公开(公告)号：US20110216899A1

公开(公告)日：2011-09-08

申请号：US12672214

申请日：2008-08-09

申请人： Yasuyuki Nogami ,  Hidehiro Kato ,  Yoshitaka Morikawa ,  Kenta Nekado

发明人： Yasuyuki Nogami ,  Hidehiro Kato ,  Yoshitaka Morikawa ,  Kenta Nekado

IPC分类号： G06F7/556 ,  H04L9/28

CPC分类号： G06F7/724 ,  G06F7/725 ,  H04L9/3073

摘要： In an arithmetic operation method and an arithmetic operation device arithmetic operations such as exponentiation or scalar multiplication can be performed at high speed. In the case where there exists a plurality of different elements Y and each element Y is represented by tuples in which a plurality of different elements X are combined with an operator, an arithmetic operation method for calculating each element Y by using an electronic computer, associates each element Y with the element X by setting each element X, sets temporary data having an index indicating whether or not each element Y has an identical element X for each element X, and represents each element Y by the temporary data combined with the operator. When there is a combination of temporary data which is common in plurality of elements Y in temporary data contained in each element Y, new temporary data is set by combining the common temporary data and each element Y consisting of each tuple is calculated using the new temporary data.

摘要翻译： 在算术运算方法和算术运算装置中，可以高速进行运算，如乘法运算或标量乘法运算。 在存在多个不同的元素Y的情况下，并且每个元素Y由多个不同元素X与算子组合的元组表示时，算术运算方法用于使用电子计算机来计算每个元素Y， 通过设置每个元素X的每个元素Y与元素X设置具有指示每个元素Y是否具有针对每个元素X的相同元素X的索引的临时数据，并且通过与运算符组合的临时数据来表示每个元素Y。 当存在在每个元素Y中包含的临时数据中的多个元素Y中常见的临时数据的组合时，通过组合公共临时数据来设置新的临时数据，并且使用新的临时数据来计算由每个元组组成的每个元素Y 数据。

公开(公告)号：US20110189237A1

公开(公告)日：2011-08-04

申请号：US13056443

申请日：2009-07-30

申请人： Hiromi Kumon ,  Yasutomo Nasu ,  Yuji Kashiwakura ,  Masami Watanabe ,  Nam-ho Huh ,  Masakiyo Sakaguchi

发明人： Hiromi Kumon ,  Yasutomo Nasu ,  Yuji Kashiwakura ,  Masami Watanabe ,  Nam-ho Huh ,  Masakiyo Sakaguchi

IPC分类号： A61K31/7088 ,  A61P35/00 ,  A61P37/04

CPC分类号： C07K14/47 ,  A61K35/13 ,  A61K38/00 ,  C12N2799/022

摘要： According to the present invention, a method for treating malignant mesothelioma using REIC/Dkk-3 and a therapeutic agent for malignant mesothelioma comprising REIC/Dkk-3 are provided. A mesothelioma therapeutic agent is provided, comprising the following REIC/Dkk-3 DNA or a vector comprising the DNA as an active ingredient: (a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to a DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and IL-7 production-accelerating activity in cells.

摘要翻译： 根据本发明，提供了使用REIC / Dkk-3治疗恶性间皮瘤的方法和包含REIC / Dkk-3的恶性间皮瘤治疗剂。 提供间皮瘤治疗剂，其包含以下REIC / Dkk-3 DNA或包含该DNA作为活性成分的载体：（a）由SEQ ID NO：1所示核苷酸序列组成的DNA; 或（b）在严格条件下与由与SEQ ID NO：1所示核苷酸序列互补的核苷酸序列组成的DNA杂交并编码细胞中具有凋亡诱导活性和IL-7生产加速活性的蛋白质的DNA。

公开(公告)号：US20110172445A1

公开(公告)日：2011-07-14

申请号：US13001676

申请日：2009-06-26

申请人： Yusuke Wataya ,  Hye-Sook Kim ,  Akiko Hiramoto ,  Akira Sato ,  Nobuo Ota ,  Takashi Kumagai ,  Rieko Shimogawara ,  Toshie Taniguchi

发明人： Yusuke Wataya ,  Hye-Sook Kim ,  Akiko Hiramoto ,  Akira Sato ,  Nobuo Ota ,  Takashi Kumagai ,  Rieko Shimogawara ,  Toshie Taniguchi

IPC分类号： C07D323/00

CPC分类号： C07D323/00 ,  A61K31/357 ,  C07D325/00 ,  Y02A50/423

摘要： An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.

