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公开(公告)号：US09556206B2
公开(公告)日：2017-01-31
申请号：US14841964
申请日：2015-09-01
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Anton Toutov , Kerry Betz , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
CPC classification number: C07F7/0827 , C07F17/02 , C07J1/0096 , C07J7/0005 , C07J51/00 , C07J75/00
Abstract: The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.
Abstract translation: 本发明涉及温和，有效和通用的直接C（sp）-H键甲硅烷基化。 各种实施方案包括方法，每种方法包括或基本上包括使至少一种包含末端炔基C-H键的有机底物与至少一种有机硅烷和碱金属氢氧化物的混合物在足以形成甲硅烷基化的末端炔基的条件下 部分。 所述方法在基本上不存在过渡金属化合物的情况下是可操作的。 还公开了与这些方法相关联的系统。
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公开(公告)号：US20160367669A1
公开(公告)日：2016-12-22
申请号：US15199710
申请日：2016-06-30
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Marshall L. Stoller , Hoyong Chung , Alissa M. Fitzgerald , Thomas W. Kenny , Renee M. Thomas
CPC classification number: A61K41/0028 , A61B17/22004 , A61B17/2202 , A61B17/22022 , A61B2017/22007 , A61B2017/22008 , A61K9/0009 , A61K9/0019 , A61K9/1075 , A61K31/663 , A61K41/0033 , A61K47/24 , A61K47/6911 , A61N7/00 , A61N2007/0039
Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US09403854B2
公开(公告)日：2016-08-02
申请号：US14055442
申请日：2013-10-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Arnab K. Chatterjee , Tae-Lim Choi , Steven D. Goldberg , Jennifer A. Love , John P. Morgan , Daniel P. Sanders , Matthias Scholl , F. Dean Toste , Tina M. Trnka
IPC: C07D233/02 , C07D233/12 , C07F9/40 , C07C6/04 , C07C17/275 , C07C29/40 , C07C45/69 , C07C67/293 , C07C67/343 , C07C67/475 , C07C319/20 , C07D263/14 , C07D317/12 , C07D317/20 , C07D317/24 , C07F7/18 , C07F15/00 , C07C201/12 , C07C29/46 , C07C41/14 , C07C67/297
CPC classification number: C07F9/40 , C07C6/04 , C07C17/275 , C07C29/40 , C07C29/46 , C07C41/14 , C07C45/69 , C07C67/293 , C07C67/297 , C07C67/343 , C07C67/475 , C07C201/12 , C07C319/20 , C07C2531/22 , C07C2601/14 , C07C2601/16 , C07C2603/74 , C07D263/14 , C07D317/12 , C07D317/20 , C07D317/24 , C07F7/1892 , C07F9/4015 , C07F15/0046 , C07C25/13 , C07C47/21 , C07C69/007 , C07C69/78 , C07C69/732 , C07C69/56 , C07C321/14 , C07C69/16 , C07C69/533 , C07C69/145 , C07C69/157 , C07C69/18 , C07C205/06 , C07C33/483
Abstract: The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.
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公开(公告)号：US09309269B2
公开(公告)日：2016-04-12
申请号：US14628641
申请日：2015-02-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Alexey Fedorov , Anton Toutov , Kerry Betz
IPC: C07F7/08
CPC classification number: C07F7/0829 , C07F7/081 , C07F7/0812 , C07F7/0814 , C07F7/0816 , C07F7/0896
Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.
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公开(公告)号：US09207532B2
公开(公告)日：2015-12-08
申请号：US14044974
申请日：2013-10-03
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Raymond Weitekamp , Robert H. Grubbs
CPC classification number: G03F7/0042 , G03F7/029 , G03F7/20
Abstract: The present invention provides photosensitive compositions and methods of patterning a polymeric image on a substrate, said methods comprising; (a) depositing a layer of photosensitive composition of any one of claims 15 to 22 on the substrate; and (b) irradiating a portion of the layer of photosensitive composition with a light comprising a wavelength in a range of from about 220 to about 440 nm. The invention also relates to methods of metathesizing an unsaturated organic precursor comprising irradiating Fischer-type carbene ruthenium catalysts with at least one wavelength of light in the presence of at least one unsaturated organic precursor so as to metathesize at least one alkene or one alkyne bond.
