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111 条记录 (耗时 0.031 秒)

    Thermally-activated microchip chemical delivery devices
    41.
    发明授权
    Thermally-activated microchip chemical delivery devices 有权
    热敏微芯片化学输送装置

    公开(公告)号：US06527762B1

    公开(公告)日：2003-03-04

    申请号：US09638109

    申请日：2000-08-11

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    IPC分类号： A61K911

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress. In another preferred embodiment, application of an electric current to a resistor located on or near the reservoir cap causes the cap to expand, contract, or undergo a phase change that results in the rupture of the reservoir cap. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

    摘要翻译： 提供Microchip输送装置，其控制释放分子的速率和时间，其中所述装置包括底物，所述基质中含有所述分子的至少一个储存器和位于所述分子上的所述储存器上的储存器盖，其中所述分子 在加热或冷却装置或其一部分足以破坏储存器盖时从储存器释放。 在优选实施例中，该装置包括集成在储存器中或安装在储存器附近的电阻器，当施加电流通过电阻器时，储存器的至少一个内容物热膨胀，蒸发，相变， 或经历热驱动反应，使得储存器盖由于机械应力而破裂。 在另一个优选实施例中，将电流施加到位于储存器盖上或附近的电阻器使得盖膨胀，收缩或经历相变，导致储存器盖的破裂。 储层可以含有多种药物或其他可变剂量的分子。 单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

    Preparation of highly textured oxide superconducting films from MOD precursor solutions
    44.
    发明授权
    Preparation of highly textured oxide superconducting films from MOD precursor solutions 失效
    从MOD前置解决方案制备高纹理氧化物超导膜

    公开(公告)号：US5231074A

    公开(公告)日：1993-07-27

    申请号：US510115

    申请日：1990-04-17

    申请人： Michael J. Cima ,  Paul McIntyre

    发明人： Michael J. Cima ,  Paul McIntyre

    IPC分类号： H01L39/24

    CPC分类号： H01L39/2451 ,  Y10S505/734

    摘要： Highly-textured superconductor oxide thin films are prepared on substrates, including lattice matched, non-lattice matThe Government has rights in this invention pursuant to contract Number MDA972-88-K0006 awarded by the U.S. Defense Advance Research Project Agency.

    摘要翻译： 通过金属有机沉积（MOD）在衬底上制备高纹理超导体氧化物薄膜，包括晶格匹配的，非晶格匹配的惰性和非惰性材料。 选择前体溶液组成以及加工温度和气氛以控制瞬态液相的存在。 以高度纹理化的形态和完全致密均匀的微观结构为特征的超导体氧化物膜在77°K时能够保持超过104A / cm 2的临界电流密度，当在非晶格匹配衬底上制备时，其临界电流密度超过106A / cm2，当在晶格匹配的基底上制备时。

    Device and Method for Sampling Bodily Fluid for Medical Analytes in Ultra Low Concentrations
    45.
    发明申请
    Device and Method for Sampling Bodily Fluid for Medical Analytes in Ultra Low Concentrations 有权
    用于超低浓度医用分析物体液取样的装置和方法

    公开(公告)号：US20140004503A1

    公开(公告)日：2014-01-02

    申请号：US13977108

    申请日：2011-12-30

    申请人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

    发明人： Michael J. Cima ,  Gregory J. Ekchian ,  Christophoros C. Vassiliou ,  Vincent H. Liu ,  Christoph Wald ,  Sebastian Flacke ,  Fredric D. Gordon

    IPC分类号： G01N1/34

    CPC分类号： G01N1/34 ,  A61F2/01 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/54313 ,  G01N33/56983

    摘要： Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.