摘要翻译： 本发明的目的是提供一种新的抗血吸虫药，更具体地说，提供一种能够在体内抑制血吸虫生长的新型药物，以防止在感染情况下由于血吸虫卵产生的肝功能障碍的发展 血吸虫 新型抗血吸虫药包括作为活性成分的过氧化物衍生物。 具体地说，新型抗血吸虫药包括作为活性成分的通式（I）表示的过氧化物衍生物：其中C表示可被取代的脂环族烃环基，n表示1〜6的整数。

公开(公告)号：US20110169057A1

公开(公告)日：2011-07-14

申请号：US13063600

申请日：2009-06-30

申请人： Keiji Tsukada

发明人： Keiji Tsukada

IPC分类号： H01L27/088

CPC分类号： G01N27/4141 ,  G01N27/4148

摘要： [Object] To provide a gas sensor having a self-diagnostic function with a simplified structure.[Means of Realizing the Object] A gas sensor (30) includes two field-effect transistors and gate electrodes on gate insulation films (24) of the two field-effect transistors to detect gas using the gate electrodes. The gas sensor (30) includes a first gate electrode (5), a second gate electrode (6), and voltage applying means. The first gate electrode (5) is provided on one of the field-effect transistors. The second gate electrode (6) is provided on another one of the field-effect transistors. The voltage applying means is for, with the first gate electrode (5) and the second gate electrode (6) coupled to one another by wiring, applying thereto one of a direct-current voltage and an alternating-current voltage having a same potential or a constant voltage difference. The first gate electrode (5) and the second gate electrode (6) are made of different metals. The one field-effect transistor and the other field-effect transistor have approximately the same structures.

摘要翻译： 提供具有简化结构的自诊断功能的气体传感器。 [实现对象的手段]气体传感器（30）在两个场效应晶体管的栅极绝缘膜（24）上包括两个场效应晶体管和栅电极，以使用栅电极检测气体。 气体传感器（30）包括第一栅电极（5），第二栅电极（6）和电压施加装置。 第一栅电极（5）设置在场效应晶体管中的一个上。 第二栅电极（6）设置在另一个场效应晶体管上。 电压施加装置用于通过布线将第一栅电极（5）和第二栅电极（6）彼此耦合，向其施加具有相同电位的直流电压和交流电压之一或 恒压差。 第一栅电极（5）和第二栅电极（6）由不同的金属制成。 一个场效应晶体管和另一个场效应晶体管具有大致相同的结构。

公开(公告)号：US20100167411A1

公开(公告)日：2010-07-01

申请号：US12594149

申请日：2008-03-04

申请人： Yoshinori Moriyama ,  Hiroshi Omote ,  Keisuke Sawada

发明人： Yoshinori Moriyama ,  Hiroshi Omote ,  Keisuke Sawada

IPC分类号： G01N33/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C07K14/435 ,  C07K16/18 ,  C07H21/02 ,  C07H19/20

CPC分类号： G01N33/6872 ,  C07K14/47 ,  C07K16/18 ,  C12N15/1138 ,  C12N2310/14 ,  G01N2500/04 ,  G01N2800/224 ,  G01N2800/2842 ,  Y10T436/143333

摘要： It is an object of the invention to isolate a transporter responsible for ATP transport and a gene encoding the transporter. It is another object of the invention to provide a method for the screening of a medicament for treating and/or regulating pain in central nerves, blood coagulation by platelet-derived ATP, or the like, the method employing such a transporter. According to the invention, a transporter responsible for ATP transport and a gene encoding the transporter were isolated. Furthermore, there is provided a method for the screening of a medicament for treating and/or regulating pain in central nerves, blood coagulation by platelet-derived ATP, or the like, the method employing such a transporter.

