公开(公告)号：US20070191624A1

公开(公告)日：2007-08-16

申请号：US10591829

申请日：2005-03-08

申请人： Shu Kobayashi ,  Ryo Akiyama ,  Nobuyuki Kawai ,  Masahiro Takeuchi

发明人： Shu Kobayashi ,  Ryo Akiyama ,  Nobuyuki Kawai ,  Masahiro Takeuchi

IPC分类号： C07C253/10 ,  C07C209/20 ,  B01J31/00

CPC分类号： C07C67/347 ,  B01J13/14 ,  B01J31/165 ,  B01J31/2239 ,  B01J31/226 ,  B01J31/4015 ,  B01J2231/326 ,  B01J2231/346 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/44 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/35 ,  B01J2531/37 ,  B01J2531/38 ,  B01J2531/842 ,  B01J2540/22 ,  C07C45/46 ,  C07C45/511 ,  C07C45/72 ,  C07C45/73 ,  C07C49/245 ,  C07C49/573 ,  C07C49/76 ,  C07C49/83 ,  C07C67/00 ,  C07C227/12 ,  C07C327/22 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  Y02P20/584 ,  C07C69/732 ,  C07C69/738 ,  C07C69/757 ,  C07C229/34

摘要： The objective is to incarcerate a Lewis acid metal in a polymer and to make this catalyst recoverable while maintaining its function as a Lewis acid metal catalyst. The present invention is a polymer-incarcerated Lewis acid metal catalyst in which a Lewis acid metal is incarcerated in a crosslinked polymer and the crosslinked polymer is crosslinked using the crosslinking groups contained in a crosslinkable polymer. The polymer incarcerated Lewis acid metal catalyst is characterized by the crosslinkable polymer containing at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups, and the hydrophobic substituents contain aromatic substituents. This crosslinkable polymer preferably comprises at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups and a monomer unit containing hydrophobic substituents. This catalyst can be obtained by subjecting a polymer micelle incarcerated Lewis acid metal obtained by mixing an organic solution containing a crosslinkable polymer and a Lewis acid metal with a bad solvent to a crosslinking reaction. This catalyst is useful as a catalyst in aldol reactions, cyanolation reactions, allylation reactions, Michael reactions, Mannich reactions, Diels Alder reactions and Friedel Crafts reactions.

摘要翻译： 目的是监测聚合物中的路易斯酸金属，并使该催化剂可恢复，同时保持其作为路易斯酸金属催化剂的功能。 本发明是一种聚合物 - 监控的路易斯酸金属催化剂，其中路易斯酸金属在交联聚合物中被监控，交联聚合物使用可交联聚合物中所含的交联基团进行交联。 聚合物监控的路易斯酸金属催化剂的特征在于含有至少一种含有疏水取代基的单体单元和含有交联基团的亲​​水取代基的交联聚合物，疏水性取代基含有芳族取代基。 该可交联聚合物优选包含至少一种含有疏水取代基的单体单元和含有交联基团的亲​​水取代基和含有疏水取代基的单体单元。 该催化剂可以通过将通过将含有可交联聚合物的有机溶液和路易斯酸金属得到的聚合物胶束监控的路易斯酸金属与不良溶剂进行交联反应来获得。 该催化剂可用作醛醇反应，硅烷醇化反应，烯丙基化反应，迈克尔反应，曼尼希反应，狄尔斯阿尔德反应和Friedel Crafts反应中的催化剂。

公开(公告)号：US07164043B2

公开(公告)日：2007-01-16

申请号：US10507027

申请日：2003-03-07

申请人： Shu Kobayashi ,  Masaharu Sugiura

发明人： Shu Kobayashi ,  Masaharu Sugiura

IPC分类号： C07C209/60

CPC分类号： C07C269/06 ,  B01J27/13 ,  B01J31/30 ,  C07C271/18 ,  C07C271/24

摘要： A conjugate addition reaction between an α,β-unsaturated ketone compound and a carbamate compound is carried out to synthesize a β-aminoketone, a salt or a hydrate salt of a transition metal of Groups 7 to 11 of the Periodic Table of Elements being present in the reaction system as the catalyst. The novel method and the catalyst are capable of synthesizing the β-aminoketone by the Aza-Michael reaction with high yield and efficiency.

