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41.发明申请NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS 有权新型吡咯烷衍生的BETA 3 ADRENERGIC RECEPTOR AGONISTS公开(公告)号：US20120225886A1
公开(公告)日：2012-09-06
申请号：US13392282
申请日：2010-08-24
申请人： Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gregori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
发明人： Scott D. Edmondson , Lehua Chang , Nam Fung Kar , Gregori J. Morriello , Christopher R. Moyes , Dong-Ming Shen , Cheng Zhu , Neville J. Anthony , Philip Jones , Graham F. Smith , Mark E. Scott , Christopher F. Thompson , Joon Jung , Carolyn Cammarano , Dawn Marie Hoffman
IPC分类号： A61K31/501 , A61K31/4196 , C07D401/12 , A61K31/4439 , A61K31/506 , A61K31/497 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , C07D471/04 , A61K31/437 , C07D207/04 , A61K31/40 , A61P13/10 , A61P13/02 , C07D403/12
CPC分类号： C07D401/12 , C07D207/08 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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42.发明授权Substituted pyrazoles, compositions containing such compounds and methods of use 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US07989475B2
公开(公告)日：2011-08-02
申请号：US12407184
申请日：2009-03-19
IPC分类号： A61K31/4155 , A61K31/445 , C07D231/10 , C07D401/04
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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43.发明申请SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US20090215825A1
公开(公告)日：2009-08-27
申请号：US12407184
申请日：2009-03-19
IPC分类号： A61K31/454 , C07D401/14 , A61K31/4439 , C07D401/04 , A61P3/10
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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44.发明授权Substituted pyrazoles, compositions containing such compounds and methods of use 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US07572922B2
公开(公告)日：2009-08-11
申请号：US10543290
申请日：2004-01-23
IPC分类号： C07D257/00 , C07D231/10 , A01N43/64 , A01N43/56
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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公开(公告)号：US20080032951A1
公开(公告)日：2008-02-07
申请号：US11630172
申请日：2005-07-15
申请人： James Doherty , Dong-Ming Shen
发明人： James Doherty , Dong-Ming Shen
IPC分类号： A61K31/675 , A61P25/24 , A61P25/28 , A61P27/02 , C07F9/09
CPC分类号： C07D231/56 , C07F9/65038
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US5369213A
公开(公告)日：1994-11-29
申请号：US83850
申请日：1993-06-30
申请人： Dong-Ming Shen
发明人： Dong-Ming Shen
CPC分类号： C07C2/76 , C07C2527/125 , C07C2527/126 , C07C2527/128 , C07C2527/135 , C07C2527/138
摘要： The present invention provides a method for arylating a diamondoid compound having at least one unsubstituted bridgehead carbon with an aromatic compound having at least one unsubstituted ring-member carbon comprising reacting said diamondoid compound with said aromatic compound in the presence of an olefin and a catalytically effective amount of a Lewis acid.
摘要翻译： 本发明提供了一种使具有至少一个未取代桥头碳的金刚石化合物芳基化的方法，其中芳族化合物具有至少一个未取代的环成员碳，包括在烯烃存在下使所述金刚石类化合物与所述芳族化合物反应并具有催化效果 路易斯酸的量。
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47.发明授权Method for making diamondoid lubricant base stock by alkylation with an olefin in the presence of a Lewis acid 失效在路易斯酸存在下用烯烃烷基化制备金刚石润滑剂基础油料的方法
公开(公告)号：US5345020A
公开(公告)日：1994-09-06
申请号：US70823
申请日：1993-06-03
申请人： Dong-Ming Shen , Margaret M. Wu
发明人： Dong-Ming Shen , Margaret M. Wu
CPC分类号： C07C2/54 , C07C2103/74 , C07C2527/08 , C07C2527/125
摘要： The invention provides a method for selectively alkylating a diamondoid compound comprising reacting at least one .alpha.-olefin containing at least six carbon atoms with at least one diamondoid compound in the presence of an acid catalyst selected from the group consisting of AlX.sub.3 and BX.sub.3 wherein X is a halogen, in the absence of added proton-donating catalyst promoter. The invention further provides a lubricant composition comprising alkyl-substituted adamantanes wherein the ratio of linear to branched alkyl substituents is at least about 4:1 and wherein the average number of alkyl substitutions per diamondoid molecule is from about 1.5 to about 4.
