫有效量的细胞与兽医学上可接受的载体以适合作为疫苗施用于猪的形式组合，以及c）作为灭活疫苗施用。 细胞培养来自病原性亲本菌株。

    1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
    34.
    发明授权
    1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof 有权
    1-芳基-5-烷基吡唑衍生物化合物，其制备方法及其使用方法

    公开(公告)号：US09339033B2

    公开(公告)日：2016-05-17

    申请号：US14325761

    申请日：2014-07-08

    Applicant: MERIAL, INC.

    Inventor： Loic Patrick Le Hir de Fallois ,  Hyoung Ik Lee ,  Philip Reid Timmons ,  William Glenn Cawthorne, Jr. ,  Adalberto Perez de Leon

    IPC: A01N43/56 ,  C07D401/04 ,  C07D231/18 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K45/06 ,  A01N25/02

    CPC classification number: A01N43/56 ,  A01N25/02 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K45/06 ,  C07D231/18 ,  C07D401/04

    Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.

    Abstract translation: 提供式（I）的1-芳基-5-烷基吡唑化合物：其中：R 1是氢，氰基，卤素，R 8，甲酰基，-C（O）R 8，-C（O）OR 8，-C ）NR 9 R 10或-C（S）NH 2; R2是R8或-S（O）mR11; R3是甲基，乙基或C1-C4卤代烷基; R4，R5和R7独立地是氢，卤素，烷基，卤代烷基，氰基或硝基; R 6是卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，氰基，硝基，-C（O）R 12，-S（O）n R 12或SF 5; Z是氮原子或C-R13; R8是烷基，卤代烷基，环烷基或卤代环烷基; R9是氢，烷基，卤代烷基或烷氧基; R 10是氢，烷基，卤代烷基或烷氧基; R11是烷基，卤代烷基，烯基，卤代烯基，炔基，卤代炔基或环烷基; R12是烷基或卤代烷基; R 13是氢，卤素，氰基，硝基，烷基，卤代烷基，烷氧基或卤代烷氧基; m为0,1或2; 且n为0,1或2; 或其盐，制备式（I）化合物的方法以及这些化合物对外寄生虫，内寄生虫和害虫的用途。

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