摘要翻译： 进行α，β-不饱和酮化合物和氨基甲酸酯化合物之间的共轭加成反应，以合成出现的元素周期表第7〜11族的过渡金属的β-氨基酮，盐或水合物盐 在反应体系中作为催化剂。 新方法和催化剂能够以高产率和高效率通过Aza-Michael反应合成β-氨基酮。

公开(公告)号：US20040058806A1

公开(公告)日：2004-03-25

申请号：US10642160

申请日：2003-08-18

申请人： Wako Pure Chemical Industries, Ltd. ,  Shu Kobayashi

发明人： Kuniaki Okamoto ,  Mutsumi Sato ,  Atsunori Sano

IPC分类号： B01J031/00

CPC分类号： C08F8/42 ,  B01J23/466 ,  B01J31/06 ,  B01J31/1625 ,  C08K2201/013

摘要： The present invention relates to {circle over (1)} a metal oxide or metallic Lewis acid composition comprising the metal oxide or the metallic Lewis acid carried on a cross-linked polymer compound, {circle over (2)} a metal compound composition comprising the metal compound carried on a cross-linked product of a polymer compound containing a cross-linkable condensing functional group and/or a polymer containing a polymerizable double bond formed by a condensation reaction, {circle over (3)} a method for producing a metal compound composition comprising the metal compound carried on a cross-linked polymer compound, which comprises mixing a non-cross-linked polymer compound containing a cross-linkable condensing functional group and/or a polymer compound containing a polymerizable double bond formed by a condensation reaction with a metal compound, and then cross-linking the polymer compound, {circle over (4)} a carrier for carrying a metal compound comprising a 1st polymer compound containing a cross-linkable condensing functional group and/or a 2nd polymer compound containing a polymerizable double bond formed by a condensation reaction as a non-cross-linked polymer compound and {circle over (5)} a method for improving solvent resistance, heat resistance and durability of a metal compound comprising mixing a non-cross-linked polymer compound containing a cross-linkable condensing functional group and/or a polymer compound containing a polymerizable double bond formed by a condensation reaction with a metal compound, and then cross-linking said polymer compounds.

摘要翻译： 本发明涉及{圆周（1个金属氧化物或金属路易斯酸组合物，其包含金属氧化物或交联聚合物化合物上携带的金属路易斯酸），{圆周（2）包含载有金属化合物的金属化合物组合物 在含有可交联缩合官能团的高分子化合物和/或含有通过缩合反应形成的可聚合双键的聚合物的交联产物上{圆周（3）制备包含金属的金属化合物组合物的方法 在交联聚合物化合物上携带的化合物，其包括将含有可交联缩合官能团的非交联聚合物化合物和/或含有通过缩合反应形成的可聚合双键的高分子化合物与金属化合物混合， 然后交联高分子化合物{圆圈（4）用于承载含有含有1〜3个碳原子的第1高分子化合物的金属化合物的载体 可交联缩合官能团和/或含有通过缩合反应形成的可聚合双键的第二聚合物化合物作为非交联聚合物化合物和{循环（5）一种提高耐溶剂性，耐热性和耐久性的方法 金属化合物包括将含有可交联缩合官能团的非交联聚合物化合物和/或含有通过缩合反应形成的可聚合双键的高分子化合物与金属化合物混合，然后将所述聚合物化合物 。

公开(公告)号：US6107503A

公开(公告)日：2000-08-22

申请号：US38132

申请日：1998-03-11

申请人： Shu Kobayashi

发明人： Shu Kobayashi

IPC分类号： B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07C227/12 ,  C07C227/32 ,  C07C229/34 ,  C07C241/04 ,  C07C243/38 ,  C07C327/22 ,  C07D307/54 ,  C07D405/04 ,  C01G25/00 ,  C01G25/04

CPC分类号： B01J31/223 ,  C07C227/32 ,  C07C241/04 ,  C07D307/54 ,  C07D405/04 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/48

摘要： It is made possible to carry out asymmetric organic syntheses such as an asymmetric imono aldol reaction etc. catalytically with high reactivity and selectivity. An asymmetric zirconium catalyst having a structure that zirconium (IV) being an active central atom of the catalyst and being bonded via oxygen atoms to two molecules of optically active binaphthyl groups is proposed.

摘要翻译： 可以以高的反应性和选择性催化地进行不对称的有机合成，例如不对称的imono醛醇反应等。 提出了一种不对称锆催化剂，其具有锆（Ⅳ）是催化剂的活性中心原子并通过氧原子键合到两个光学活性联萘基的结构。

公开(公告)号：US08563765B2

公开(公告)日：2013-10-22

申请号：US12922008

申请日：2009-02-27

申请人： Shu Kobayashi ,  Yasuhiro Yamashita ,  Kazutaka Seki

发明人： Shu Kobayashi ,  Yasuhiro Yamashita ,  Kazutaka Seki

IPC分类号： C07C229/00

CPC分类号： C07F9/4056 ,  B01J31/0222 ,  B01J31/0237 ,  B01J31/0251 ,  B01J31/0271 ,  B01J31/1805 ,  B01J2231/346 ,  B01J2531/20 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C251/24 ,  C07C271/22 ,  C07C2601/14 ,  C07C2603/18 ,  C07D307/52 ,  C07F9/4006 ,  C07F9/65515 ,  C07F9/655345

摘要： Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.

