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403 条记录 (耗时 0.168 秒)

    Antibodies to HDPPA04 polypeptide
    42.
    发明授权
    Antibodies to HDPPA04 polypeptide 失效
    HDPPA04多肽的抗体

    公开(公告)号：US07411051B2

    公开(公告)日：2008-08-12

    申请号：US11001793

    申请日：2004-12-02

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/00

    CPC分类号： C07K14/47

    摘要： The present invention relates to antibodies that specifically bind HDPPA04 polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said HDPPA04. Also encompassed by the invention are host cells and hybridomas for producing said antibodies. The invention further encompasses methods for detecting said HDPPA04 polypeptides using said antibodies.

    摘要翻译： 本发明涉及特异性结合HDPPA04多肽的抗体，其可用于诊断和治疗与所述HDPPA04有关的疾病，病症和/或病症。 本发明还包括用于产生所述抗体的宿主细胞和杂交瘤。 本发明还包括使用所述抗体检测所述HDPPA04多肽的方法。

    Human G-protein chemokine receptor (CCR5) HDGNR10
    44.
    发明授权
    Human G-protein chemokine receptor (CCR5) HDGNR10 有权
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US07393934B2

    公开(公告)日：2008-07-01

    申请号：US10994679

    申请日：2004-11-23

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/28 ,  C12N15/13

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    Human secreted proteins
    45.
    发明授权
    Human secreted proteins 失效
    人体分泌的蛋白质

    公开(公告)号：US07368531B2

    公开(公告)日：2008-05-06

    申请号：US10100683

    申请日：2002-03-19

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K1/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/5058 ,  G01N33/5064 ,  G01N33/5088 ,  G01N33/68

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding the polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to the human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing the polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌的多肽和编码该多肽的分离的核酸分子，其可用于诊断和治疗与人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

    Albumin fusion proteins
    46.
    发明授权
    Albumin fusion proteins 有权
    白蛋白融合蛋白

    公开(公告)号：US07238660B2

    公开(公告)日：2007-07-03

    申请号：US11393893

    申请日：2006-03-31

    申请人： Craig A. Rosen ,  William A. Haseltine

    发明人： Craig A. Rosen ,  William A. Haseltine

    IPC分类号： C07K14/00

    CPC分类号： C07K14/76 ,  C07K14/4713 ,  C07K14/765 ,  C07K2319/00 ,  C12N15/62

    摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating or preventing diseases, disorders or conditions related to diabetes mellitus using albumin fusion proteins of the invention.

    摘要翻译： 本发明涵盖白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括使用本发明的白蛋白融合蛋白的包含白蛋白融合蛋白的药物组合物和治疗或预防与糖尿病有关的疾病，病症或病症的方法。

    Vascular endothelial growth factor 2
    47.
    发明授权
    Vascular endothelial growth factor 2 失效
    血管内皮生长因子2

    公开(公告)号：US07227005B1

    公开(公告)日：2007-06-05

    申请号：US09257272

    申请日：1999-02-25

    申请人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

    发明人： Jing-Shan Hu ,  Craig A. Rosen ,  Liang Cao

    IPC分类号： A61K38/24 ,  A61K37/27 ,  A61K38/00 ,  C07K1/00 ,  A01N37/18

    CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeutically useful fragments, analogs, or derivatives thereof, and DNA(RNA) encoding such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.

    摘要翻译： 公开了人VEGF2多肽，生物活性，诊断学或治疗上有用的片段，类似物或衍生物，以及编码这种VEGF2多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生，从而抑制肿瘤生长，炎症，糖尿病性视网膜病，类风湿性关节炎和牛皮癣的方法。

    Methods and compositions for treating metabolic bone diseases relating to human endokine alpha
    50.
    发明授权
    Methods and compositions for treating metabolic bone diseases relating to human endokine alpha 失效

    公开(公告)号：US07087225B2

    公开(公告)日：2006-08-08

    申请号：US10218547

    申请日：2002-08-15

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Bernadetta Nardelli

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Bernadetta Nardelli

    IPC分类号： A61K45/00 ,  A61K38/19 ,  C07K14/715

    CPC分类号： C07K14/5255 ,  A61K38/00

    摘要： The present invention concerns methods for diagnosis and treatment of metabolic bone diseases and disorders using a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular the invention provides methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders. Also provided by the invention are methods of using the Endokine alpha protein and/or homomultimeric and/or heteromultimeric polypeptide complexes containing Endokine alpha, in the diagnosis, prognosis and treatment of diseases and/or disorders associated with aberrant osteoclast development and/or activity. The present invention also provides isolated polynucleotides encoding polypeptides of the invention, antibodies thereto, and agonists and antagonists thereof, for use in the diagnosis, prognosis and treatment of metabolic bone diseases and disorders.