公开(公告)号：US10806904B2

公开(公告)日：2020-10-20

申请号：US15467554

申请日：2017-03-23

Applicant: Surmodics, Inc.

Inventor： Bruce M. Jelle ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Nathan A. Lockwood

IPC: A61M25/06 ,  A61M25/00 ,  A61M39/06

Abstract: Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

公开(公告)号：US20200171531A1

公开(公告)日：2020-06-04

申请号：US16696234

申请日：2019-11-26

Applicant: Surmodics, Inc.

Inventor： Ralph A. Chappa ,  Michael Militello

IPC: B05C17/02 ,  B05C17/03

Abstract: Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.

公开(公告)号：US20190300474A1

公开(公告)日：2019-10-03

申请号：US16414315

申请日：2019-05-16

Applicant: Surmodics, Inc.

Inventor： Aleksey V. Kurdyumov

IPC: C07C275/38 ,  C07C271/28

Abstract: Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.

公开(公告)号：US10342898B2

公开(公告)日：2019-07-09

申请号：US15375442

申请日：2016-12-12

Applicant: Surmodics, Inc.

Inventor： David E. Babcock ,  Joram Slager ,  Robert W. Hergenrother

IPC: B05D7/02 ,  B05D5/08 ,  B05D1/18 ,  A61L29/14 ,  A61L29/08 ,  B05D3/00 ,  B05D3/06 ,  B05D7/00

Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

公开(公告)号：US10124088B2

公开(公告)日：2018-11-13

申请号：US14860128

申请日：2015-09-21

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

IPC: A61L29/14 ,  A61L29/08 ,  A61L29/04 ,  C08J3/20 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

公开(公告)号：US20180303803A1

公开(公告)日：2018-10-25

申请号：US15959589

申请日：2018-04-23

Applicant: Surmodics, Inc.

Inventor： Joram Slager

IPC: A61K31/436 ,  A61K9/16 ,  A61K9/14 ,  A61L29/16 ,  A61L29/08 ,  A61K9/51 ,  A61K9/19 ,  A61K9/107 ,  A61K9/00

CPC classification number: A61K31/436 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61L29/085 ,  A61L29/16 ,  Y02A50/402 ,  Y02A50/478 ,  Y10T428/2982

Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

公开(公告)号：US09795720B2

公开(公告)日：2017-10-24

申请号：US15211833

申请日：2016-07-15

Applicant: Surmodics, Inc.

Inventor： Ralph A. Chappa ,  Kimberly K. M. Lindsoe

IPC: A61K47/32 ,  A61K31/56 ,  A61L31/16 ,  A61K6/00 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14

CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

Abstract: Aspects herein relate to coatings with crystallized active agent(s) and related methods. A method for coating a medical device herein includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device.

公开(公告)号：US20170281831A1

公开(公告)日：2017-10-05

申请号：US15474601

申请日：2017-03-30

Applicant: Surmodics, Inc.

Inventor： Mike Militello

IPC: A61L29/08 ,  A61L29/14

CPC classification number: A61L29/085 ,  A61L29/14 ,  A61L2400/10 ,  A61L2420/02 ,  C08L33/08 ,  C08L33/26

Abstract: Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.

公开(公告)号：US09737639B2

公开(公告)日：2017-08-22

申请号：US15165650

申请日：2016-05-26

Applicant: SurModics, Inc.

Inventor： David E. Babcock

IPC: A61L29/08 ,  A61L29/14 ,  A61L27/34 ,  A61L31/10

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/06 ,  A61L2420/08 ,  C08L39/06

Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; anda first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

公开(公告)号：US20170224876A1

公开(公告)日：2017-08-10

申请号：US15502345

申请日：2015-08-06

Applicant: SURMODICS, INC.

Inventor： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

IPC: A61L29/08 ,  A61L29/16 ,  G01N33/543 ,  A61L29/06

CPC classification number: A61L29/085 ,  A61K31/7024 ,  A61L27/34 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  G01N33/54393

Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological mo lecule.