公开(公告)号：US20170166519A1

公开(公告)日：2017-06-15

申请号：US15124748

申请日：2015-03-12

Applicant: UNIVERSITY OF WARWICK

Inventor： Andrew EASTON ,  Phillip GOULD ,  Andrew MARSH

IPC: C07C275/30 ,  C07C275/40 ,  C07C323/44 ,  G01N33/53 ,  C07C317/42 ,  C07D239/42 ,  C07D295/16 ,  G01N33/573 ,  C07C275/42 ,  C07D213/75

CPC classification number: C07C275/30 ,  A61K31/17 ,  A61K31/4402 ,  A61K31/505 ,  A61K31/5375 ,  C07C275/34 ,  C07C275/40 ,  C07C275/42 ,  C07C317/42 ,  C07C323/36 ,  C07C323/44 ,  C07C335/16 ,  C07C2601/14 ,  C07D213/72 ,  C07D213/75 ,  C07D239/42 ,  C07D295/16 ,  C12Q1/18 ,  C12Y306/04013 ,  G01N33/5308 ,  G01N33/56983 ,  G01N33/573 ,  G01N2333/135 ,  G01N2333/914 ,  G01N2500/02

Abstract: The invention relates to a DDX3X inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R1, X, L, Ra and Rb are as defined herein. The invention also relates to compounds of Formula (I).

公开(公告)号：US20160272663A1

公开(公告)日：2016-09-22

申请号：US15066830

申请日：2016-03-10

Applicant: University of Warwick

Inventor： Ying Fu ,  Peter John Sadler ,  Abraha Habtemariam

IPC: C07F15/00

CPC classification number: C07F15/002

Abstract: The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is also provided novel osmium containing complexes, as well as pharmaceutical formulations comprising such complexes.

公开(公告)号：US20160195570A1

公开(公告)日：2016-07-07

申请号：US15069815

申请日：2016-03-14

Applicant: University of Warwick

Inventor： Patrick Unwin ,  Kim Martin McKelvey

IPC: G01Q60/60

CPC classification number: G01Q60/60 ,  B22D19/14 ,  C23C26/02 ,  E21C35/183 ,  E21C2035/1806 ,  E21C2035/1809 ,  E21C2035/1813 ,  Y10T428/12937 ,  Y10T428/12965

Abstract: A new scanning electrochemical microscopy tip positioning method that allows topography and surface activity to be resolved independently is presented. A SECM tip is oscillated relative to the surface of interest. Changes in the oscillation amplitude, caused by the intermittent contact of the SECM tip with the surface of interest, are used to detect the surface of interest, and as a feedback signal for various types of imaging.

公开(公告)号：US20150129436A1

公开(公告)日：2015-05-14

申请号：US14398707

申请日：2013-05-01

Applicant: The University of Warwick

Inventor： Patrick Robert Unwin ,  Kim Martin McKelvey

IPC: G01Q60/60

CPC classification number: G01Q60/60 ,  B82Y35/00

Abstract: A method of controlling a scanning electrochemical microscopy probe tip comprising the following steps: oscillating the scanning electrochemical microscopy probe tip relative to the surface of interest; moving the oscillating scanning electrochemical microscopy probe tip towards the surface of interest; detecting damping of an amplitude of the oscillation of the scanning electrochemical microscopy probe tip resulting from the scanning electrochemical microscopy probe tip coming into contact with the surface of interest at the first location; using the detected damping to detect the surface of interest; retracting the scanning electrochemical microscopy probe tip away from the surface of interest without first translating the scanning electrochemical microscopy probe tip along the surface of interest whilst the scanning electrochemical microscopy probe tip is in intermittent contact with the surface of interest. The method further comprises measuring electrochemical signals produced at the oscillating scanning electrochemical microscopy probe tip whilst moving the oscillating scanning electrochemical microscopy probe tip towards and/or away from the surface of interest.

Abstract translation: 一种控制扫描电化学显微镜探针尖端的方法，包括以下步骤：相对于感兴趣的表面振荡扫描电化学显微镜探针尖端; 将振荡扫描电化学显微镜探针尖端移向感兴趣的表面; 检测扫描电化学显微镜探针尖端的振荡幅度的阻尼，其由扫描电化学显微镜探针尖端在第一位置处与感兴趣的表面接触; 使用检测到的阻尼来检测感兴趣的表面; 在扫描电化学显微镜探针尖端与感兴趣的表面间歇接触时，将扫描电化学显微镜探针尖端远离目标表面缩回，而不首先沿着感兴趣的表面平移扫描电化学显微镜探针尖端。 该方法还包括测量在振荡扫描电化学显微镜探针尖端处产生的电化学信号，同时将振荡扫描电化学显微镜探针尖端朝向和/或远离感兴趣的表面移动。

公开(公告)号：US20150037842A1

公开(公告)日：2015-02-05

申请号：US14382084

申请日：2013-02-22

Applicant: The University of Warwick

Inventor： Colin Robinson

IPC: C12N15/70 ,  C12P21/00

CPC classification number: C12N15/70 ,  C12N9/52 ,  C12P21/00 ,  C12P21/02

Abstract: The disclosure relates to a Gram negative bacterial cell that is transformed with a nucleic acid molecule that encodes a Gram positive twin-arginine translocase and including methods for the production of polypeptides.

