公开(公告)号：US09063161B2

公开(公告)日：2015-06-23

申请号：US13897712

申请日：2013-05-20

申请人： Entegrion, Inc.

发明人： Robert Glenn Dennis ,  Thomas H. Fischer ,  Joseph Anthony DaCorta

IPC分类号： G01N33/86 ,  G01N21/17 ,  G01N33/49 ,  G01N11/00

CPC分类号： G01N33/86 ,  G01N21/17 ,  G01N33/4905 ,  G01N2011/008

摘要： A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs between the two parallel planar surfaces. Detection of the coagulation response can be achieved through optical probing or by measurement of physical effects of the blood sample binding to the planar surfaces, and restricting movement thereof.

摘要翻译： 公开了一种装置，系统和方法，其中小体积血液样本经受施加线性运动轨迹的两个平行平面之间的剪切力和剪切应力。 由两个平行平面之间发生的动态机械耦合测量样品的凝块形成或凝结。 凝血反应的检测可以通过光学探测或通过测量结合于平面表面的血液样品的物理作用并限制其运动来实现。

公开(公告)号：US09012228B2

公开(公告)日：2015-04-21

申请号：US14357359

申请日：2012-12-12

申请人： Postech Academy-Industry Foundation

发明人： Dong Sung Kim ,  Moonwoo La ,  Sangmin Park

IPC分类号： G01N15/05 ,  G01N35/00 ,  G01N33/49 ,  G01N11/02 ,  G01N21/07 ,  G01N11/00

CPC分类号： G01N15/05 ,  B01L3/50273 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0688 ,  G01N11/02 ,  G01N21/07 ,  G01N33/491 ,  G01N35/00069 ,  G01N2011/008 ,  G01N2015/055 ,  G01N2035/00158 ,  Y10T436/111666 ,  Y10T436/25375

摘要： Provided is a method for checking a blood status including: a step of supplying blood to the centrifugal container of a disk; a step of rotating the disk to centrifuge the blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifugal container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph.

摘要翻译： 提供一种检查血液状态的方法，包括：向盘的离心容器供给血液的步骤; 旋转盘离心分离容器中的血细胞和血浆，并检测离心容器中血细胞的实际移动距离的步骤; 以及建立表示每小时血细胞的实际移动距离的第一图形的步骤，以及表示每小时血细胞的理论移动距离的第二图形，然后计算血细胞的血细胞比容和粘度 通过将第一图与第二图进行比较来获得血浆。

公开(公告)号：US20140315317A1

公开(公告)日：2014-10-23

申请号：US14357359

申请日：2012-12-12

申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION

发明人： Dong Sung Kim ,  Moonwoo La ,  Sangmin Park

IPC分类号： G01N15/05 ,  G01N35/00

CPC分类号： G01N15/05 ,  B01L3/50273 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0688 ,  G01N11/02 ,  G01N21/07 ,  G01N33/491 ,  G01N35/00069 ,  G01N2011/008 ,  G01N2015/055 ,  G01N2035/00158 ,  Y10T436/111666 ,  Y10T436/25375

摘要： A method for checking blood status comprises: a step of supplying blood to the centrifuge container of a disk; a step of rotating the disk to centrifuge the blood into blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifuge container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph.

摘要翻译： 一种用于检查血液状态的方法，包括：向盘的离心容器供给血液的步骤; 旋转盘将离心机中的血液离心成血细胞和血浆的步骤，并且检测离心机容器中每小时血细胞的实际移动距离; 以及建立表示每小时血细胞的实际移动距离的第一图形的步骤，以及表示每小时血细胞的理论移动距离的第二图形，然后计算血细胞的血细胞比容和粘度 通过将第一图与第二图进行比较来获得血浆。