摘要翻译： 本发明提供了选择性烷基化金刚石化合物的方法，包括使至少一种含有至少6个碳原子的α-烯烃与至少一种类金刚石化合物在选自AlX 3和BX 3的酸催化剂存在下反应，其中X为 在没有添加质子递送催化剂促进剂的情况下是卤素。 本发明还提供了包含烷基取代的金刚烷的润滑剂组合物，其中直链与支链烷基取代基的比例为至少约4:1，并且其中每个金刚石类分子的平均烷基取代数为约1.5至约4。
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公开(公告)号：US5334228A
公开(公告)日：1994-08-02
申请号：US137539
申请日：1993-10-18
CPC分类号： C10L1/143 , C10L10/06 , C10L1/1608 , C10L1/1616 , C10L1/1641 , C10L1/1683 , C10L1/18 , C10L1/1817 , C10L1/19 , C10L1/1905 , C10L1/192 , C10L1/198 , C10L1/1985 , C10L1/221 , C10L1/2222 , C10L1/2225 , C10L1/2227 , C10L1/224 , C10L1/232 , C10L1/233 , C10L1/238 , C10L1/2383 , C10L1/2387 , C10L1/2475 , C10L1/2691 , C10L1/303
摘要： A fuel additive having detergency, solubility and thermal stability comprises a detergent component, e.g., polyalkenyl succinimide, and a carrier fluid obtained from a diamondoid fluid comprising an compound selected from the group consisting of adamantane, diamantane, triamantane, tetramantane, and the alkyl-substituted derivatives thereof.
摘要翻译： 具有洗涤性，溶解性和热稳定性的燃料添加剂包括洗涤剂组分，例如聚链烯基琥珀酰亚胺和从包含选自金刚烷，二金刚烷，三金刚烷，四聚烷烃和烷基 - 取代的衍生物。
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公开(公告)号：US20130217660A1
公开(公告)日：2013-08-22
申请号：US13642584
申请日：2011-05-12
IPC分类号： C07C237/24 , C07D295/155 , A61K31/165 , C07D213/40 , A61K31/5377 , C07D241/12 , C07D239/26 , A61K31/397 , C07D205/04 , A61K31/4453 , A61K31/40 , C07D233/61 , A61K31/4164 , A61K45/06 , C07C271/24 , C07D213/61 , A61K31/5375
CPC分类号： C07C237/24 , A61K31/165 , A61K31/397 , A61K31/40 , A61K31/4164 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K45/06 , C07C271/24 , C07C2601/02 , C07C2601/14 , C07D205/04 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/85 , C07D233/56 , C07D233/61 , C07D239/26 , C07D241/12 , C07D295/15 , C07D295/155
摘要： Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
摘要翻译： 结构式I的化合物是脯氨酰羧肽酶（PrCP）的抑制剂。 本发明的化合物可用于预防和治疗与PrCP的酶活性相关的病症，例如异常代谢，包括肥胖症; 糖尿病; 代谢综合征; 肥胖相关疾病; 和糖尿病相关疾病。
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公开(公告)号：US08247415B2
公开(公告)日：2012-08-21
申请号：US12417239
申请日：2009-04-02
申请人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
发明人： Richard Berger , Lehua Chang , Scott D. Edmondson , Stephen D. Goble , Sookhee Nicole Ha , Nam Fung Kar , Ihor E. Kopka , Bing Li , Gregori J. Morriello , Chris R. Moyes , Dong-Ming Shen , Liping Wang , Cheng Zhu
IPC分类号： C07D237/30 , C07D239/90 , C07D221/02 , C07D277/60 , A61K31/502 , A61K31/517 , A61K31/435 , A61K31/428 , A61P13/10 , A61P13/06
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）化合物，其药物组合物及其用于治疗或预防由β-肾上腺素能受体激活介导的疾病的方法。
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