公开(公告)号：US08318967B2

公开(公告)日：2012-11-27

申请号：US12224636

申请日：2007-02-27

申请人： Shu Kobayashi ,  Hidekazu Oyamada ,  Ryo Akiyama ,  Takeshi Naito

发明人： Shu Kobayashi ,  Hidekazu Oyamada ,  Ryo Akiyama ,  Takeshi Naito

IPC分类号： C07F7/08 ,  C07F7/02 ,  C07F7/00

CPC分类号： C07C67/303 ,  B01J23/40 ,  B01J23/70 ,  B01J31/124 ,  B01J31/127 ,  B01J31/165 ,  B01J31/26 ,  B01J31/28 ,  B01J35/006 ,  B01J37/0219 ,  B01J2231/4261 ,  B01J2231/641 ,  B01J2531/824 ,  B01J2531/828 ,  C07B2200/11 ,  C07C2/861 ,  C07C5/03 ,  C07C5/08 ,  C07C67/343 ,  C07C205/19 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/72 ,  C07F15/0066 ,  C07F15/0086 ,  C07F15/0093 ,  C07C15/54 ,  C07C15/18 ,  C07C69/612 ,  C07C69/618

摘要： The present invention provides a polysilane-supported transition metal catalysts or a polysilane/inorganic compound-supported transition metal catalysts, wherein various types of transition metals are supported by polysilane compounds, or combination of polysilanes and inorganic compounds. The catalysts of the present invention are hardly soluble in hydrocarbons and alcohols and are useful as catalysts in heterogeneous system for various organic synthetic reactions using the above solvents. Polysilanes supporting transition metals are easily crosslinkable by thermal treatment, microwave irradiation, UV irradiation or chemical methods such as hydrosilylation reaction and are changed to be insoluble in various solvents keeping high catalytic activity. Moreover, the stability and operability of polysilane-supported transition metal catalysts will be improved by the support thereof on inorganic compounds. These polysilane-supported transition metal catalysts show a high catalytic activity in hydrogenation reaction, hydrosilylation reaction, Heck reaction, Suzuki-Miyaura coupling reactions and the like. The catalyst is easily recoverable and reusable and the leakage of metals is extremely few.

摘要翻译： 本发明提供一种聚硅烷负载的过渡金属催化剂或聚硅烷/无机化合物负载的过渡金属催化剂，其中各种类型的过渡金属由聚硅烷化合物或聚硅烷和无机化合物的组合负载。 本发明的催化剂几乎不溶于烃和醇，并且可用作用于使用上述溶剂的各种有机合成反应的异相体系中的催化剂。 支撑过渡金属的聚硅烷通过热处理，微波照射，UV照射或氢化硅烷化反应等化学方法易于交联，并且改变为不溶于保持高催化活性的各种溶剂。 此外，通过其对无机化合物的支持，聚硅烷负载的过渡金属催化剂的稳定性和可操作性将得到改善。 这些聚硅烷负载的过渡金属催化剂在氢化反应，氢化硅烷化反应，Heck反应，Suzuki-Miyaura偶联反应等中显示出高的催化活性。 催化剂易于回收和再利用，金属的泄漏极少。

公开(公告)号：US20110054190A1

公开(公告)日：2011-03-03

申请号：US12865053

申请日：2009-01-28

申请人： Shu Kobayashi ,  Magno Agostinho ,  Uwe Schneider ,  Miyuki Yamaguchi

发明人： Shu Kobayashi ,  Magno Agostinho ,  Uwe Schneider ,  Miyuki Yamaguchi

IPC分类号： C07D207/02 ,  C07C67/00 ,  C07F3/00

CPC分类号： C07C311/16 ,  B01J31/0212 ,  B01J31/1805 ,  B01J2231/348 ,  B01J2531/21 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/24 ,  B01J2531/25 ,  C07B53/00 ,  C07B2200/07 ,  C07C67/347 ,  C07C201/12 ,  C07C2602/10 ,  C07D207/325 ,  C07D307/54 ,  C07D333/24 ,  C07C69/738 ,  C07C205/56

摘要： Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.]