公开(公告)号：US20140232853A1

公开(公告)日：2014-08-21

申请号：US13773259

申请日：2013-02-21

申请人： Neil E. Lewis

发明人： Neil E. Lewis

IPC分类号： G01N11/04

CPC分类号： G01N11/06 ,  G01N11/04 ,  G01N2011/008

摘要： In one general aspect, a capillary viscometer is disclosed that includes a source of fluid pressure, and a first capillary tube having an inside volume that is hydraulically responsive to the source of fluid pressure. A two-dimensional array of optical detectors is positioned proximate the first capillary tube with a first plurality of its detectors optically responsive to the inside volume of the first capillary tube and including an image data output. An acquisition driver circuit is responsive to the image data output of the two-dimensional array to acquire a series of successive images of the inside volume of the first capillary tube. Viscosity computation logic is responsive to the acquisition driver circuit and operative to compute the viscosity of the fluid from the succession of images of the inside volume of the first capillary tube.

摘要翻译： 在一个一般方面，公开了一种包括流体压力源的毛细管粘度计，以及具有液压响应于流体压力源的内部体积的第一毛细管。 光学检测器的二维阵列定位在第一毛细管附近，其中第一多个检测器对第一毛细管的内部体积进行光学响应并且包括图像数据输出。 采集驱动器电路响应于二维阵列的图像数据输出，以获取第一毛细管的内部体积的一系列连续图像。 粘度计算逻辑响应于采集驱动器电路并可操作以从第一毛细管的内部体积的连续图像计算流体的粘度。

公开(公告)号：US20130003061A1

公开(公告)日：2013-01-03

申请号：US13390915

申请日：2010-08-17

申请人： Samiul Amin ,  Carlos Alberto Rega

发明人： Samiul Amin ,  Carlos Alberto Rega

IPC分类号： G01N21/49

CPC分类号： G01N21/51 ,  G01N11/00 ,  G01N15/1436 ,  G01N21/03 ,  G01N2011/008 ,  G01N2021/0346 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/513 ,  G01N2201/08

摘要： A fluid characterization measuring instrument comprises a sample vessel (14) for a bulk complex sample fluid having a capacity that is substantially larger than a domain size of the complex sample fluid and that is sufficiently large to cause bulk scattering effects to substantially exceed surface effects for the complex fluid sample, a coherent light source (12) positioned to illuminate the bulk complex sample fluid in the sample vessel and a first fibre (16) having a first end positioned to receive backscattered light from the sample after it has interacted with the sample. The first fibre is positioned close enough to an optical axis of the coherent light source and to the sample vessel to substantially decrease a contribution of multiply scattered light in the backscattered light. The instrument further comprises a first photon-counting detector (20) positioned to receive the backscattered light from a second end of the fibre, correlation logic (22) responsive to the first photon-counting detector and single-scattering fluid property analysis logic responsive to the correlation logic and operative to derive at least one fluid property for the sample fluid.

摘要翻译： 流体表征测量仪器包括用于大体积复合物样品流体的样品容器（14），其具有基本上大于复杂样品流体的域尺寸的能力，并且足够大以引起体散射效应，从而基本上超过表面效应 所述复杂流体样品，定位成照射所述样品容器中的本体复合物样品流体的相干光源（12）和具有第一端的第一光纤（16），所述第一光纤定位成在与所述样品相互作用后接收来自所述样品的反向散射光 。 第一光纤被定位成足够靠近相干光源的光轴并且到达样品容器，以显着降低多个散射光在反向散射光中的贡献。 所述仪器还包括第一光子计数检测器（20），其定位成从所述光纤的第二端接收所述反向散射光，所述相关逻辑（22）响应于所述第一光子计数检测器和响应于所述第一光子计数检测器的单散射流体属性分析逻辑 相关逻辑并且可操作地导出用于样品流体的至少一种流体性质。

