公开(公告)号：US20140330071A1

公开(公告)日：2014-11-06

申请号：US14309868

申请日：2014-06-19

申请人： Wisconsin Alumni Research Foundation

发明人： Hasan Khatib

IPC分类号： C12Q1/68 ,  A61D19/02 ,  A61D19/04

CPC分类号： C12Q1/6888 ,  A61D19/02 ,  A61D19/04 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/156

摘要： Single nucleotide polymorphic sites of the bovine HSP genes are associated with improved fertilization rate and/or improved embryo survival rate in cattle. Nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on these SNPs are disclosed.

摘要翻译： 牛HSP基因的单核苷酸多态性位点与牛的改良受精率和/或改良的胚胎存活率有关。 公开了基于这些SNP的核酸分子，试剂盒，基因分型方法和标记辅助的牛育种方法。

公开(公告)号：US20140309137A1

公开(公告)日：2014-10-16

申请号：US14314088

申请日：2014-06-25

申请人： NESTEC SA

发明人： Yuanlong Pan ,  Stephen S. Hannah ,  Rondo P. Middleton

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N2800/044

摘要： Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

摘要翻译： 公开了与改善或维持的瘦体重或减少的身体脂肪相关的基因表达谱。 在经受瘦素促进方案的动物的脂肪，肝脏和肌肉组织中测定基因表达谱，例如消耗高蛋白饮食，摄入共轭亚麻酸和/或增加运动。 还公开了使用这种简档来鉴定在动物中调节或有助于期望的表型的药物，营养药物，膳食物质或治疗方案的方法

公开(公告)号：US08759015B2

公开(公告)日：2014-06-24

申请号：US13549833

申请日：2012-07-16

申请人： Mark Zoller ,  Xiaodong Li ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

发明人： Mark Zoller ,  Xiaodong Li ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： G01N33/5041 ,  A01K2217/05 ,  C07K14/705 ,  C07K2319/00 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/566 ,  G01N2333/4719 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2500/04

摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

摘要翻译： 本发明涉及T1R受体组装形成功能性味觉受体的发现。 特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。 此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。 最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味 受体。

公开(公告)号：US08703413B2

公开(公告)日：2014-04-22

申请号：US13120192

申请日：2009-09-22

申请人： George Q. Daley ,  In-Hyun Park ,  Thorsten M. Schlaeger ,  Elayne Chan ,  Sutheera Ratanasirintrawoot

发明人： George Q. Daley ,  In-Hyun Park ,  Thorsten M. Schlaeger ,  Elayne Chan ,  Sutheera Ratanasirintrawoot

IPC分类号： G01N33/53 ,  G01N33/566 ,  G01N33/58

CPC分类号： G01N33/6872 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5073 ,  G01N33/53 ,  G01N33/536 ,  G01N33/56966 ,  G01N33/577 ,  G01N33/58 ,  G01N33/582 ,  G01N33/6854 ,  G01N2333/705 ,  G01N2333/70596 ,  G01N2333/90 ,  G01N2500/10

摘要： The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent.

摘要翻译： 本文描述的方法和试剂盒部分地基于代表完全重编程的iPS细胞和几种重编程中间体的发现表型。 本文描述的方法和试剂盒允许鉴定完全重编程的iPS细胞，并进一步允许本领域技术人员在重编程过程中监测iPS细胞的出现。 方法/试剂盒也可以使用活细胞成像实时进行。 本文还描述了通过在存在和不存在这种试剂的情况下监测完全重编程的iPS细胞的出现来筛选候选重编程剂的方法。

公开(公告)号：US08637652B2

公开(公告)日：2014-01-28

申请号：US13284425

申请日：2011-10-28

申请人： Robert Philibert ,  Anup Madan

发明人： Robert Philibert ,  Anup Madan

IPC分类号： C07H21/02 ,  G01N33/44

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/112 ,  C12Q2600/124 ,  C12Q2600/154 ,  Y10T436/143333 ,  C12Q2523/125

摘要： The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.

摘要翻译： 本发明提供筛选试剂盒，组合物和诊断方法，用于通过从受试者的生物样品中测定核酸甲基化谱，来确定受试者是否患有物质使用障碍的倾向或可能性，其中给定的分布 表明受试者具有物质使用障碍的倾向。

公开(公告)号：US20140005238A1

公开(公告)日：2014-01-02

申请号：US13899292

申请日：2013-05-21

申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： Ronald M. Evans ,  Vihang A. Narkar ,  Yong-Xu Wang ,  Michael Downes ,  Ruth T. Yu

IPC分类号： A61K31/426

CPC分类号： A61K31/426 ,  A61K31/4178 ,  A61K31/47 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPARδ agonist (e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPARδ activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPARδ and exercised-induced kinases (e.g., AMPK or its subunits, AMPK α1 and/or AMPK α2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.

