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    Micro-lens imaging multi-well test plate
    31.
    发明申请
    Micro-lens imaging multi-well test plate 审中-公开

    公开(公告)号：US20190120758A1

    公开(公告)日：2019-04-25

    申请号：US16220020

    申请日：2018-12-14

    Applicant: JINAN UNIVERSITY

    Inventor： Yaoxiong HUANG ,  Jiang He

    IPC: G01N21/41 ,  G01N21/43 ,  G02B13/00

    CPC classification number: G01N21/4133 ,  G01N21/0303 ,  G01N21/253 ,  G01N21/431 ,  G01N2021/0307 ,  G01N2021/0382 ,  G01N2201/0639 ,  G02B13/0055

    Abstract: Disclosed is a micro-lens imaging multi-well test plate which comprises: a transparent plate of 3-5 mm in thickness with one or more trapezoidal wells locating in the middle of the plate, each of the wells is of an underside of 2-4 mm in diameter, 0.2-0.5 mm in thickness, a trapezoidal dip angle of 60-75°, and has a micro-lens which upper half is hemispherical, lower half is a cylinder, with radius of 0.1˜1.0 mm, height of 0.2˜2.5 mm, molded on the bottom of the well. The micro-lens imaging multi-well test plate is made of homogeneous optical transparent materials. When the trapezoidal concave wells of the test plate are filled with fluid to immerse the micro-lens, under parallel light illumination, due to the refraction effect of light, the image of micro-lens is a round one with an outer edge that is a black ring. The outer radius R of the black ring is the radius of the micro-lens, the inner radius r of the black ring is a function of the refractive index n1 of the immersion liquid, the refractive index n2 of the micro-lens and the height h of the micro-lens, so the refractive index of the sample fluid can be determined by monitoring the value of the inner radius r of the black ring with known values of R, n2 and h. By using a multi-well test plate for imaging, the individual refractive indices of different sample fluids in all the wells can be determined simultaneously in one measurement.

    SMOKE-DETECTING PHOTOSENSOR
    32.
    发明申请
    SMOKE-DETECTING PHOTOSENSOR 审中-公开

    公开(公告)号：US20180306715A1

    公开(公告)日：2018-10-25

    申请号：US15826748

    申请日：2017-11-30

    Applicant: Murata Manufacturing Co., Ltd.

    Inventor： Tsutomu YAMASAKI

    IPC: G01N21/53

    CPC classification number: G01N21/53 ,  G01N2201/0639

    Abstract: A light-emission-side prism accommodates a light-emitting element and is disposed in a light-emission guide hole extending in a light-emission axis direction. A light-reception-side prism accommodates a light-receiving element and is disposed in a light-reception guide hole extending in a light-reception axis direction. The light-emission-side prism has a total-reflection surface that causes light from the light-emitting element to be directed in the light-emission axis direction and a lens surface that causes light emitted from the total-reflection surface to be condensed. The light-reception-side prism includes a lens surface that causes scattered light entering from a smoke monitoring area in the light-reception axis direction to be condensed and a total-reflection surface that causes light condensed by the lens surface to be directed toward the light-receiving element.

    Depth-selective fiber-optic probe
    33.
    发明授权
    Depth-selective fiber-optic probe 有权
    深度选择性光纤探头

    公开(公告)号：US09451885B2

    公开(公告)日：2016-09-27

    申请号：US13991459

    申请日：2011-12-15

    Applicant: Yang Liu

    Inventor： Yang Liu

    IPC: A61B5/00 ,  A61B1/00 ,  A61B1/07 ,  A61B5/1455 ,  G01N21/47 ,  G02B6/32

    CPC classification number: A61B5/0084 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/0017 ,  A61B1/00188 ,  A61B1/07 ,  A61B5/0075 ,  A61B5/1455 ,  A61B5/443 ,  A61B5/444 ,  A61B2560/0233 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2201/0639 ,  G02B6/32 ,  Y10T29/49826

    Abstract: Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams.

