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公开(公告)号：US11751779B2
公开(公告)日：2023-09-12
申请号：US18069551
申请日：2022-12-21
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Boris P. Kovatchev , Marc D. Breton , Stephen D. Patek
CPC classification number: A61B5/14532 , A61B5/0002 , A61B5/0004 , A61B5/4839 , A61B5/7275 , A61B5/746 , A61M5/1723 , G16H20/17 , G16H40/63 , G16H50/50 , G16H40/67
Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.
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42.发明授权公开(公告)号：US11743081B2
公开(公告)日：2023-08-29
申请号：US17249187
申请日：2021-02-23
Applicant: University of Virginia Patent Foundation
Inventor： Anjana Dissanayake
CPC classification number: H04L27/04 , H04B1/0096 , H04L27/0014
Abstract: Methods and apparatus are described in which IF content is generated at an RF receiver without off-chip MEMS, a local oscillator, or a phase-locked loop, and using a transmitter that transmits a single RF tone.
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43.发明公开公开(公告)号：US20230242989A1
公开(公告)日：2023-08-03
申请号：US17603150
申请日：2020-04-13
Applicant: University of Virginia Patent Foundation
Inventor： Anindya Dutta , Pankaj Kumar
IPC: C12Q1/6886 , C12N15/10
CPC classification number: C12Q1/6886 , C12N15/1065 , C12Q1/6806
Abstract: Provided are methods and kits for detecting an extrachromosomal circular DNA (eccDNA) in a biological sample. In some embodiments, the method comprises treating the biological sample to produce a tagged linearized fragment of genomic DNA; and determining whether the tagged linearized fragment is derived from an eccDNA to thereby detect the eccDNA. In some embodiments, the treating of the biological sample to produce a tagged linearized fragment of genomic DNA comprises treating the biological sample with an insertional enzyme complex to produce a tagged linearized fragment of genomic DNA.
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公开(公告)号：US20230210816A1
公开(公告)日：2023-07-06
申请号：US17998800
申请日：2021-05-24
Inventor： Stephen J. Polyak , Shawn Herring , Jessica Wagoner , Judith White
IPC: A61K31/4045 , A61K31/496 , A61K31/47 , A61K31/135 , A61K9/00 , A61P31/14
CPC classification number: A61K31/4045 , A61K31/496 , A61K31/47 , A61K31/135 , A61K9/0053 , A61P31/14
Abstract: Methods for inhibiting or treating viral infection in a subject infected with a vims of the arenaviridae family with a therapeutic agent combination: (a) arbidol and aripiprazole; (b) arbidol and amodiaquine; (c) arbidol and sertraline; (d) arbidol, iprazole, and amodiaquine; (e) arbidol, aripiprazole, and sertraline; or (f) aripiprazole and amodiaquine; or pharmaceutically acceptable salts thereof.
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公开(公告)号：US20230178350A1
公开(公告)日：2023-06-08
申请号：US18063975
申请日：2022-12-09
Inventor： Donald F. HUNT , Ann M. ENGLISH , Scott A. UGRIN , Dina L. BAI , Jeffrey SHABANOWITZ , John Edward Philip SYKA
CPC classification number: H01J49/0072 , G01N33/6848 , H01J49/0031 , H01J49/04 , H01J49/4295 , G01N2560/00
Abstract: The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.
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Patent Agency Ranking
公开(公告)号：US20230173476A1
公开(公告)日：2023-06-08
申请号：US18163647
申请日：2023-02-02
Applicant: The University of Virginia Patent Foundation
CPC classification number: B01J31/1815 , B01J31/189 , B01J31/2226 , B01J31/2291 , C07C2/66 , B01J31/00 , C07C5/03 , B01J2231/46 , B01J2531/0244 , B01J2531/822 , B01J2540/225 , B01J2540/22
Abstract: Embodiments of the present disclosure provide for Rh(I) catalysts, methods of making alkenyl substituted arenes (e.g., allyl arene, vinyl arene, and the like), methods of making alkyl substituted arenes, and the like.
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公开(公告)号：US20230172877A1
公开(公告)日：2023-06-08
申请号：US17910613
申请日：2021-03-11
Applicant: University of Virginia Patent Foundation
Inventor： Kodimangalam S. Ravichandran , Christopher B. Medina
IPC: A61K31/132 , A61K31/661 , A61P29/00
CPC classification number: A61K31/132 , A61K31/661 , A61P29/00
Abstract: Disclosed aspects include characterizing of the metabolite secretome of apoptotic cells, deciphering metabolite-based communication between dying cells and neighboring live cells, and harnessing components of the secretome for beneficial effects in vivo. In representative embodiments, a composition comprising, consisting essentially of, or consisting of an effective amount of a plurality of metabolite compounds derived from an apoptotic cell is disclosed, as are methods of treating an inflammatory condition in a subject and modulating gene expression in a subject using the composition.
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公开(公告)号：US11617901B2
公开(公告)日：2023-04-04
申请号：US16401944
申请日：2019-05-02
Applicant: University of Virginia Patent Foundation
Inventor： David R. Brenin , Timothy Norman Showalter , John A. Hossack
IPC: A61N5/10
Abstract: Apparatus or techniques can include an applicator that can include an expandable element and an ultrasonic transducer. The applicator can be inserted into a cavity of a tissue region of a patient and images of the cavity and the applicator can be generated based on signals obtained from the ultrasonic transducer. Dosing of radiation can be determined based on the images and a dose of radiation can be delivered to the tissue region by a radiation source located in the applicator.
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公开(公告)号：US20230067811A1
公开(公告)日：2023-03-02
申请号：US17794338
申请日：2021-01-25
Applicant: University of Virginia Patent Foundation
Inventor： Jonathan Kipnis , Antoine Louveau , Sandro Da Mesquita
IPC: A61K38/18 , C12Q1/6883 , A61P25/28
Abstract: In some embodiments herein, methods, compositions, and uses for modulating lymphatic vessels of the central nervous system are described. In some embodiments, methods, compositions, or uses for treating, preventing, or ameliorating symptoms of a neurological disease comprise increasing flow via meningeal lymphatic vessels are described.
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公开(公告)号：US11590501B2
公开(公告)日：2023-02-28
申请号：US17445972
申请日：2021-08-26
Applicant: University of Virginia Patent Foundation
Inventor： Nathan Swami , Walter Varhue , Linda W. Langman , Kenneth Brayman , Shayn Peirce-Cottler
Abstract: A microfluidic device can include an upstream passage, a sample passage, a bifurcating passage, and a combining passage. The upstream passage can be configured to provide a focusing stream. The sample passage can be configured to provide a sample stream. The bifurcating passage can include a specified bifurcating flow resistance. The combining passage can be configured to create a combined stream from the focusing stream and the sample stream, where the focusing stream can direct the sample stream away from the upstream passage and toward the bifurcating passage. A first portion of the combined stream can be discharged through the bifurcating passage. The main discharge can be configured to discharge a second portion of the combined stream. The main discharge can include a main discharge resistance that is selectable to vary the main discharge resistance relative to the bifurcating flow resistance.
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