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    Multiple carousel cartridge-based dispensing system and method
    42.
    发明授权
    Multiple carousel cartridge-based dispensing system and method 有权

    公开(公告)号：US11385249B2

    公开(公告)日：2022-07-12

    申请号：US17298831

    申请日：2019-12-03

    Applicant: BD KIESTRA B.V.

    Inventor： Michael John Wilsher ,  Simon Jowett ,  Roy Norman Gladwin ,  Mark William Horobin ,  Kenneth Charles Smith ,  Duncan Stevenson ,  Timothy Roy Hansen ,  Johannes Wijnandus Thiecke

    IPC: G01N35/02 ,  G01N35/04 ,  G01N35/10

    Abstract: An improved system and method for the selection and dispensing of reagents onto a target testing medium in an automated laboratory environment. The system utilizes multiple carousels rotatably-mounted upon a central turntable. The position of the central turntable, as well as the rotation of each carousel is controlled by a microprocessor-based control system. Multiple dispensers, each capable of storing and dispensing a particular reagent, are mounted about the circumference of each carousel. This configuration provides much higher reagent density than previously available. The testing medium is positioned at one or more loading stations. The control system directs the central turntable to a position from which a selected one of the carousels can be rotated so as to position a selected dispenser above the testing medium. The selected dispenser is then actuated to release a predetermined reagent onto the testing medium. The system can be configured so that multiple reagents can be dispensed, each from an associated dispenser, onto a single or multiple testing mediums. Each of these actuated dispensers being positioned over the targeted testing medium(s) positioned at one or more loading stations.

    SYSTEMS AND METHODS FOR CENTERING A CIRCULAR OBJECT
    44.
    发明申请
    SYSTEMS AND METHODS FOR CENTERING A CIRCULAR OBJECT 有权

    公开(公告)号：US20210269759A1

    公开(公告)日：2021-09-02

    申请号：US17259408

    申请日：2019-07-10

    Applicant: BD KIESTRA B.V.

    Inventor： Wouter Kuiper ,  Harm W. van der Dong ,  Jan Bart Van Der Vijver ,  Martijn Kleefstra

    IPC: C12M1/00 ,  C12M1/22 ,  B01L9/00

    Abstract: The present disclosure describes systems and methods for centering a circular object, such as a petri dish, between a plurality of pins. For example, in one embodiment, a method comprises placing a circular object on a rotatable platform surrounded by three moveable pins. In order to roughly center the circular object, the method further comprises moving, for a first time, all of the pins toward the circular object until at least two out of the three pins are touching the circular object. In order to more accurately center the circular object, the method further comprises: moving all of the pins away from the circular object so that it can be rotated without substantial inference; rotating the platform approximately 60 degrees, wherein rotating the platform causes the circular object to also rotate by approximately 60 degrees; and moving, for a second time, all of the pins toward the circular object.

    System and method for incubation and reading of biological cultures
    45.
    发明授权
    System and method for incubation and reading of biological cultures 有权

    公开(公告)号：US11041871B2

    公开(公告)日：2021-06-22

    申请号：US14687400

    申请日：2015-04-15

    Applicant: BD Kiestra B.V.

    Inventor： Martijn Kleefstra ,  Martijn Xander Berntsen ,  Jan Bart Van Der Vijver ,  Tsjerk Nauta ,  Andrej Girgenson

    IPC: C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  G01N35/04 ,  G01N35/00 ,  C12M1/36 ,  C12M3/00 ,  G01N35/02

    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.

    AUTOMATED SELECTION OF MICROORGANISMS AND IDENTIFICATION USING MALDI
    48.
    发明申请
    AUTOMATED SELECTION OF MICROORGANISMS AND IDENTIFICATION USING MALDI 审中-公开

    公开(公告)号：US20180364264A1

    公开(公告)日：2018-12-20

    申请号：US16058414

    申请日：2018-08-08

    Applicant: BD KIESTRA B.V.

    Inventor： Jetze Botma ,  Martijn Kleefstra ,  Tino Walter Van der Zee

    IPC: G01N35/00 ,  H01J49/16 ,  G01N35/10 ,  C12M1/26 ,  C12M1/22 ,  C12Q3/00 ,  C12M1/36 ,  G01N1/04

    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.

    Automated selection of microorganisms and identification using MALDI
    49.
    发明授权
    Automated selection of microorganisms and identification using MALDI 有权

    公开(公告)号：US10073105B2

    公开(公告)日：2018-09-11

    申请号：US15663540

    申请日：2017-07-28

    Applicant: BD KIESTRA B.V

    Inventor： Jetze Botma ,  Martijn Kleefstra ,  Tino Walter Van der Zee

    IPC: C12M1/00 ,  G01N35/00 ,  H01J49/16 ,  C12M1/36 ,  C12M1/22 ,  G01N35/10 ,  G01N1/04

    CPC classification number: G01N35/00029 ,  C12M23/10 ,  C12M33/04 ,  C12M41/48 ,  C12Q3/00 ,  G01N35/10 ,  G01N2001/045 ,  G01N2035/1032 ,  H01J49/164

    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool.

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