摘要翻译： 本发明的目的是分离负责ATP运输的转运蛋白和编码转运蛋白的基因。 本发明的另一个目的是提供一种用于筛选用于治疗和/或调节中枢神经疼痛，血小板衍生的ATP血液凝固等的药物的方法，该方法使用这种转运蛋白。 根据本发明，分离负责ATP运输的转运蛋白和编码转运蛋白的基因。 此外，提供了筛选用于治疗和/或调节中枢神经疼痛，血小板衍生的ATP血液凝固等的药物的方法，该方法使用这种转运蛋白。

公开(公告)号：US20100069443A1

公开(公告)日：2010-03-18

申请号：US12440519

申请日：2007-09-07

申请人： Hiroki KAKUTA ,  Kenji SASAKI ,  Hiroyuki ODA ,  Xiaoxia ZHENG ,  Shun HARADA

发明人： Hiroki KAKUTA ,  Kenji SASAKI ,  Hiroyuki ODA ,  Xiaoxia ZHENG ,  Shun HARADA

IPC分类号： A61K31/44 ,  C07D213/72 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C12N5/00 ,  C12N9/99

CPC分类号： A61K31/167 ,  A61K31/44 ,  C07C233/80 ,  C07C237/40 ,  C07D213/75

摘要： This invention provides a novel COX-1-selective inhibitor. This invention relates to a novel compound represented by the formula below or a salt thereof. This invention also relates to an analgesic agent, an antiinflammatory agent, an antitumor agent, an antiplatelet aggregation agent, and a cyclooxygenase-1-selective inhibitor comprising, as an active ingredient, such compound or salt thereof.

摘要翻译： 本发明提供了一种新型的COX-1选择性抑制剂。 本发明涉及由下式表示的新化合物或其盐。 本发明还涉及一种止痛剂，抗炎剂，抗肿瘤剂，抗血小板聚集剂和环加氧酶-1-选择性抑制剂，其包含作为活性成分的这种化合物或其盐。

公开(公告)号：US20090246135A1

公开(公告)日：2009-10-01

申请号：US12310019

申请日：2007-07-31

申请人： Yoshirou Kawahara

发明人： Yoshirou Kawahara

IPC分类号： A61K49/00

CPC分类号： A61K49/006 ,  A61B1/00 ,  A61B1/273 ,  A61B5/0059 ,  A61B5/42

摘要： A diagnostic agent for being sprinkled to the inner wall of a gastrointestine in endoscopic observation, comprising an acidic aqueous solution of pH 1 to 5 containing a colorant and also containing at least one acid selected from the group consisting of a carboxylic acid, hydrochloric acid, sulfuric acid and phosphoric acid. By sprinkling such a diagnostic agent to the inner wall of a gastrointestine in endoscopic observation, it is possible to clearly observe a lesion which is difficult to be determined. In particular, it is suitable for observing lesions having cancer cells in the stomach or the Barrett's esophagus.

摘要翻译： 一种在内窥镜观察中喷洒到胃肠道内壁的诊断剂，其包含含有着色剂的pH1〜5的酸性水溶液，还含有选自羧酸，盐酸， 硫酸和磷酸。 通过在内窥镜观察中将这样的诊断剂喷洒到胃肠道的内壁，可以清楚地观察难以确定的病变。 特别地，适合于观察胃或Barrett食道中具有癌细胞的病变。

公开(公告)号：US20090240026A1

公开(公告)日：2009-09-24

申请号：US12306784

申请日：2007-07-03

申请人： Masumi Taki ,  Masahiko Sisido

发明人： Masumi Taki ,  Masahiko Sisido

IPC分类号： C07K2/00 ,  C07D219/00

CPC分类号： C07D219/06 ,  C09K11/06 ,  C09K2211/1029

摘要： An object of the present invention is to provide a novel fluorescent amino acid derivative which can be synthesized by simple steps, can be excited particularly by a blue laser ray region of visible light, and has an improved light stability. Another object is to provide a production method of the fluorescent amino acid derivative. These objects can be achieved by a fluorescent amino acid derivative which is an acridone derivative substituted with an amino acid to comprise an electrophilic substituent group between the amino acid and the acridone derivative. Instead of a conventional strategy that aminophenylalanine is used as a starting material to form a fluorescent group through a coupling reaction and an intramolecular cyclization reaction, a fluorescent acridone derivative is used as a starting material to furnish the material to a reactive group by a position-specific electrophilic substitution reaction, and then the acridone derivative having the reactive group is allowed to couple with an amino acid derivative.

