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    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS
    44.
    发明申请
    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
    电化学传感器电极系统

    公开(公告)号：US20120228134A1

    公开(公告)日：2012-09-13

    申请号：US13475770

    申请日：2012-05-18

    申请人： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    发明人： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3274 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/001

    摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.

    摘要翻译： 本发明一般涉及用于改进分析物的电化学测量的系统和方法。 优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。 通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。 通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

    Electrode systems for electrochemical sensors
    45.
    再颁专利
    Electrode systems for electrochemical sensors 有权
    电化学传感器用电极系统

    公开(公告)号：USRE43399E1

    公开(公告)日：2012-05-22

    申请号：US12139305

    申请日：2008-06-13

    申请人： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    发明人： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    IPC分类号： G01N27/327 ,  A61B5/05

    CPC分类号： G01N27/3274 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/001

    摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.

    摘要翻译： 本发明一般涉及用于改进分析物的电化学测量的系统和方法。 优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。 通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。 通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

    CALIBRANT INFUSION FLUID SOURCE PREPARATION
    48.
    发明申请
    CALIBRANT INFUSION FLUID SOURCE PREPARATION 有权
    CALIBRANT INFUSION流体源准备

    公开(公告)号：US20110154880A1

    公开(公告)日：2011-06-30

    申请号：US12827802

    申请日：2010-06-30

    申请人： James R. Petisce ,  Michael J. Higgins ,  Kristie Trinh ,  Todd Abraham

    发明人： James R. Petisce ,  Michael J. Higgins ,  Kristie Trinh ,  Todd Abraham

    IPC分类号： G01N33/48 ,  G01N33/00

    CPC分类号： G01N33/96 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61M2207/00 ,  A61M2230/201 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/104998 ,  Y10T436/108331

    摘要： Methods and systems for preparation of calibrant infusion fluid sources are disclosed. In one embodiment, a precise volume of glucose is injected into a saline-solution filled calibrant infusion fluid source proximate in time to conducting a calibration procedure. The glucose concentration in the calibrant infusion fluid source is subsequently calculated based on the measured weight of the saline-solution, as determined prior to glucose injection, and the volume of glucose injected. This method provides a highly accurate and convenient manner for use in a hospital environment, for example, with an intravenous blood glucose sensor system. In another embodiment, a premixed calibrant infusion fluid source is provided that includes saline solution and a predetermined concentration of glucose. In such embodiments, shelf life problems related to water evaporation are mitigated by hermetically covering or otherwise hermetically containing the calibrant infusion fluid source up until the point of use.

    摘要翻译： 公开了用于制备校准液输注液源的方法和系统。 在一个实施方案中，在时间上将精确体积的葡萄糖注入盐水溶液填充的校准液输注液源中以进行校准程序。 随后根据在注射葡萄糖之前测定的盐水溶液的测量重量和注入的葡萄糖体积来计算校准液输注液源中的葡萄糖浓度。 该方法提供了在医院环境中使用的高度准确和方便的方式，例如使用静脉内血糖传感器系统。 在另一个实施方案中，提供了预混合的校准液输注液源，其包括盐溶液和预定浓度的葡萄糖。 在这样的实施方案中，通过气密地覆盖或以其他方式密封含有校准液输注流体源直到使用点来减轻与水蒸发相关的保质期问题。