    Abstract translation: 本文中讨论了至少部分地基于深度选择性光纤探针来促进浅表组织分析的系统和方法。 深度选择性光纤探针可以包括用于向表面组织提供光的照明光纤，用于收集的反射光的收集光纤，耦合光纤的球形透镜以及容纳球透镜和光纤的保护外套管。 可以基于几个因素来优化球透镜和纤维之间以及纤维之间的距离，例如通过使照明光点尺寸最小化，使照明和收集点之间的重叠最大化，并且基于照明和收集光束之间的角度 。

    MULTICHANNEL ANALYTICAL INSTRUMENTS FOR USE WITH SPECIMEN HOLDERS
    34.
    发明申请
    MULTICHANNEL ANALYTICAL INSTRUMENTS FOR USE WITH SPECIMEN HOLDERS 审中-公开

    公开(公告)号：US20160025616A1

    公开(公告)日：2016-01-28

    申请号：US14873036

    申请日：2015-10-01

    Applicant: Laxco, Inc.

    Inventor： Cong Liang CHEN ,  Kevin CASSADY

    IPC: G01N21/03 ,  G01N21/27

    CPC classification number: G01N21/0303 ,  G01N21/01 ,  G01N21/17 ,  G01N21/253 ,  G01N21/27 ,  G01N21/6452 ,  G01N2201/0639 ,  G01N2201/08 ,  G01N2201/0826 ,  G02B6/006 ,  G02B6/04 ,  G02B6/29388 ,  G02B6/32

    Abstract: An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern.

    Multichannel analytical instruments for use with specimen holders
    35.
    发明授权
    Multichannel analytical instruments for use with specimen holders 有权
    用于样品架的多通道分析仪器

    公开(公告)号：US09182336B2

    公开(公告)日：2015-11-10

    申请号：US13782950

    申请日：2013-03-01

    Applicant: Laxco, Inc.

    Inventor： Cong Liang Chen ,  Kevin Cassady

    IPC: G01N21/01 ,  G01N21/17 ,  G02B6/04 ,  G01N21/25 ,  G02B6/32 ,  F21V8/00 ,  G02B6/293

    CPC classification number: G01N21/0303 ,  G01N21/01 ,  G01N21/17 ,  G01N21/253 ,  G01N21/27 ,  G01N21/6452 ,  G01N2201/0639 ,  G01N2201/08 ,  G01N2201/0826 ,  G02B6/006 ,  G02B6/04 ,  G02B6/29388 ,  G02B6/32

    Abstract: An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern.

    Abstract translation: 分析仪器可能具有多个不同的通道。 这样可以包括一个或多个照明源和传感器。 照明可以被传送到样本保持器的特定位置，并且返回的照明可以被传送到传感器阵列的特定位置。 照明可以首先通过样本，然后镜子或反射器可以使照射通过样本。 可以使用光分路器将靠近样本保持器的成对的光纤耦合。 这样的通道还可以包括位于样品架一侧的多个照明源和另一侧的多个传感器。 多个传感器可以捕获样本的图像，并且分光光度计可以同时扫描样本。 可以在多次通过的单次通过中对多个样本进行成像和扫描。 球形或球形透镜可以放置在照明的光路中以实现期望的照明图案。

    Optical metrology using a photonic nanojet
    38.
    发明授权
    Optical metrology using a photonic nanojet 失效
    光学计量学使用光子纳米喷墨

    公开(公告)号：US07394535B1

    公开(公告)日：2008-07-01

    申请号：US11726083

    申请日：2007-03-20

    Applicant: Zhigang Chen ,  Hanyou Chu ,  Shifang Li

    Inventor： Zhigang Chen ,  Hanyou Chu ,  Shifang Li

    IPC: G01N21/00

    CPC classification number: G01N21/9501 ,  B82Y20/00 ,  G01B11/2518 ,  G01N21/94 ,  G01N21/95607 ,  G01N2201/0639 ,  H01L22/12

    Abstract: An inspection area on a semiconductor wafer can be examined using a photonic nanojet. The photonic nanojet, an optical intensity pattern induced at a shadow-side surface of a dielectric microsphere, is generated. The inspection area is scanned with the photonic nanojet. A measurement is obtained of the retroreflected light from the dielectric microsphere as the photonic nanojet scans the inspection area. The existence of a structure in the inspection area is determined with the obtained measurement of the retroreflected light.

