公开(公告)号：US20090232865A1

公开(公告)日：2009-09-17

申请号：US12409129

申请日：2009-03-23

Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Vidya Nayak ,  Lothar Kleiner

Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Vidya Nayak ,  Lothar Kleiner

IPC: A61K9/00 ,  C08G69/44 ,  A61K47/34 ,  A61K31/337 ,  A61K31/56 ,  A61K38/44 ,  A61K31/445 ,  A61K31/4353 ,  A61K39/395 ,  A61P9/00 ,  A61F2/82

CPC classification number: C08G69/48 ,  A61L27/34 ,  A61L31/041 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08G69/44 ,  Y10T428/31551 ,  Y10T428/31725 ,  C08L77/12

Abstract: This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.

Abstract translation: 本发明涉及包含灭活的末端氨基和羧基的聚（酯酰胺）（PEA），合成灭活的PEAs的方法及其用于治疗血管疾病的用途。

公开(公告)号：US20080175886A1

公开(公告)日：2008-07-24

申请号：US12056216

申请日：2008-03-26

Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

IPC: A61F2/00 ,  A61K31/436

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

Abstract: Provided herein is a bioabsorbable implantable device comprising a bioactive agent and a poly(ester amide) (PEA) polymer blend.

Abstract translation: 本文提供了包含生物活性剂和聚（酯酰胺）（PEA）（PEA）聚合物共混物的生物可吸收可植入装置。

公开(公告)号：US20080124372A1

公开(公告)日：2008-05-29

申请号：US11448956

申请日：2006-06-06

Applicant: Syed F. A. Hossainy ,  Fuh-Wei Tang ,  Lothar Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter Roorda ,  Stephen Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

Inventor： Syed F. A. Hossainy ,  Fuh-Wei Tang ,  Lothar Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter Roorda ,  Stephen Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61F2/06 ,  B05D3/00 ,  A61K47/48 ,  A61K31/436 ,  A61K31/337 ,  A61K31/46 ,  A61P9/00

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：US07368126B2

公开(公告)日：2008-05-06

申请号：US10701939

申请日：2003-11-04

Applicant: Guohua Chen ,  Paul Houston ,  Roy Bannister ,  Teresa Kameda ,  David Priebe ,  Lothar Kleiner

Inventor： Guohua Chen ,  Paul Houston ,  Roy Bannister ,  Teresa Kameda ,  David Priebe ,  Lothar Kleiner

IPC: A61F2/00

CPC classification number: A61K9/0024 ,  A61K9/14 ,  A61K9/143 ,  A61K9/145 ,  A61K9/1611 ,  A61K9/1688 ,  A61K9/2013 ,  A61K9/204 ,  A61K47/34

Abstract: Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract translation: 描述了用于系统地或局部施用受试者的有益药物的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到期望的位置并且可以在长时间内提供有益药物的受控释放。 组合物包括生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

公开(公告)号：US07365133B2

公开(公告)日：2008-04-29

申请号：US11638298

申请日：2006-12-12

Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

IPC: A61L27/34 ,  A61L29/08 ,  C08L77/12

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and coatings and medical devices formed of the blend.

Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和由共混物形成的涂层和医疗装置。

公开(公告)号：US20080063626A1

公开(公告)日：2008-03-13

申请号：US11940085

申请日：2007-11-14

Applicant: Zhongli Ding ,  Lothar Kleiner

Inventor： Zhongli Ding ,  Lothar Kleiner

IPC: A61K31/135 ,  A61K31/20 ,  A61K31/40 ,  A61K31/44 ,  A61K31/495 ,  A61K31/51 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/56 ,  A61K31/70 ,  A61K38/00 ,  A61K38/21 ,  A61K39/395 ,  A61K45/00 ,  A61K47/00 ,  A61K47/30 ,  A61P43/00

CPC classification number: A61K47/12 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1694 ,  A61K31/355 ,  A61K47/32 ,  A61K47/34

Abstract: This invention relates to compositions and methods for preventing oxidation of beneficial agents that comprise at least one beneficial agent and an excipient, wherein the excipient has been irradiated and annealed.

