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314 条记录 (耗时 0.042 秒)

    OVINE GENOME EDITING WITH ZINC FINGER NUCLEASES
    31.
    发明申请
    OVINE GENOME EDITING WITH ZINC FINGER NUCLEASES 审中-公开
    使用ZINC指纹核的OVINE基因组编辑

    公开(公告)号：US20110023159A1

    公开(公告)日：2011-01-27

    申请号：US12842204

    申请日：2010-07-23

    申请人： Joseph Bedell ,  Brian Buntaine ,  Xiaoxia Cui

    发明人： Joseph Bedell ,  Brian Buntaine ,  Xiaoxia Cui

    IPC分类号： A01K67/027 ,  C12N5/10

    CPC分类号： C12N9/22 ,  A01K67/0275 ,  A01K2227/103 ,  C12N2800/80

    摘要： The present invention provides a genetically modified ovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the ovine genome.

    摘要翻译： 本发明提供了包含至少一个经编辑的染色体序列的遗传修饰的羊或细胞。 特别地，使用锌指核酸酶介导的编辑过程编辑染色体序列。 本公开还提供了针对羊基因组中特定染色体序列的锌指核酸酶。

    GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS
    34.
    发明申请
    GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS 审中-公开
    涉及动物肿瘤抑制基因的基因组编辑

    公开(公告)号：US20110023149A1

    公开(公告)日：2011-01-27

    申请号：US12842978

    申请日：2010-07-23

    申请人： Edward Weinstein ,  Xiaoxia Cui ,  Phil Simmons

    发明人： Edward Weinstein ,  Xiaoxia Cui ,  Phil Simmons

    IPC分类号： A61K49/00 ,  A01K67/027 ,  C12N5/10 ,  C12N9/16 ,  C07H21/04 ,  A61P43/00

    CPC分类号： C12N9/22 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0331 ,  C12N15/8509 ,  C12N2800/80

    摘要： The present invention provides genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence involved in tumor suppression and the nucleic acids encoding the zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression.

    摘要翻译： 本发明提供了转基因动物和细胞，其包括参与肿瘤抑制的编辑的染色体序列。 特别地，使用锌指核酸酶介导的编辑过程产生动物或细胞。 本发明还提供靶向涉及肿瘤抑制的染色体序列的锌指核酸酶和编码锌指核酸酶的核酸。 还提供了评价试剂在转基因动物和包含参与肿瘤抑制的编辑染色体序列的细胞中的作用的方法。

    GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE
    36.
    发明申请
    GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE 审中-公开
    心血管病相关基因的基因组编码

    公开(公告)号：US20110023139A1

    公开(公告)日：2011-01-27

    申请号：US12842198

    申请日：2010-07-23

    申请人： Edward Weinstein ,  Xiaoxia Cui ,  Phil Simmons

    发明人： Edward Weinstein ,  Xiaoxia Cui ,  Phil Simmons

    IPC分类号： A61K49/00 ,  A01K67/027 ,  C12N5/10 ,  C12N9/16 ,  C07H21/04 ,  A61P43/00

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0375 ,  C12N9/22 ,  C12N2800/80

    摘要： The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequences involved in cardiovascular disease and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.

    摘要翻译： 本发明提供了转基因动物和包含参与心血管疾病的染色体的细胞。 特别地，使用锌指核酸酶介导的编辑过程产生动物或细胞。 本发明还提供靶向参与心血管疾病的染色体序列的锌指核酸酶和编码所述锌指核酸酶的核酸。 还提供了使用本文公开的遗传修饰的动物或细胞来筛选毒性和其它作用的方法。

    Magnetic stirrer
    40.
    发明授权
    Magnetic stirrer 失效
    电磁搅拌器

    公开(公告)号：US07520657B2

    公开(公告)日：2009-04-21

    申请号：US11777592

    申请日：2007-07-13

    申请人： Bryan C. Andrews ,  Darryl B. Detwiler

    发明人： Bryan C. Andrews ,  Darryl B. Detwiler

    IPC分类号： B01F13/08

    CPC分类号： B01F13/0818 ,  B01F15/005

    摘要： A magnetic stirring system includes a stir-mantle and a magnetic stirring apparatus used for stirring/mixing materials in a flask. A rare-earth magnet is mounted on the magnetic stirring apparatus and is driven in rotation by a pneumatic motor. The rare-earth magnet is coupled to a magnetic stir bar in the flask for conjoint rotation so that the stir-bar stirs/mixes the materials in the flask. An exhaust is included to channel air from the motor to the rare-earth magnet and to direct the air to flow over the magnet to control the temperature of the magnet.

    摘要翻译： 磁力搅拌系统包括用于在烧瓶中搅拌/混合材料的搅拌器和磁力搅拌装置。 稀土磁铁安装在磁力搅拌装置上，由气动马达驱动旋转。 将稀土磁体与烧瓶中的磁力搅拌棒相连，以使其相互旋转，使得搅拌棒将烧瓶中的材料搅拌/混合。 包括排气以将空气从电动机引导到稀土磁体，并引导空气流过磁体以控制磁体的温度。