公开(公告)号：US08335343B2

公开(公告)日：2012-12-18

申请号：US12511675

申请日：2009-07-29

申请人： Gregory P. Martiska ,  Paula L. Martiska

发明人： Gregory P. Martiska ,  Paula L. Martiska

IPC分类号： G06K9/00

CPC分类号： G01F23/2925 ,  G01N11/00 ,  G01N2011/008 ,  G01N2033/0091

摘要： A method is provided for characterizing powders and powder behavior in a rotating cylindrical container by image analysis techniques. Powder is placed in a generally cylindrical container with transparent ends. The container is then placed in front of an imaging device and illuminated with a light source so the device can capture images of the powder over time. The container is then rotated at various speeds and the camera captures images of the powder at fixed time intervals. Image analysis algorithms are then used to isolate the powder information in the images and this data is used to calculate several parameters of the powder including the potential energy of the powder, the curvature of the powder, and volume of the powder. From these calculations, the average potential energy level of the powder, the potential energy level at which the powder yields or avalanches, the change in the potential energy before and after an avalanche, the powder surface curvature, and powder volume can be determined as a function of container rotation speed.

摘要翻译： 提供了一种通过图像分析技术在旋转圆柱形容器中表征粉末和粉末行为的方法。 将粉末放置在具有透明端部的大致圆柱形的容器中。 然后将容器放置在成像装置的前面并用光源照射，使得装置可随时间捕获粉末的图像。 然后以各种速度旋转容器，相机以固定的时间间隔捕获粉末的图像。 然后使用图像分析算法分离图像中的粉末信息，该数据用于计算粉末的几个参数，包括粉末的势能，粉末的曲率和粉末的体积。 从这些计算，粉末的平均势能水平，粉末产生或崩溃的势能水平，雪崩前后的势能变化，粉末表面曲率和粉末体积可以被确定为 集装箱转速功能。

公开(公告)号：US20120288926A1

公开(公告)日：2012-11-15

申请号：US13511605

申请日：2010-10-27

申请人： Takanori Murayama

发明人： Takanori Murayama

IPC分类号： C12M1/34

CPC分类号： G01N11/04 ,  G01N33/4905 ,  G01N2011/008 ,  G01N2015/0092

摘要： Disclosed is a blood cell trajectory display device (1) for displaying the blood cell trajectory leading to an agglutination, that is equipped with a TV camera (3) for sequential photographing the flow of blood, a calculation unit (70) that analyzes the blood flow images obtained by the TV camera (3), and a display (8). The calculation unit (70) analyzes a plurality of blood flow image frames and detects the agglutination of blood cells in the blood, and in cases in which blood cell agglutination has been detected, detects the position of said blood cells in the blood flow image frame prior to the frame in which the agglutination was detected, and requests the trajectory of said blood cells to the agglutination point. The display (8) displays the blood cell trajectory requested by the calculation unit (70).

摘要翻译： 公开了一种用于显示导致凝集的血细胞轨迹的血细胞轨迹显示装置（1），其配备有用于顺序拍摄血流的电视摄像机（3），分析血液的计算单元（70） 由电视摄像机（3）获得的流动图像和显示器（8）。 计算单元（70）分析多个血流图像帧并检测血液中血细胞的凝集，并且在检测到血细胞凝集的情况下，检测血流图像帧中的所述血细胞的位置 在检测到凝集的框架之前，并且请求所述血细胞的轨迹到凝集点。 显示器（8）显示由计算单元（70）请求的血球轨迹。

公开(公告)号：US20120094867A1

公开(公告)日：2012-04-19

申请号：US13320879

申请日：2010-05-25

申请人： Sang-Kyu Lee ,  Sandra W. Ramer ,  Amr R. Toppozada

发明人： Sang-Kyu Lee ,  Sandra W. Ramer ,  Amr R. Toppozada

IPC分类号： C40B30/10

CPC分类号： G01N11/14 ,  G01N2011/008

摘要： Described are compositions and methods related to determining the rate of viscosity change in a suspension in real time. The compositions and methods have a broad range of applications, including the measurement of amylase-mediated liquefaction of a starch suspension.