摘要翻译： 本文公开了通过与运动程序结合施用PPARδ激动剂（例如，GW1516）来增强受试者的运动的一种或多种作用的方法。 还公开了激动剂诱导的PPARδ激活和运动的组合独特的基因表达谱。 至少在确定在锻炼对象（如专业人员或运动员）中使用性能增强药物的方法中，这种概况很有用。 PPARδ与锻炼诱导的激酶（例如AMPK或其亚基，AMPKα1和/或AMPKα2）之间的直接相互作用也被公开。 这种蛋白质 - 蛋白质相互作用提供了鉴定有用化合物的新靶标。

公开(公告)号：US20130306000A1

公开(公告)日：2013-11-21

申请号：US13471776

申请日：2012-05-15

申请人： Roger A. Coulombe ,  Kent Reed

发明人： Roger A. Coulombe ,  Kent Reed

IPC分类号： C12Q1/68 ,  C07K16/40 ,  A01K67/02 ,  C40B30/04 ,  C07H21/04 ,  C40B40/06 ,  C40B40/10

CPC分类号： C12Q1/6888 ,  A01K67/027 ,  A01K2227/30 ,  A01K2267/02 ,  C12Q2600/124 ,  C12Q2600/156

摘要： The present disclosure includes methods of improving the quality of poultry and the efficiency of its production. Specifically, single nucleotide polymorphisms (SNPs) have been identified in signature domains and conserved residues found in α-class turkey Glutathione S-Transferase (GSTA) genes. These SNPS correlate with aflatoxin resistance in turkeys. Thus, methods of screening for the relevant SNPs using polynucleotides and anti-peptide antibodies, kits that include these tools, and methods of breeding aflatoxin resistant flocks are provided herein.

摘要翻译： 本公开内容包括提高家禽质量及其生产效率的方法。 具体来说，在α类火鸡谷胱甘肽S-转移酶（GSTA）基因中发现的特征域和保守残基中鉴定了单核苷酸多态性（SNP）。 这些SNPS与火鸡中的黄曲霉毒素抗性相关。 因此，本文提供了使用多核苷酸和抗肽抗体筛选相关SNP的方法，包括这些工具的试剂盒以及育种黄曲霉毒素蛋白的方法。

公开(公告)号：US08450064B2

公开(公告)日：2013-05-28

申请号：US12719275

申请日：2010-03-08

申请人： Sue K. DeNise ,  Richard Kerr ,  David Rosenfeld ,  Tom Holm ,  Stephen Bates ,  Dennis Fantin

发明人： Sue K. DeNise ,  Richard Kerr ,  David Rosenfeld ,  Tom Holm ,  Stephen Bates ,  Dennis Fantin

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6881 ,  C12Q1/6827 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  Y02A90/26

摘要： Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide occurrence of at least one bovine SNP that is identified herein as being associated with the trait. The inference is used in methods of the present invention to establish the economic value of a bovine subject, to improve profits related to selling beef from a bovine subject; to manage bovine subjects, to sort bovine subjects; to improve the genetics of a bovine population by selecting and breeding of bovine subjects, to clone a bovine subject with a specific trait, to track meat or another commercial product of a bovine subject; and to diagnose a health condition of a bovine subject. Methods are also disclosed for identifying additional SNPs associated with a trait, by using the associated SNPs identified herein.

公开(公告)号：US20130080182A1

公开(公告)日：2013-03-28

申请号：US13245093

申请日：2011-09-26

申请人： James J. Kovach

发明人： James J. Kovach

IPC分类号： G06Q50/22

CPC分类号： C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172 ,  G16B20/00

摘要： Genetic screening is described which allows for the identification of athletes predisposed to physical conditions that could affect their performance. This, in turn, allows for associated personnel such as trainers, strength/conditioning coaches, and physicians, to develop pre-habilitation strategies that are personalized for the athlete's genetic and corresponding physical makeup.

摘要翻译： 描述了遗传筛选，其允许识别易受身体状况影响其性能的运动员。 这反过来又允许诸如训练者，力量/调理教练和医师等相关人员开发针对运动员的遗传和相应的身体构成个性化的预适应训练。

公开(公告)号：US20120128682A1

公开(公告)日：2012-05-24

申请号：US13388645

申请日：2010-08-18

申请人： Etienne Pays ,  Laurence Lecordier ,  Benolt Vanhollebeke

发明人： Etienne Pays ,  Laurence Lecordier ,  Benolt Vanhollebeke

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  A61K38/00 ,  A61K31/7088 ,  A61P3/06 ,  A61P33/00 ,  C12Q1/04 ,  G01N33/53 ,  C12Q1/68 ,  C07K16/12 ,  C12N5/10 ,  C07K16/18 ,  A01K67/027 ,  A61K35/14 ,  A61K35/16 ,  C07K14/775

CPC分类号： G01N33/92 ,  C07K14/775 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N2800/347

摘要： An isolated human Apolipoprotein L-I corresponding to a wild type human Apolipoprotein sequence is modified by a deletion at its C-terminal end.

摘要翻译： 对应于野生型人载脂蛋白序列的分离的人载脂蛋白L-1在其C末端被缺失修饰。