    Abstract translation: 可以使用光子纳米喷嘴来检查半导体晶片上的检查区域。 产生光子纳米喷墨，在电介质微球的阴影侧表面处引起的光强度图案。 用光子纳米喷枪扫描检查区域。 当光子纳米喷墨扫描检查区域时，获得来自电介质微球的回射光的测量。 通过获得的回射光的测量来确定检查区域中的结构的存在。

    Turbidity sensor
    39.
    发明授权
    Turbidity sensor 有权
    浊度传感器

    公开(公告)号：US06842243B2

    公开(公告)日：2005-01-11

    申请号：US10315142

    申请日：2002-12-10

    Applicant: Eugene Tokhtuev ,  Christopher Owen ,  Anatoly Skirda ,  Viktor Slobodyan ,  José Goin

    Inventor： Eugene Tokhtuev ,  Christopher Owen ,  Anatoly Skirda ,  Viktor Slobodyan ,  José Goin

    IPC: G01N21/53 ,  G01N21/00

    CPC classification number: G01N21/53 ,  G01N2201/0639

    Abstract: A small size turbidity sensor for underwater in-situ measurements in the wide range of turbidity values is disclosed that may be integrated into a housing with other underwater sensors. The turbidity sensor incorporates micro focusing devices and light stop that gives no divergence excitation beam with convergence less than 1.5 degrees and the measuring angle between the optical axis of the incident radiation and mat of the diffused radiation 90 ±2.5 degrees. Another embodiment includes internal and external optical calibrators that allows the sensor to work longer without human intervention.

    Abstract translation: 公开了一种用于大范围浊度值的水下原位测量的小尺寸浊度传感器，其可以与其它水下传感器集成到壳体中。 浊度传感器包含微聚焦装置和光停止器，其不产生会聚小于1.5度的发散激发光束，并且入射辐射的光轴与漫射辐射的光束之间的测量角度为90±2.5度。 另一个实施例包括内部和外部光学校准器，其允许传感器在没有人为干预的情况下工作更长时间。

    Laser-induced fluorescence detector having a capillary detection cell and method for identifying trace compounds implemented by the same device
    40.
    发明授权
    Laser-induced fluorescence detector having a capillary detection cell and method for identifying trace compounds implemented by the same device 失效
    具有毛细管检测单元的激光诱导荧光检测器和用于鉴别由相同装置实施的痕量化合物的方法

    公开(公告)号：US5926271A

    公开(公告)日：1999-07-20

    申请号：US982256

    申请日：1997-12-01

    Applicant: Francois Couderc ,  Michel Nertz ,  Georges Nouadje

    Inventor： Francois Couderc ,  Michel Nertz ,  Georges Nouadje

    IPC: G01N21/63 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N30/74 ,  G01J3/30

    CPC classification number: G01N21/05 ,  G01N21/6402 ,  G01N21/645 ,  G01N27/44721 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2021/6467 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2201/0639

    Abstract: A laser-induced fluorescence detector comprises a laser beam emitting device, a dichroic mirror to deviate the laser light orthogonally, a lens with a small numerical aperture, a ball lens, a unique cell within a capillary, the cell receiving a solute containing at least one unknown fluorescent substance at the laser wavelength, the same device collecting the fluorescence emitted by the fluorescent substance, with optical filters, a photomultiplier tube, and a computer for displaying results of the analysis. The ball lens converts the laser beam into a very small divergent beam, which allows a high irradiated volume in the capillary cell. The cell employs controlled geometric contours to prevent laminar mixing and turbulence during liquid flow, and the collecting device is a high numerical aperture device, for example, a ball lens.

    Abstract translation: 激光诱导荧光检测器包括激光束发射装置，正交偏转激光的二向色镜，具有小数值孔径的透镜，球透镜，毛细管内的独特细胞，细胞接收至少含有溶质 在激光波长处的一种未知的荧光物质，与荧光物质发射的荧光相同的装置，光学滤光器，光电倍增管和用于显示分析结果的计算机。 球形透镜将激光束转换成非常小的发散光束，这允许毛细管电池中的高照射体积。 电池采用受控的几何轮廓，以防止液体流动期间的层流混合和湍流，并且收集装置是高数值孔径装置，例如球形透镜。

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