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178 条记录 (耗时 0.034 秒)

    Inhibitors of HSP90
    44.
    发明申请
    Inhibitors of HSP90 审中-公开
    HSP90抑制剂

    公开(公告)号：US20090039811A1

    公开(公告)日：2009-02-12

    申请号：US11658234

    申请日：2005-07-26

    申请人： Patrick Chene ,  Andreas Floersheimer ,  Pascal Furet ,  Joseph Schoepfer

    发明人： Patrick Chene ,  Andreas Floersheimer ,  Pascal Furet ,  Joseph Schoepfer

    IPC分类号： H02P7/29 ,  H02K7/14

    CPC分类号： A61K31/416 ,  C07D231/56

    摘要： The invention relates to the use of 1H-indazol-6-ol compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 1H-indazol-6-ol compounds, novel 1H-indazol-6-ol compounds, and a process for the preparation of the novel 1H-indazol-6-ol compounds.

    摘要翻译： 本发明涉及1H-吲唑-6-醇化合物及其盐在治疗增殖性疾病和制备用于治疗所述疾病的药物制剂中的用途，包括1H-吲唑-6-醇化合物的药物制剂， 新的1H-吲唑-6-醇化合物，以及制备新的1H-吲唑-6-醇化合物的方法。

    Methods of screening for compounds which inhibit the activity of Cdc34 in a zinc-mediated manner and compounds obtained by this method
    45.
    发明申请
    Methods of screening for compounds which inhibit the activity of Cdc34 in a zinc-mediated manner and compounds obtained by this method 审中-公开
    以锌介导方式筛选抑制Cdc34活性的化合物的方法和通过该方法获得的化合物的方法

    公开(公告)号：US20060211747A1

    公开(公告)日：2006-09-21

    申请号：US11226786

    申请日：2005-09-14

    申请人： Pascal Furet ,  Francesco Hofmann ,  Edgar Jacoby ,  Joseph Schoepfer

    发明人： Pascal Furet ,  Francesco Hofmann ,  Edgar Jacoby ,  Joseph Schoepfer

    IPC分类号： A61K31/43

    CPC分类号： A61K31/43

    摘要： The present invention relates to methods of searching/screening for compounds which inhibit the activity of the ubiquitin conjugating enzyme Cdc34 in a zinc-mediated manner, to compounds obtainable by such a method, to a method of treating mammalian subjects with such compounds, to pharmaceutical compositions containing such compounds, to the use of such compounds for the treatment of diseases which respond to an inhibition of the activity of Cdc34 such as proliferative diseases, especially tumor diseases, and to the use of such compounds for the preparation of such pharmaceutical compositions for the treatment of such diseases.

    摘要翻译： 本发明涉及以锌介导的方式检测/筛选抑制泛素缀合酶Cdc34的活性的化合物，通过这种方法可获得的化合物，将这些化合物治疗哺乳动物受试者的方法用于药物 含有这些化合物的组合物，用于这些化合物用于治疗对抑制Cdc34的活性（例如增殖性疾病，特别是肿瘤疾病）起反应的疾病，以及使用这些化合物制备这种药物组合物 治疗这种疾病。

    3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
    46.
    发明授权
    3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives 有权
    3-杂芳基甲基 - 咪唑并[1,2-b]哒嗪-6-基衍生物

    公开(公告)号：US08389526B2

    公开(公告)日：2013-03-05

    申请号：US12849642

    申请日：2010-08-03

    申请人： Pascal Furet ,  Clive McCarthy ,  Joseph Schoepfer ,  Stefan Stutz

    发明人： Pascal Furet ,  Clive McCarthy ,  Joseph Schoepfer ,  Stefan Stutz

    IPC分类号： A01N43/58 ,  A61K31/50 ,  C07D487/00

    CPC分类号： C07D487/04

    摘要： The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).

    摘要翻译： 本发明涉及式（I）化合物及其盐，其中取代基如本说明书中所定义，式（I）化合物在治疗人或动物体的方法中的应用，特别是关于 对C-Met酪氨酸激酶介导的疾病; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物的药物组合物，任选地在组合配偶体存在下; 制备式（I）化合物的方法。