Abstract translation: 本公开涉及用编码革兰氏阳性双精氨酸转位酶的核酸分子转化的革兰氏阴性细菌细胞，并且包括用于产生多肽的方法。

公开(公告)号：US12297557B2

公开(公告)日：2025-05-13

申请号：US17759173

申请日：2021-03-04

Applicant: Element Six Technologies Limited ,  University of Warwick

Inventor： Joshua James Tully ,  Samuel James Cobb ,  Julie Victoria MacPherson ,  Mark Edward Newton ,  Matthew Lee Markham

IPC: C25F3/12 ,  C01B32/25 ,  C01B32/28 ,  C23C14/06 ,  C23C14/48 ,  C25F3/14 ,  C30B29/04 ,  C30B33/10

Abstract: A method for forming a diamond product. Diamond material is provided and a damage layer comprising sp2 bonded carbon is formed in the material. The presence of the damage layer defines a first diamond layer above and in contact with the damage layer and a second diamond layer below and in contact with the damage layer. The damage layer is electrochemically etched to separate it from the first layer, wherein the electrochemical etching is performed in a solution containing ions, the solution having an electrical conductivity of at least 500 μS cm−1, and wherein the ions are capable of forming radicals during electrolysis. The diamond product is also described.

公开(公告)号：US12188897B2

公开(公告)日：2025-01-07

申请号：US18319263

申请日：2023-05-17

Applicant: Hach Lange GmbH ,  University of Warwick

Inventor： Zoë Duncan ,  Joshua James Tully

IPC: G01N27/30 ,  C01B32/28 ,  C25B11/043 ,  G01N27/416 ,  G01N33/18

Abstract: An embodiment provides a method for modifying a carbon region on a boron-doped diamond electrode surface, comprising: placing a boron-doped diamond electrode surface in an aqueous solution, wherein the aqueous solution comprises an ionic treatment solution; applying a voltage difference across the boron-doped diamond electrode surface; and modifying a carbon region on an area of the boron-doped diamond electrode surface, wherein the modifying is responsive to application of the voltage while the boron-doped diamond electrode surface is in the aqueous solution, wherein the modification continues until a desired signal of the carbon region is reached. Other aspects are described and claimed.

公开(公告)号：US20240175819A1

公开(公告)日：2024-05-30

申请号：US18072219

申请日：2022-11-30

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Andrea DSOUZA ,  Jérôme CHARMET ,  Chrystala CONSTANTINIDOU ,  Rachel Alice HAND

IPC: G01N21/78 ,  C12Q1/04 ,  G01N21/64

CPC classification number: G01N21/78 ,  C12Q1/04 ,  G01N21/6408

Abstract: A biosensor detects bacteria in a sample and/or carries out antimicrobial susceptibility testing of the bacteria to an antibiotic. The biosensor includes a crosslinked hydrogel. The crosslinked hydrogel contains a composition suspended therein, including (i) a bacterial nutrient media; (ii) optionally, an antibiotic; and (iii) an indicator for determining bacterial growth.

公开(公告)号：US20230375510A1

公开(公告)日：2023-11-23

申请号：US18246409

申请日：2021-09-23

Applicant: The University of Warwick

Inventor： Jan Specht ,  Marina Cole ,  Siavash Esfahani ,  Julian Gardner

IPC: G01N29/44 ,  G01N29/22 ,  G01N15/06 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/48

CPC classification number: G01N29/4436 ,  G01N29/221 ,  G01N15/0656 ,  G01N29/2431 ,  G01N29/343 ,  G01N29/42 ,  G01N29/4463 ,  G01N29/348 ,  G01N29/48

Abstract: A device for particle sensing is disclosed. The device includes a sensor including a bulk acoustic wave resonator having a resonant frequency, an acoustic mirror arranged to support the resonator, and a heater in thermal communication with the resonator such that a resonator temperature is based on a heater temperature. The device also includes circuitry connected to the sensor. The circuitry comprises a driver configured to drive the heater with a driver signal having a constant periodic cycle, and an oscillator configured to generate an output signal indicative of the resonant frequency. The resonant frequency is modulated by the resonator temperature.

公开(公告)号：US20230183595A1

公开(公告)日：2023-06-15

申请号：US17924247

申请日：2021-05-07

Applicant: The Lubrizol Corporation ,  University of Warwick

Inventor： Paul O'Hora ,  Dixit Parmar ,  Timothy R. Smith ,  David M. Haddleton ,  Georgios Patias

IPC: C10M149/00 ,  C08F8/32

CPC classification number: C10M149/00 ,  C08F8/32 ,  C10N2020/04

Abstract: The present invention provides, among other things, a process to produce a low molecular weight dispersant polymethacrylate polymer (“LMWDPMA”), and the LMWDPMA itself, along with the use of the LMWDPMA in a lubricating composition, as well as a method for lubricating an internal combustion engine as disclosed herein.