摘要:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
摘要:
Novel imidazole compounds of the general formula are disclosed, wherein R1 and R2 comprise heteroaryl groups. These compounds and compositions containing them are useful in methods to treat Raf kinase-mediated disorders such as cancer.
摘要:
In accordance with embodiments of the present disclosure, a method for demand aggregation is provided. The method may include routing demands in a ring network such that a length for each routed demand does not exceed a route length maximum, and a load imbalance at each node in the ring network is minimized. The method may also include maximizing optical line card sharing by assigning routed demands sharing common ends to the same wavelength.
摘要:
According to particular embodiments, determining disjoint paths includes receiving a graph representing a network comprising nodes and links. The graph is transformed such that the number of intermediate nodes of a path indicates the number of regenerators for the path. A set of seed paths from a source node to a destination node of the transformed graph is generated. For each seed path, a shortest path from the source node to the destination node is determined to yield one or more pairs of disjoint paths from the source node to the destination node. An optimized pair of disjoint paths is selected, where the optimized pair of disjoint paths has an optimized number of regenerators.
摘要:
The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one primer. The asymmetric PCR amplification provided includes the steps: 1) preparative denaturing; 2) repetitiously denaturing, primers annealing, extending cycles as the first stage of PCR amplification; 3) repetitiously denaturing, primer extending cycles as the second stage of PCR amplification, wherein an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one PCR primer of each pair in extension. With the asymmetric PCR amplification of the invention, high throughput of single-stranded products can be obtained, single PCR amplification or multiple PCR amplification can be carried out. And the method can be widely used in detection of nucleic acids.
摘要:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bmx, b-RAF, c-RAF, c-SRC, KDR, CSK, FGFR3, JAK2, Lck, Met, PKCα, SAPK2α, Tie2, TrkB and P70S6K kinases.
摘要:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ΣΓK, Ttε2, Λχκ, ΘNK2α2, MKK4, c-RAF, MKK6, SAPK2α and SAPK2β kinases.
摘要:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.
摘要:
An optical network analysis tool includes a computer-readable storage medium having computer-readable instructions stored thereon. The computer-readable instructions are executable by a computing device to perform operations. The operations include generating a simulated network that models an optical network. The simulated network includes regenerator candidate sites. The operations may also include conducting an analysis of the optical network. The analysis includes introducing a multiple signals transmitted between source/destination pairs and recording a number of times each of the regenerator candidate sites are selected as a regenerator site while applying each of a set of data traffic conditions in the simulated network. The operations may also include statistically analyzing the number of times each of the regenerator candidate sites is selected to generate statistically analyzed information and presenting the statistically analyzed information.
摘要:
In accordance with some embodiments of the present disclosure a method for shared mesh protection in an optical transport network comprises provisioning a route for each of a plurality of working demands through the optical transport network. The method further comprises provisioning a route for backup demands corresponding to each of the plurality of working demands. The method additionally comprises packing into a single optical data unit a first backup demand corresponding to a first of the plurality of working demands and a second backup demand corresponding to a second of the plurality of working demands, wherein the first and second of the plurality of working demands share at least one common link in the optical transport network. The method also comprises unpacking the first and second backup demands from the optical data unit.