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公开(公告)号：US12279630B2
公开(公告)日：2025-04-22
申请号：US16961942
申请日：2019-01-16
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)
Inventor： Mona Kidon , Ran Hovav
Abstract: A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.
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公开(公告)号：US20240041902A1
公开(公告)日：2024-02-08
申请号：US18266029
申请日：2021-12-08
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization , Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventor： Hinanit KOLTAI , Omer ANIS
IPC: A61K31/00 , A61K31/407 , A61P35/00
CPC classification number: A61K31/658 , A61K31/407 , A61P35/00
Abstract: Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.
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公开(公告)号：US11827687B2
公开(公告)日：2023-11-28
申请号：US17591620
申请日：2022-02-03
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady Kostenich , Mor Oron-Herman , Arie Orenstein , Talia Shekhter Zahavi , Ehud Gazit , Yoseph Salitra , Ludmilla Buzhansky
CPC classification number: C07K14/655 , A61K38/08 , A61K38/12 , A61K47/62 , A61K47/6923 , A61K47/6933 , A61K47/6937 , A61K49/0043 , A61K49/0056 , A61K49/0093
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20230310204A1
公开(公告)日：2023-10-05
申请号：US17927987
申请日：2021-05-27
Inventor： Shlomi COHEN , Tamir BEN DAVID , Tovy SIVAN
IPC: A61F6/22
CPC classification number: A61F6/225
Abstract: A contraceptive device is provided including an occluding component for deployment in a tubal lumen of a reproductive organ. The device includes an expandable frame reversibly expandable from a collapsed state to an expanded state and a barrier supported by the expandable frame. In the expanded state the barrier is disposed between the expandable frame and walls of the lumen to inhibit in-growth of cellular material into and onto the occluding component, and additionally the barrier is urged against walls of the tubal lumen to define at least two tube lumen sealing areas, disposed perpendicular to a longitudinal axis of the walls of the tube lumen such that (i) the expandable frame is disposed between the two tubal lumen sealing surface, and (ii) passage of reproductive cells through the expandable frame, and through the tube lumen is blocked, therefore, creating a the complete blockage for liquids from a first part of the tube to a second part of the tube, downstream the first part. Other applications are also described.
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公开(公告)号：US11712248B2
公开(公告)日：2023-08-01
申请号：US16706986
申请日：2019-12-09
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , The Trendlines Group Ltd.
Inventor： Abraham Tsur , Sharon Farber , Roy Mashiach , Yosef Hazan , David Shashar , Avshalom Shenhav
CPC classification number: A61B17/122 , A61B5/4356 , A61B5/6846 , A61B5/6847 , A61B5/6882 , A61B5/6885 , A61B17/1227 , A61B17/42 , A61F6/08 , A61M31/00 , A61B5/435 , A61B2017/00221 , A61B2017/00535 , A61B2017/00734 , A61B2017/00893 , A61B2017/4225 , A61B2090/065 , A61B2090/0811
Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.
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Patent Agency Ranking
公开(公告)号：US20230149214A1
公开(公告)日：2023-05-18
申请号：US18098291
申请日：2023-01-18
Inventor： Gilad Lavi , Yoseph Glovinsky , Vadim Shmukler , Nir Israeli
IPC: A61F9/007
CPC classification number: A61F9/00763
Abstract: Medical devices and methods for removing a predetermined portion of soft tissue from a target tissue layer, thereby creating a channel between two side walls of the target tissue layer, are described. The medical device is a cutting tool comprising: an elongated round body extending along a longitudinal axis and having a uniform outer cross-section at a proximal side thereof; a cutting portion at a distal side of the elongated body, comprising at a distal end thereof a cutting edge of a first cross-section being smaller than said outer cross-section, and a distally and continuously decreasing outer cross-section; and a chamber extending along the longitudinal axis inside the cutting tool from said cutting portion, the chamber having dimensions enabling storing of the removed soft tissue portion inside the chamber thereby providing a validation to the channel creation.
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公开(公告)号：US20230140799A1
公开(公告)日：2023-05-04
申请号：US17910293
申请日：2021-04-11
Inventor： Eitan GIAT , Yahel GIAT , Itamar GOLDSTEIN
IPC: A61K31/7105 , C12N15/86 , A61P31/14
Abstract: There is provided a decoy transcript derived from a ssRNA virus (WV), the transcript comprising at least one of a 5′UTR of the WV, a genomic packaging signal (GPS) of the WV, a 3′UTR of the WV, and an exogenous stop codon.
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公开(公告)号：US11564836B2
公开(公告)日：2023-01-31
申请号：US16420194
申请日：2019-05-23
Applicant: Ramot at Tel Aviv University Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Michael Belkin , Mordechai Goldenfeld
Abstract: An apparatus includes a laser source and a scanner. The laser source is configured to generate electromagnetic radiation. The scanner scans at least part of a limbal area of an eye with the electromagnetic radiation generated by the laser source, thereby directing the electromagnetic radiation through an entire thickness of the limbal area of the eye without any contact with the eye and irradiating one or more regions of a trabecular meshwork of the eye with the electromagnetic radiation.
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公开(公告)号：US20220135979A1
公开(公告)日：2022-05-05
申请号：US17430072
申请日：2020-02-27
Inventor： Ruty SHAI , Shany FREEDMAN PICCIOTTO , Amos TOREN
IPC: C12N15/113 , C12Q1/6806 , C12Q1/6851 , C12Q1/6886 , A61K31/713 , A61P35/00
Abstract: Methods for classifying, identifying and monitoring of a medulloblastoma tumor in a subject are provided, based on lincRNA expression in the tumor and/or in a biological sample of the subject. Compositions and methods for treating medulloblastoma using inhibitors of the specific lincRNAs disclosed herein. Additionally, novel inhibitory nucleic acids targeting the specific lincRNAs are provided.
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公开(公告)号：US20220080093A1
公开(公告)日：2022-03-17
申请号：US17416508
申请日：2019-12-26
Inventor： Alexander KOGAN
Abstract: A controller for controlling an apparatus comprising a blood pump, oxygenator, and blood filtering system connected together by blood flow tubing and to a patient to circulate blood from the patient through the apparatus and back to the patient, to oxygenate and filter the blood, the controller comprising at least one communication interface operable to receive signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus and configured to: determine values for the monitored parameters based on the monitoring signals; determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within a normative range for the parameter; and generate an alarm to alert an operator of the system if the value is not within the normative range.
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