公开(公告)号：US20140069537A1

公开(公告)日：2014-03-13

申请号：US14080826

申请日：2013-11-15

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach

IPC: F17D1/14

CPC classification number: F04B43/14 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2400/0655 ,  F04B43/043 ,  Y10T137/85978

Abstract: The invention concerns a circuit comprising a bag (111) comprising two flexible films (145, 146) and routing network connectors, and a press (110) comprising a first shell (114) and a second shell (113) clamping the bag to form pipes (104) between the films, the first shell comprising a pinch valve (120) which comprises an actuator (121) comprising a movable member (124) and in register with the moveable member an elastically compressible pad (131) which, when the valve is in an open position, has a resting configuration in which a second face (33) of the pad is concave and locally delimits a shaping channel (118), and, when the valve is in a closed position, has a pinching configuration in which the second face (133) is convex, with the pipe and the pad sandwiched between a shaping channel (116) and the moveable member.

Abstract translation: 本发明涉及一种包括包括两个柔性膜（145,146）和布线网络连接器的袋（111）的电路，以及包括第一壳（114）和第二壳（113）的压力机（110），所述第一壳体（114）和第二壳体 所述薄膜之间的管道（104），所述第一壳体包括夹管阀（120），所述夹管阀包括致动器（121），所述致动器包括可动构件（124）并与所述可移动构件对准可弹性压缩垫（131） 阀处于打开位置，具有静止构型，其中垫的第二面（33）是凹形的并且局部限定成形通道（118），并且当阀处于关闭位置时，具有夹紧构型 其中第二面（133）是凸的，管和衬垫夹在成形通道（116）和可移动构件之间。

公开(公告)号：US20140051157A1

公开(公告)日：2014-02-20

申请号：US14065136

申请日：2013-10-28

Applicant: EMD MILLIPORE CORPORATION

Inventor： Fedor Ilkov

IPC: G01N21/01 ,  G02B19/00

CPC classification number: G01N21/01 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/53 ,  G01N21/6486 ,  G01N2015/1006 ,  G02B19/0028 ,  G02B19/0076

Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

Abstract translation: 在包括用于通过含有待分析颗粒的流体的毛细管的颗粒分析装置中，使用光学系统来收集从标记到颗粒的颗粒或物质发射的荧光，并且具有改善的收集效率，从而保持仪器的分辨率。 光学系统可以包括附接到毛细管的第一收集透镜和布置成与第一收集透镜相邻布置成反射一个或多个波长的荧光的第一反射元件。 光学系统可以包括附接到毛细管的第二收集透镜，以及被配置成反射一个或多个波长的荧光的与第二收集透镜相邻的第二反射元件。

公开(公告)号：US20140026989A1

公开(公告)日：2014-01-30

申请号：US14040777

申请日：2013-09-30

Applicant: EMD Millipore Corporation

Inventor： Brian Hillier ,  Martin Szyk ,  Aaron Burke ,  Joseph Almasian

IPC: F16K31/50

CPC classification number: F16K31/50 ,  F16K1/12 ,  F16K11/22 ,  F16K31/445 ,  F16K31/60 ,  G01N15/0826 ,  Y10T137/0318 ,  Y10T137/7932 ,  Y10T137/794 ,  Y10T137/85938 ,  Y10T137/87885

Abstract: Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position.

Abstract translation: 流体输送装置包括具有通过其内部的至少一部分形成的孔的主体。 包含在孔内的是可移动的柱塞，其移动而不改变主体的轴向尺寸。 身体的第一端包含设计成连接到上游部件的面。 主体的第二端连接到诸如过滤器，管道等的下游部件。当处于关闭位置时，柱塞的第一端与主体的表面对准，其结合形成一个 可蒸发的表面和抵抗环境的无菌屏障到身体内部的其余部分，柱塞和下游部件。 外环形套环可相对于主体旋转并使柱塞在孔内轴向移动，从开放到闭合位置。

公开(公告)号：US20140017779A1

公开(公告)日：2014-01-16

申请号：US14036339

申请日：2013-09-25

Applicant: EMD Millipore Corporation

Inventor： Gael Waiche ,  Monika Kukuczka

IPC: C12Q1/24

CPC classification number: C12Q1/24 ,  C12M33/02 ,  C12M33/14

Abstract: A method for transferring a filter membrane (130) bearing a retentate to a reagent pad (310), in which the membrane is mounted in a support frame (120) having a shoulder (121) and a skirt (122) projecting from the shoulder, the pad being mounted on a cassette (300) of complementary form to said skirt, the skirt being adapted to slide sealingly on the cassette until it comes into abutment formed by the shoulder, the method comprising the steps of sealingly engaging the skirt of the membrane support frame on the cassette, establishing a pressure difference between the cassette and the membrane support frame such that the membrane adopts the shape of a dome pointing towards the pad, while maintaining the pressure difference, applying a force on the frame so as to make the skirt slide on the cassette until contact is established between the end of the dome and the pad, maintaining a force on the frame so as to move it downward until it comes into abutment formed by the shoulder while maintaining the pressure difference.