Abstract translation: 本发明提供光敏组合物和在基底上图案化聚合物图像的方法，所述方法包括： （a）在所述基底上沉积权利要求15至22中任一项所述的光敏组合物层; 和（b）用包含波长在约220至约440nm范围内的光照射光敏组合物层的一部分。 本发明还涉及使不饱和有机前体复元的方法，其包括在存在至少一种不饱和有机前体的情况下用至少一种波长的光照射费歇尔型卡宾钌催化剂，以便使至少一种烯烃或一个炔烃折析。
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Patent Agency Ranking
公开(公告)号：US09147844B2
公开(公告)日：2015-09-29
申请号：US13955251
申请日：2013-07-31
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Raymond Weitekamp
IPC: C08F2/34 , H01L51/00 , C08F38/02 , C08F4/26 , C08F4/80 , H01L51/05 , C09D5/16 , C08G61/04 , C08G61/08 , C08L65/00 , C09D5/00
CPC classification number: H01L51/0041 , C08F2/34 , C08F4/26 , C08F4/80 , C08F38/02 , C08G61/04 , C08G61/08 , C08G2261/418 , C08G2261/55 , C08G2261/90 , C08G2261/91 , C08G2261/92 , C08G2261/94 , C08G2261/95 , C08L65/00 , C09D5/006 , C09D5/16 , H01L51/0579 , Y02E10/549
Abstract: The disclosure describes methods of metathesizing unsaturated organic compounds, each method comprising contacting at least one feedstock comprising at least one olefinic or acetylenic precursor with a solid transition metal-based metathesis catalyst in the absence of a liquid solvent or precursor to form a polymer product.
Abstract translation: 本公开内容描述了使不饱和有机化合物复分解的方法，每种方法包括在不存在液体溶剂或前体的情况下，使包含至少一种烯属或炔属前体的至少一种原料与固体过渡金属基复分解催化剂接触以形成聚合物产物。
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公开(公告)号：US20150141640A1
公开(公告)日：2015-05-21
申请号：US14604917
申请日：2015-01-26
Inventor： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC: C07F7/28
CPC classification number: C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：
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公开(公告)号：US09000167B2
公开(公告)日：2015-04-07
申请号：US14043929
申请日：2013-10-02
Applicant: California Institute of Technology
Inventor： Robert H. Grubbs , Alexey Fedorov , Anton Toutov , Kerry Betz
IPC: C07F7/08
CPC classification number: C07F7/0829 , C07F7/081 , C07F7/0812 , C07F7/0814 , C07F7/0816 , C07F7/0896
Abstract: The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate; wherein said system is substantially free of a transition-metal compound.
Abstract translation: 本发明描述了用于甲硅烷基化芳族有机基质的化学体系和方法，所述体系包含（a）至少一种有机硅烷和（b）至少一种强碱的混合物，所述体系基本上不含过渡金属化合物， 所述方法包括在足以使芳族底物甲硅烷基化的条件下使一定量的有机底物与（a）至少一种有机硅烷和（b）至少一种强碱的混合物接触; 其中所述体系基本上不含过渡金属化合物。
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公开(公告)号：US11753421B2
公开(公告)日：2023-09-12
申请号：US17688122
申请日：2022-03-07
Applicant: California Institute of Technology
Inventor： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC: C07F7/08 , C07D209/12
CPC classification number: C07F7/0801 , C07D209/12 , C07F7/0827 , C07F7/0832
Abstract: The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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公开(公告)号：US20220162236A1
公开(公告)日：2022-05-26
申请号：US17557313
申请日：2021-12-21
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Robert H. Grubbs , Alexey Fedorov , Anton Toutov , Kerry N. Betz
IPC: C07F7/08 , C07C1/22 , C07C37/055 , C07C37/50 , C07C209/28 , C07C209/62 , C07C319/06
Abstract: The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
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