Abstract translation: 本发明涉及用于防止包含至少一种有益剂和赋形剂的有益剂的氧化的组合物和方法，其中所述赋形剂已被照射和退火。

公开(公告)号：US20080038310A1

公开(公告)日：2008-02-14

申请号：US11803031

申请日：2007-05-10

Applicant: Syed Hossainy ,  Yiwen Tang ,  Lothar Kleiner

Inventor： Syed Hossainy ,  Yiwen Tang ,  Lothar Kleiner

IPC: A61F2/06 ,  A61F2/04 ,  A61K31/337 ,  A61K31/4353 ,  A61K31/445 ,  A61K31/496 ,  A61K31/56 ,  A61K38/43 ,  A61K47/42 ,  A61P13/02 ,  A61P9/00 ,  A61P9/10

CPC classification number: A61L31/10 ,  A61K38/08 ,  A61K38/39 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/047 ,  A61L31/16 ,  A61L2300/25 ,  A61L2420/02 ,  B05D3/007 ,  C07K14/001 ,  C08H1/00 ,  Y10T428/3154 ,  Y10T428/31909

Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.

Abstract translation: 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。

公开(公告)号：US20070258903A1

公开(公告)日：2007-11-08

申请号：US11416860

申请日：2006-05-02

Applicant: Lothar Kleiner ,  Syed Hossainy ,  Irina Astafieva ,  Stephen Pacetti ,  Thierry Glauser ,  Jessica DesNoyer ,  Florian Ludwig

Inventor： Lothar Kleiner ,  Syed Hossainy ,  Irina Astafieva ,  Stephen Pacetti ,  Thierry Glauser ,  Jessica DesNoyer ,  Florian Ludwig

IPC: A61K39/00 ,  A61K49/10

CPC classification number: A61K9/0019 ,  A61K9/143 ,  A61K9/1611 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/602

Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.

Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。

公开(公告)号：US20070243256A1

公开(公告)日：2007-10-18

申请号：US11405976

申请日：2006-04-17

Applicant: Lothar Kleiner ,  Syed Hossainy ,  Stephen Pacetti ,  Jessica DesNoyer

Inventor： Lothar Kleiner ,  Syed Hossainy ,  Stephen Pacetti ,  Jessica DesNoyer

IPC: A61K31/4745 ,  A61K31/337 ,  C08G69/48 ,  C08G63/91 ,  A61K9/14

CPC classification number: A61K47/48207 ,  A61K9/0024 ,  A61K9/08 ,  A61K9/10 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K47/34 ,  A61K47/593 ,  A61K47/595 ,  A61K47/60 ,  C08L77/12 ,  C08L2205/02 ,  C08L2666/20

Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.

Abstract translation: 本文描述了由特定类型的聚（酯酰胺）（PEA），治疗剂和水混溶性溶剂形成的治疗剂递送系统。 通过将由PEA聚合物，治疗剂和水混溶性溶剂形成的治疗剂递送系统递送到生理环境来递送治疗剂递送系统的方法，并分离治疗剂递送系统的相以形成膜 也描述了在生理环境中含有治疗剂的聚合物。 另外公开了一种试剂盒，其包括注射器内的注射器和治疗剂递送系统。

公开(公告)号：US20070202147A1

公开(公告)日：2007-08-30

申请号：US11365549

申请日：2006-02-28

Applicant: Lothar Kleiner ,  Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy

Inventor： Lothar Kleiner ,  Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy

IPC: A61F2/02 ,  A61K38/44 ,  A61K31/56 ,  A61K31/4745 ,  A61K31/337

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02

Abstract: A method of forming a coating on a medical device having a controlled morphology is described.

Abstract translation: 描述了在具有受控形态的医疗装置上形成涂层的方法。