Abstract translation: 一种用于将带有滞留物的过滤膜（130）转移到试剂垫（310）的方法，其中所述膜安装在具有肩部（121）的支撑框架（120）和从肩部突出的裙部（122） ，所述垫被安装在所述裙部的互补形式的盒（300）上，所述裙部适于在所述盒子上密封地滑动，直到其进入与所述肩部形成的邻接，所述方法包括以下步骤：密封地接合所述裙部的裙部 膜盒支撑框架，在盒和膜支撑框架之间形成压力差，使得膜采取指向垫的圆顶形状，同时保持压力差，对框架施加力，以使 裙子在盒子上滑动，直到在圆顶和垫子的端部之间建立接触，保持框架上的力，以向下移动它，直到它与肩部形成邻接 压力差。

公开(公告)号：US20130233777A1

公开(公告)日：2013-09-12

申请号：US13868372

申请日：2013-04-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： Martin Morrissey ,  Dennis Wong

IPC: B01D35/14

CPC classification number: B01D35/14 ,  B01D61/20 ,  B01D63/084 ,  B01D2313/04 ,  B01D2313/23 ,  B01D2313/44 ,  B01D2313/54 ,  C02F2209/03 ,  G01L7/082 ,  G01N1/10 ,  G01N1/4005 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path.

Abstract translation: 提供了切向流过滤装置，其中衬垫设置在过滤元件和顶部和底部保持器或歧管之间。 内衬包括流动通道，入口和出口以及传感器支架。 衬垫由廉价的材料制成，因此在一次使用后是一次性的，使得它们比处理常规歧管更经济有效。 传感器座可容纳可移动的传感器，并将其与流体路径隔离。

公开(公告)号：US08501120B2

公开(公告)日：2013-08-06

申请号：US13664893

申请日：2012-10-31

Applicant: EMD Millipore Corporation

Inventor： Jiwan Adhikari ,  Aaron Burke

IPC: B01D35/00

CPC classification number: H01Q19/10 ,  G06K7/10178 ,  H01Q1/22 ,  H01Q1/40 ,  H01Q7/00

Abstract: A method and apparatus for providing more reliable wireless communication and power to sensors in electrically challenging bioprocess environments is disclosed. An unconnected antenna is located within the bioprocess environment, preferably in the same plane as the primary powered antenna. This unconnected antenna, also referred to as reflective antenna, enhances and confines the electromagnetic field created by the powered antenna. This reflective antenna is incorporated in or proximate to the devices containing a sensor or communication device. In one embodiment, the reflective antenna is incorporated into the filter housing. In another embodiment, it is incorporated into the filtering element itself. In another embodiment, it is incorporated into or affixed on the disposable bioprocess components, such as bags and tubes.

公开(公告)号：US20130186830A1

公开(公告)日：2013-07-25

申请号：US13739008

申请日：2013-01-11

Applicant: EMD Millipore Corporation

Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

IPC: B01D63/16

CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

公开(公告)号：US20130186275A1

公开(公告)日：2013-07-25

申请号：US13743729

申请日：2013-01-17

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

IPC: B01D53/22

CPC classification number: B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

Abstract: An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

Abstract translation: 公开了一种自主的过滤装置和用于提高过滤器寿命和性能的方法。 过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。 响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。 例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。 作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。 然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。 基于此，控制逻辑可以警告操作者必须更换过滤元件。 或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

公开(公告)号：US20130143259A1

公开(公告)日：2013-06-06

申请号：US13756570

申请日：2013-02-01

Applicant: EMD Millipore Corporation

Inventor： Gael Waiche

IPC: G01N21/76

CPC classification number: G01N21/763 ,  C12Q1/04 ,  G01N21/6428 ,  G01N21/6447 ,  G01N21/645 ,  G01N33/582 ,  G01N2021/6419 ,  G01N2201/0627 ,  G01N2201/0634

Abstract: The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum (53) having a crest (53′) at a predetermined absorption wavelength (λ2) and to release that energy by emitting light with an emission spectrum (54) having a crest (54′) at a predetermined emission wavelength (λ3) distinct from said absorption wavelength (λ2), comprises illuminating means; the spectrum (55) of the excitation light coming from the illuminating means having a crest (55′) at a predetermined excitation wavelength (λ1) with a predetermined difference between the excitation (λ1) and absorption (λ2) wavelengths by virtue of which it is made easy to discriminate the light emitted by said fluorophore agent from that coming from the illuminating means.

Abstract translation: 用于对适于含有由荧光团试剂标记的微生物的载体的微生物分析的装置，所述试剂适于用具有预定吸收波长（λ2）的波峰（53'）的吸收光谱（53）吸收光能，以及 通过发射具有不同于所述吸收波长（λ2）的预定发射波长（λ3）的峰（54'）的发射光谱（54）的光来释放该能量，包括照明装置; 来自照明装置的激发光的光谱（55）具有在预定的激发波长（λ1）处具有在激发（λ1）和吸收（λ2）波长之间的预定差异的波峰（55'），由此， 使得所述荧光团剂发出的光与来自照明装置的光容易。

公开(公告)号：US20130140224A1

公开(公告)日：2013-06-06

申请号：US13754928

申请日：2013-01-31

Applicant: EMD MILLIPORE CORPORATION

Inventor： Sal Giglia ,  Kevin Rautio ,  Mark Blanchard

IPC: B01D69/02

CPC classification number: B01D69/02 ,  B01D65/10 ,  B01D2325/20 ,  G01N15/0826 ,  Y10T29/496 ,  Y10T29/49604 ,  Y10T29/4978

Abstract: Method of reducing performance variability of membrane scaling devices. Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly.

Abstract translation: 降低膜缩放装置的性能变异性的方法。 缩小设备性能不确定度，从而通过指定所有合格制造膜组的窄范围或子集来安装到缩放设备中，从而降低了安全系数。 在某些实施例中，通过确定特定膜所在的性能分布内的哪里以及相应地调整缩放因子来减小可伸缩性因子。