摘要翻译： 描述了与实时确定悬浮液中粘度变化速率有关的组合物和方法。 组合物和方法具有广泛的应用范围，包括淀粉酶介导的淀粉悬浮液液化的测量。

公开(公告)号：US20110252871A1

公开(公告)日：2011-10-20

申请号：US13085563

申请日：2011-04-13

申请人： Toshiyuki Nagoshi ,  Jun Koshoubu ,  Mitsuo Watanabe ,  Takashi Inoue ,  Shigeru Ito

发明人： Toshiyuki Nagoshi ,  Jun Koshoubu ,  Mitsuo Watanabe ,  Takashi Inoue ,  Shigeru Ito

IPC分类号： G01N11/14 ,  G01N3/00

CPC分类号： G01N11/142 ,  G01N2011/008 ,  G01N2203/0092

摘要： Measuring apparatus comprises a rotating plate 17, a torque detection plate 18 disposed on a same axis parallel to the plate 17 with a given gap, a torque sensor about the plate 18 through the specimen held between two plates. The plate 18 is a total reflection prism which is made from a material that has a greater refractive index than the specimen and transmits UV and infrared light. An ultraviolet beam is directed onto the specimen through the prism. An infrared beam is directed into the prism. The infrared beam emerging from the prism after total reflection from the interface between the prism and the specimen is detected. A signal processor analyzes the infrared absorption spectrum of the specimen on the basis of the infrared beam. While the viscosity of the specimen in the curing process is measured, the signal processor simultaneously measures the infrared absorption spectrum.

摘要翻译： 测量装置包括旋转板17，以与给定间隙平行于板17的同一轴线设置的扭矩检测板18，通过保持在两个板之间的试样围绕板18的转矩传感器。 板18是由具有比样本更大的折射率的材料制成并透射紫外线和红外光的全反射棱镜。 紫外光束通过棱镜被引导到样品上。 红外光束被引导到棱镜中。 检测从棱镜和样品之间的界面全反射后从棱镜出射的红外光束。 信号处理器基于红外光束分析样品的红外吸收光谱。 当测量固化过程中样品的粘度时，信号处理器同时测量红外吸收光谱。

公开(公告)号：US20110026760A1

公开(公告)日：2011-02-03

申请号：US12511675

申请日：2009-07-29

申请人： Gregory P. Martiska ,  Paula L. Martiska

发明人： Gregory P. Martiska ,  Paula L. Martiska

IPC分类号： G06K9/00

CPC分类号： G01F23/2925 ,  G01N11/00 ,  G01N2011/008 ,  G01N2033/0091

摘要： A method is provided for characterizing powders and powder behavior in a rotating cylindrical container by image analysis techniques. Powder is placed in a generally cylindrical container with transparent ends. The container is then placed in front of an imaging device and illuminated with a light source so the device can capture images of the powder over time. The container is then rotated at various speeds and the camera captures images of the powder at fixed time intervals. Image analysis algorithms are then used to isolate the powder information in the images and this data is used to calculate several parameters of the powder including the potential energy of the powder, the curvature of the powder, and volume of the powder. From these calculations, the average potential energy level of the powder, the potential energy level at which the powder yields or avalanches, the change in the potential energy before and after an avalanche, the powder surface curvature, and powder volume can be determined as a function of container rotation speed.

摘要翻译： 提供了一种通过图像分析技术在旋转圆柱形容器中表征粉末和粉末行为的方法。 将粉末放置在具有透明端部的大致圆柱形的容器中。 然后将容器放置在成像装置的前面并用光源照射，使得装置可随时间捕获粉末的图像。 然后以各种速度旋转容器，相机以固定的时间间隔捕获粉末的图像。 然后使用图像分析算法分离图像中的粉末信息，该数据用于计算粉末的几个参数，包括粉末的势能，粉末的曲率和粉末的体积。 从这些计算，粉末的平均势能水平，粉末产生或崩溃的势能水平，雪崩前后的势能变化，粉末表面曲率和粉末体积可以被确定为 集装箱转速功能。