摘要翻译： 公开了一种能够实现不需要大量丙二酸酯的有效的不对称迈克尔加成反应的技术，同时反应时间短。 具体公开的是由MX2（其中M为Be，Mg，Ca，Sr，Ba或Ra，X为任意基团）和通式[I]表示的化合物组成的催化剂。 [式中，R 7，R 8，R 9，R 10分别表示取代的环状基团或未取代的环状基团。

公开(公告)号：US07754898B2

公开(公告)日：2010-07-13

申请号：US10587075

申请日：2005-01-24

申请人： Shu Kobayashi

发明人： Shu Kobayashi

IPC分类号： C07D207/14 ,  C07C229/00 ,  C07C237/00

CPC分类号： C07B53/00 ,  B01J31/1805 ,  B01J2231/341 ,  B01J2531/16 ,  C07B2200/07 ,  C07C231/18 ,  C07D207/273

摘要： An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH═N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.

摘要翻译： 可用作药物，农药，香料，功能性聚合物等的原料或合成中间体的氨基酸化合物的不对称合成。提供了一种亚胺化合物的富含选择性亲核加成反应的方法， 伴随氨基形成的酰胺化合物与亚胺基的亚氨基（-CH = N-）的亲核加成反应，其特征在于反应在手性铜催化剂存在下进行。 此外，提供了一种合成上述应用的氨基酸化合物等的新方法。

公开(公告)号：US07659424B2

公开(公告)日：2010-02-09

申请号：US10591094

申请日：2005-02-24

申请人： Shu Kobayashi ,  Masaharu Sugiura

发明人： Shu Kobayashi ,  Masaharu Sugiura

IPC分类号： C07C241/02 ,  C07C227/04 ,  C07C229/08 ,  C07C243/38

CPC分类号： C07C241/02 ,  C07B53/00 ,  C07C2601/14 ,  C07C243/38

摘要： [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.

摘要翻译： [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。 用于解决问题的方法制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：[其中R 0是任选取代的烃基，任选取代的杂环基或-COOR 1（其中R 1是 烃基）; R2是酰基; R3和R4各自为氢，R3和R4中的一个为氢，另一个为烃基; R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R 0和R 2如上定义]与烯丙基化试剂如烯丙基三氯硅烷或基环丙基三氯硅烷反应 存在手性氧化膦。

公开(公告)号：US20080058200A1

公开(公告)日：2008-03-06

申请号：US10590206

申请日：2005-03-07

申请人： Shu Kobayashi ,  Kuniaki Okamoto ,  Ryo Akiyama ,  Keiji Ohno ,  Yoshio Inagaki

发明人： Shu Kobayashi ,  Kuniaki Okamoto ,  Ryo Akiyama ,  Keiji Ohno ,  Yoshio Inagaki

IPC分类号： B01J31/06

CPC分类号： C07C67/31 ,  B01J31/069 ,  B01J31/165 ,  B01J2231/4261 ,  B01J2231/643 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  C07C17/14 ,  C07C45/68 ,  C07C49/796 ,  C07C67/343 ,  C08F212/08 ,  C08F212/14 ,  C07C22/04 ,  C07C69/732 ,  C07C69/618

摘要： The objective is to present compositions obtained by supporting by polymers micro clusters of transition metals and the like that are useful as catalysts in various reactions and, once used, are readily recovered and reused.A polymer-supported metal cluster composition is obtained by supporting a transition metal by a cross-linked polymer, and the polymer-supported cluster composition is characterized by the cross-linked polymer obtained by cross-linking of a cross-linkable polymer containing a hydrophilic side chain and a hydrophobic side chain group having a cross-linkable functional group. This polymer-supported metal cluster composition is, for example, preferably formed by first forming a micelle composed of the metal clusters supported by the cross-linkable polymer in a suitable solution and subsequently subjecting the cross-linkable polymer to a cross-linking reaction. The composition is useful as a catalyst and the like in hydrogenation reactions, dehydrogenation reactions, allylic substitution reactions, oxidation reactions, coupling reactions and carbonylation reactions.

摘要翻译： 目的是提供通过聚合物支撑的组合物，所述过渡金属等的微簇等可用作各种反应中的催化剂，并且一旦使用，就容易回收和重复使用。 聚合物负载的金属簇组合物通过用交联聚合物负载过渡金属而获得，聚合物负载的簇组合物的特征在于通过交联含有亲水性的交联聚合物而获得的交联聚合物 侧链和具有可交联官能团的疏水侧链基团。 该聚合物负载的金属簇组合物例如优选通过首先在合适的溶液中形成由可交联聚合物负载的金属簇构成的胶束，然后使可交联聚合物进行交联反应而形成。 该组合物可用作氢化反应，脱氢反应，烯丙基取代反应，氧化反应，偶联反应和羰基化反应中的催化剂等。