Abstract:
The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
Abstract:
A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: —(NCN—R1)— wherein R1 represents a divalent organic group, with an aromatic diamine represented by the general formula: H2N—R2—NH2 wherein R2 represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.
Abstract:
The present invention provides an insulating material for the enameled wire of a motor of a refrigeration compressor using hydrofluorocarbons as the refrigerant and, as the refrigerating machine oil, a synthetic lubricating oil having at least one ester bond in a molecule such as ester-modified polyoxyalkylene glycol type, ester-modified ether type or ester type, which insulating material contains a compound having at least one carbodiimide group.This insulating material for the enameled wire of a motor of a refrigeration compressor, which is free from the above-mentioned problems of the prior art, which can prevent the surface deterioration or peeling (blister or cracking) etc. seen in the conventional insulating material used for covering the enameled wire (e.g. magnet wire) of a refrigeration compressor, caused by a mixture of the hydrofluorocarbons and the synthetic lubricating oil both used in the compressor, which invites neither insulation breakdown nor reduction in insulation and has improved resistances to said substitute flon and said synthetic lubricating oil, and which further can impart deterioration resistance to the synthetic lubricating oil.
Abstract:
The present invention provides an insulating film for use in the motor of a refrigeration compressor using a substitute flon and a refrigerating machine oil in particular combination, which film is obtained by adding to a base film, or coating on the surface of a base film, a compound having at least one carbodiimide group, or, which film is made essentially of a compound having at least one carbodiimide group, represented by the following formula (1): ##STR1## or the following formula (2): ##STR2## or the following formula (3): ##STR3## or the following formula (4): ##STR4## This insulating film can eliminate the problems of the prior art, has excellent resistance to hydrolysis and forms no sludge, resultantly can prevent reduction in insulating property, and further has deterioration resistance to refrigerating machine oil.
Abstract:
The invention provides cosmetics or dermatological compositions comprising plant extract or whey extract having an action to potentiate laminin 5 productivity in the epidermal cells. They have mainly the action and efficacy to prevent or improve aging in the skin.
Abstract:
A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.
Abstract:
Disclosed is an anti-wrinkle agent for ameliorating a wrinkle (particularly a fine wrinkle) developed when the barrier function is decreased by dryness and the like. Also disclosed is an ADAM inhibitor. The anti-wrinkle agent or the ADAM inhibitor comprises an alkyl glucoside represented by the general formula: (1) [wherein R represents a linear or branched alkyl group having 1 to 18 carbon atoms] or a salt thereof.
Abstract:
A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.
Abstract:
A plaster including a backing layer and a drug layer laminated on the backing layer, where the drug layer contains an adhesive base and at least one compound selected from the group consisting of citalopram and pharmaceutically acceptable salts thereof, an abundance ratio of the S form being greater than an abundance ratio of the R form.
Abstract:
A Bisoprolol patch, wherein the skin penetration rate of Bisoprolol after 24 hours is 15 to 60% of the maximum skin penetration rate thereof, shows a little difference between the maximum level of the concentration in blood and the minimum level thereof in repeated administration and, therefore, scarcely exhibits side effects. Moreover, it achieves the quick development of the drug effect owing to the stabilization of the concentration in blood within a short time.