摘要翻译： 本发明的目的是提供可以通过简单的步骤合成的新的荧光氨基酸衍生物，特别可以通过可见光的蓝色激光射线区域被激发，并且具有改善的光稳定性。 另一个目的是提供荧光氨基酸衍生物的制备方法。 这些目的可以通过荧光氨基酸衍生物来实现，其是由氨基酸取代的吖啶酮衍生物，其在氨基酸和吖啶酮衍生物之间包含亲电取代基。 代替使用氨基苯丙氨酸作为通过偶联反应和分子内环化反应形成荧光基团的起始材料的常规策略，使用荧光吖啶酮衍生物作为原料，通过位置 - 取代基将该材料提供给反应性基团， 特异性亲电取代反应，然后使具有反应性基团的吖啶酮衍生物与氨基酸衍生物偶联。

公开(公告)号：US20090220976A1

公开(公告)日：2009-09-03

申请号：US12304936

申请日：2007-06-15

申请人： Takashi Oka ,  Takami Kondo ,  Tadashi Yoshino ,  Mamoru Ouchida

发明人： Takashi Oka ,  Takami Kondo ,  Tadashi Yoshino ,  Mamoru Ouchida

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2800/56

摘要： An object of the present invention is to provide a test method for MALT lymphomas for providing genetic diagnosis data which can be used for the diagnosis of MALT lymphomas, identification of disease type, and prediction of progression of pathological conditions and onset thereof and a kit for implementing the method. At least two types of tumor-suppressor genes or cancer-related genes are selected, in particular, at least two types of genes are selected from a gene group consisting of 11 genes in a sample, and the expression levels or the gene expression regulation status of the selected genes are investigated. Early detection and diagnosis with high sensitivity and accuracy can be conducted by quantitatively determining the genetic product and preparing the expression profiles of the gene group on the basis of the results, or by detecting methylation frequencies to analyze the expression regulation.

摘要翻译： 本发明的目的是提供一种用于提供可用于诊断MALT淋巴瘤的遗传诊断数据的MALT淋巴瘤的测试方法，疾病类型的鉴定以及病理状态和发作进展的预测以及用于 实施该方法。 选择至少两种类型的肿瘤抑制基因或癌症相关基因，特别是至少两种类型的基因选自样品中由11个基因组成的基因组，表达水平或基因表达调控状态 的所选基因进行了研究。 可以通过定量确定基因产物并根据结果制备基因组的表达谱，或通过检测甲基化频率来分析表达调控，进行高灵敏度和准确度的早期检测和诊断。

公开(公告)号：US07407984B2

公开(公告)日：2008-08-05

申请号：US10507640

申请日：2003-03-11

申请人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

发明人： Yusuke Wataya ,  Hye-Sook Kim ,  Masatomo Nojima

IPC分类号： A61K31/357

CPC分类号： A61K31/357 ,  C07D323/00 ,  Y02A50/411

摘要： The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents any one of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].

摘要翻译： 本发明提供具有优异的抗疟活性的抗疟药，其副作用小，特别是对耐药性疟疾寄生虫具有显着的抗疟活性，并且能够增加不仅对包括橄榄油在内的有机溶剂的溶解性， 水，因此不仅可用作口服药物，也可用作可注射溶液。 本发明的抗疟剂含有下述通式（I）表示的化合物[式中，Z表示未取代或任意取代的脂环族烃基，R 0表示水溶性官能团，m 表示0至6的整数中的任何一个，n表示0至10的整数中的任何一个。