公开(公告)号：US20200038555A1

公开(公告)日：2020-02-06

申请号：US16529973

申请日：2019-08-02

申请人： VeriGraft AB

发明人： Raimund Strehl

IPC分类号： A61L27/50 ,  C12M3/00 ,  C12M1/34 ,  G01N33/66 ,  C12M1/00 ,  A61L27/38 ,  A61L33/00

摘要： The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.

公开(公告)号：US10537668B2

公开(公告)日：2020-01-21

申请号：US16381789

申请日：2019-04-11

申请人： Bactiguard AB

发明人： Mattias Ohrlander ,  Billy Södervall

IPC分类号： A61L31/08 ,  A01N59/16 ,  A61L2/238 ,  A61L27/30 ,  A61L27/50 ,  A61L29/10 ,  A61L33/00 ,  B32B27/00 ,  C23C18/16 ,  C23C18/18 ,  C23C18/42 ,  C23C18/44 ,  C23C26/00 ,  C23C30/00 ,  B32B5/30 ,  B32B9/00 ,  B32B15/16 ,  B32B27/14 ,  B32B27/16 ,  B32B5/16 ,  A01N25/08 ,  A61K9/00 ,  A61K33/24 ,  A61K33/38 ,  A61L26/00 ,  B05D3/02 ,  A61L31/02 ,  A61L31/04 ,  A61L31/06

摘要： There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

公开(公告)号：US10456227B2

公开(公告)日：2019-10-29

申请号：US15640873

申请日：2017-07-03

申请人： Ension, Inc.

发明人： Ali Hussain ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Jeffrey W. Speakman

IPC分类号： A61C15/04 ,  A61B17/06 ,  A61B17/064 ,  A61L31/04 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  A61M1/16 ,  B05D7/02 ,  B05D1/36 ,  B05D1/00

摘要： A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

公开(公告)号：US10385151B2

公开(公告)日：2019-08-20

申请号：US15581703

申请日：2017-04-28

申请人： FUJIFILM Corporation

发明人： Kiyotaka Fukagawa

IPC分类号： C08F220/60 ,  C08F228/02 ,  A61L27/00 ,  A61L29/00 ,  A61L31/00 ,  A61L33/00 ,  C08F20/60 ,  A61L27/34 ,  A61L31/10 ,  C08F220/18 ,  C08F220/28

摘要： A material non-adhesive to a biological substance containing: a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (I) or (II). In the formulae, R1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, a plurality of R1's may be the same as or different from each other. R2 represents a hydrogen atom or a methyl group. n represents an integer of 2 to 4. L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

公开(公告)号：US20190248942A1

公开(公告)日：2019-08-15

申请号：US16395145

申请日：2019-04-25

申请人： FUJIFILM Corporation

发明人： Kiyotaka FUKAGAWA

IPC分类号： C08F220/60 ,  A61L31/10 ,  A61L29/00 ,  A61L31/00 ,  C08F228/02 ,  C08F220/28 ,  C08F220/18 ,  A61L27/00 ,  A61L27/34 ,  C08F20/60 ,  A61L33/00

CPC分类号： C08F220/60 ,  A61L27/00 ,  A61L27/34 ,  A61L29/00 ,  A61L31/00 ,  A61L31/10 ,  A61L33/00 ,  C08F20/60 ,  C08F220/18 ,  C08F220/28 ,  C08F228/02 ,  C08F2220/1825 ,  C08F2220/603 ,  C08F2220/606

摘要： A material non-adhesive to a biological substance containing: a polymer compound (A) which includes a repeating unit derived from a sulfobetaine monomer represented by Formula (I) or (II). In the formulae, R1 represents a methyl group, an ethyl group, an n-propyl group, or an isopropyl group, a plurality of R1's may be the same as or different from each other.R2 represents a hydrogen atom or a methyl group.n represents an integer of 2 to 4.L represents a linear or branched alkylene group having 3 or 4 carbon atoms.

公开(公告)号：US10376682B2

公开(公告)日：2019-08-13

申请号：US15290129

申请日：2016-10-11

申请人： The Johns Hopkins University

发明人： Chao-Wei Hwang ,  Hala J. Tomey ,  Jon R. Resar ,  Robert C. Matteson, III ,  George L. Coles, Jr. ,  Jason J. Benkoski ,  Morgana M. Trexler

IPC分类号： A61M31/00 ,  A61F2/82 ,  A61K9/00 ,  A61L31/16 ,  A61L31/14 ,  A61L33/00 ,  B05D1/00 ,  C23C14/22

摘要： Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

公开(公告)号：US10350334B2

公开(公告)日：2019-07-16

申请号：US15659960

申请日：2017-07-26

申请人： Becton, Dickinson and Company

发明人： John J. Kelley, III ,  Thelma I. Valdes

IPC分类号： A61L33/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/47 ,  A61K9/00 ,  A61K31/445 ,  A61L29/14 ,  A61L29/16 ,  A61L29/06 ,  A61L33/04 ,  A61L33/06 ,  A61K47/36 ,  A61M25/00

摘要： The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

公开(公告)号：US20190175015A1

公开(公告)日：2019-06-13

申请号：US16302750

申请日：2017-05-31

申请人： QURA, INC.

发明人： Douglas P. ADAMS ,  Celso TELLO ,  Marcel David ACKERMANN ,  Jean-Noël FEHR

IPC分类号： A61B3/16 ,  A61L31/08 ,  A61L31/14 ,  A61L33/00 ,  A61L33/18 ,  A61B5/00

摘要： Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor.

公开(公告)号：US20190125555A1

公开(公告)日：2019-05-02

申请号：US16173879

申请日：2018-10-29

申请人： Covidien LP

发明人： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC分类号： A61F2/82 ,  A61F2/06 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61L31/02 ,  A61L33/06 ,  A61L31/14 ,  A61L33/00

摘要： Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US10251742B2

公开(公告)日：2019-04-09

申请号：US15117941

申请日：2015-02-12

申请人： Toray Industries, Inc.

发明人： Masaki Fujita ,  Koji Kadowaki ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi ,  Hiroshi Tsuchikura ,  Satoshi Yamada

IPC分类号： A61F2/06 ,  A61F2/89 ,  D03D3/02 ,  D03D15/00 ,  A61L27/50 ,  A61L33/00 ,  A61L27/18 ,  A61L33/06

摘要： An artificial blood vessel is composed of a cylindrical multiple-woven fabric structure allowing only a small amount of blood leakage and can achieve both antithrombogenicity and cellular affinity. The artificial blood vessel includes a cylindrical fabric structure in which a cylindrical fabric whose inside contacts blood is arranged, wherein the cylindrical fabric is a fabric prepared by interlacing a plurality of warp yarns and a plurality of weft yarns with each other into a cylindrical shape; the warp yarns and the weft yarns constituting the cylindrical fabric include a multifilament yarn having a single yarn fineness of not more than 0.50 dtex, and are bound to an antithrombogenic material; the antithrombogenic material forms an antithrombogenic material layer having a thickness of 1 to 600 nm inside the cylindrical fabric; and the water permeability under conditions where a pressure of 16 kPa is applied to the inner surface is less than 300 mL/cm2/min.