    摘要翻译： 提供捕获装置和方法用于捕获血液或其它生物流体中的医学分析物。 该装置可以包括结构底物和粘附到结构底物上的结合剂，例如抗体，其中结合剂能够与医学分析物例如病毒颗粒结合或附着，并且该装置被配置用于 放置在患者体内的生物腔或血管（含有生物流体）中。 可以处于扭曲线圈形状的捕获装置构造成捕获存在于生物流体中的至少一些医学分析物（例如病毒颗粒）。 该方法可以包括将捕获装置部署到患者的血管中; 在部署之后一段时间后，将捕获装置从生物腔或血管中取出; 然后分析捕获装置以获得医用分析物的存在。

    Electrochemical actuator
    46.
    发明授权
    Electrochemical actuator 有权
    电化学执行器

    公开(公告)号：US08604664B2

    公开(公告)日：2013-12-10

    申请号：US13542179

    申请日：2012-07-05

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： H01L41/08

    CPC分类号： F03G7/005 ,  H01M10/052

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    摘要翻译： 本发明提供了涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

    Electrochemical actuators
    47.
    发明授权
    Electrochemical actuators 有权
    电化学执行机构

    公开(公告)号：US08368285B2

    公开(公告)日：2013-02-05

    申请号：US13328504

    申请日：2011-12-16

    申请人： Yet-Ming Chiang ,  Timothy E. Chin ,  Michael J. Cima ,  J. Richard Gyory

    发明人： Yet-Ming Chiang ,  Timothy E. Chin ,  Michael J. Cima ,  J. Richard Gyory

    IPC分类号： H91L41/08

    CPC分类号： H01M14/00 ,  F03G7/005 ,  H01M4/131 ,  H01M4/134 ,  H01M10/052 ,  H01M10/058

    摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.

    摘要翻译： 本文描述了用于提供电化学致动的装置和方法。 在一个实施例中，致动器装置包括包括负极和正极的电化学电池。负极的至少一部分由配制成插层，去插入，合金，氧化，还原的至少一种的材料形成 或者具有与正极的第二部分不同的程度的正极的第一部分的板，使得在正极的第一部分和第二部分之间施加微分应变，使得至少一部分 的电化学电池被移位。 电化学电池包括沿着电化学电池的轴线预弯曲以限定折叠轴线的部分，并且电化学电池的至少一部分的位移沿折叠轴线最大化。

    Method for operating microchip reservoir device
    49.
    发明授权
    Method for operating microchip reservoir device 有权
    操作微芯片储液装置的方法

    公开(公告)号：US07901397B2

    公开(公告)日：2011-03-08

    申请号：US11930406

    申请日：2007-10-31

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： A method is provided for operating a device for the containment and controlled release or exposure of a chemical substance. The method includes (i) providing a device which includes a substrate having a plurality of reservoirs, at least one chemical substance stored in the reservoirs, a plurality of metal reservoir caps, each of which closes an opening of one of said reservoir caps, and power and electrode means for disintegrating each of said reservoir caps; and (ii) disintegrating at least one of said reservoir caps, using said power and electrode means, to expose or release the chemical substance, wherein said disintegration comprises using potentiostatic or galvanostatic control to a voltage potential at said at least one reservoir cap.

    摘要翻译： 提供了一种用于操作用于化学物质的容纳和控制释放或暴露的装置的方法。 该方法包括（i）提供一种装置，其包括具有多个储存器的基板，存储在储存器中的至少一种化学物质，多个金属储存器盖，每个金属储存器盖封闭其中一个储存器盖的开口，以及 功率和电极装置，用于分解每个所述储存器盖; 以及（ii）使用所述功率和电极装置分解至少一个所述储存器盖以暴露或释放所述化学物质，其中所述分解包括对所述至少一个储存器盖的电压电位进行恒电位或恒电流控制。

    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
    50.
    发明授权
    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
    药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内

    公开(公告)号：US07875290B2

    公开(公告)日：2011-01-25

    申请号：US11246910

    申请日：2005-10-07

    申请人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    发明人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    IPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K9/48

    CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

    摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

    摘要翻译： 药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。 无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。 有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。 这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。 有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。