公开(公告)号：US4259572A

公开(公告)日：1981-03-31

申请号：US39478

申请日：1979-05-16

申请人： Curt Brunnee ,  Jochen Franzen ,  Stefan Meier

发明人： Curt Brunnee ,  Jochen Franzen ,  Stefan Meier

IPC分类号： G01N27/68 ,  G01N30/02 ,  G01N30/84 ,  H01J49/04 ,  H01J49/14 ,  H05H3/02 ,  H01J27/00 ,  B01D59/44

CPC分类号： H01J49/0431 ,  G01N27/68 ,  H01J49/049 ,  H01J49/142 ,  H05H3/02 ,  G01N2030/027 ,  G01N2030/8417 ,  G01N35/00009

摘要： Organic samples from a liquid chromatograph are deposited on a conveyor belt which transports them into a vacuum chamber at the entry end of a mass spectrometer. The samples are ionized directly on the belt by particle bombardment or by means of a laser beam. Ionization is enhanced by applying an oxide layer to the belt, by neutralizing the image force, and by vaporizing alkali atoms on the belt to reduce the ionization potential.

摘要翻译： 来自液相色谱仪的有机样品沉积在传送带上，将其输送到质谱仪入口端的真空室中。 通过粒子轰击或通过激光束将样品直接电离在带上。 通过将氧化层施加到带上，通过中和图像力以及通过汽化带上的碱原子来降低电离电位来提高电离。

公开(公告)号：US08410429B2

公开(公告)日：2013-04-02

申请号：US13017803

申请日：2011-01-31

申请人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

IPC分类号： H01J49/06 ,  H01J49/36

CPC分类号： H01J49/4205 ,  H01J49/062

摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.

摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。

公开(公告)号：US08368012B2

公开(公告)日：2013-02-05

申请号：US12699550

申请日：2010-02-03

申请人： Evgenij Nikolaev ,  Jochen Franzen

发明人： Evgenij Nikolaev ,  Jochen Franzen

IPC分类号： H01J49/10 ,  H01J27/02 ,  H01J3/14

CPC分类号： H01J37/248 ,  H01J49/062 ,  H01J49/165 ,  H01J2237/03

摘要： Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter.

摘要翻译： 带电喷雾液滴由引导装置的电极处的音频电压产生的赝势分布引导，将喷雾液滴聚焦到轴上。 引导装置中的干燥气体的轴向电场分布和轴向流动分布允许不同尺寸的液滴在引导装置的纵向方向上的漂移被控制，使得当它们离开时液滴大小相当大小 引导装置，最后在离开后立即干燥。 结果，离子形成在较小的空间区域。 静电势将分析离子从该小空间区域引导到入口毛细管的入口孔; 在此过程中，非常轻的离子，特别是质子和水 - 质子复合物可以通过迁移率过滤器过滤掉。

公开(公告)号：US20120273674A1

公开(公告)日：2012-11-01

申请号：US13094146

申请日：2011-04-26

申请人： Melvin Andrew Park ,  Jochen Franzen

发明人： Melvin Andrew Park ,  Jochen Franzen

IPC分类号： H01J49/26 ,  H01J49/10

CPC分类号： G01N27/626

摘要： In an ion mobility spectrometer in which a gas pushes ions along a spectrometer axis against and over an electrical field barrier, the electric field barrier is generated with a plateau of slightly increasing height along the axis of the spectrometer. Alternately, the electric filed barrier may have a plateau with constant height, but the gas flow decreases in velocity along the axis of the spectrometer in the vicinity of the plateau.

摘要翻译： 在离子迁移谱仪中，其中气体沿着光谱仪轴线推动离子抵抗和超过电场屏障，电场屏障是沿着光谱仪轴线的高度稍微增加的高原产生的。 或者，电场屏障可以具有恒定高度的平台，但气流在平台附近沿着光谱仪的轴线的速度减小。

公开(公告)号：US20110062322A1

公开(公告)日：2011-03-17

申请号：US12883885

申请日：2010-09-16

申请人： Jochen Franzen

发明人： Jochen Franzen

IPC分类号： B01D59/44 ,  G01N27/62

CPC分类号： G01N27/622

摘要： A supersonic gas jet having gas molecules with substantially equal velocities is formed by directing the gas through a Laval nozzle into an evacuated chamber. A field barrier having a substantially constant height across a cross-section of the supersonic gas jet is formed by respectively applying potentials U2, U3 and U4 to an arrangement of three apertured diaphragms R2, R3 and R4, which are respectively separated by distances d2 and d3, where (U4−U3)/(U3−U2)=d3/d2. The ions in the supersonic gas jet are directed against the field barrier, where ions with a mobility below a mobility threshold are pushed over the field barrier, and where ions with a mobility higher than the mobility threshold are held back by the field barrier.

摘要翻译： 具有基本相同速度的气体分子的超音速气体射流通过将气体通过拉瓦尔喷嘴引导到抽空的室中而形成。 通过分别将电位U2，U3和U4施加到三个有孔隔膜R2，R3和R4的排列上，形成跨超声波气体射流横截面具有基本恒定高度的场屏障，它们分别以距离d2和 d3，其中（U4-U3）/（U3-U2）= d3 / d2。 超音速气体射流中的离子被引导到场屏障，其中迁移率低于迁移率阈值的离子被推到场屏障上，并且其中迁移率高于迁移率阈值的离子被场屏障阻挡。

公开(公告)号：US20110039350A1

公开(公告)日：2011-02-17

申请号：US12853637

申请日：2010-08-10

申请人： Jochen Franzen

发明人： Jochen Franzen

IPC分类号： G01N1/00 ,  H01J49/04 ,  H01J49/14 ,  H01J49/16 ,  H01J49/10 ,  H01J49/12 ,  B01J19/08

CPC分类号： H01J49/0431 ,  Y10T436/25

摘要： Gaseous analyte molecules are ionized at atmospheric pressure and provided to an inlet capillary of an ion spectrometer vacuum system by passing the ions through a reaction tube that ends in a conical intermediate piece for a gastight and smooth transition into the inlet capillary. The reaction tube is shaped so that the atmospheric pressure gas stream passing therethrough form the entrance of the tune to the intermediate piece is stably laminar. Analyte molecules from gas chromatographs, spray devices or vaporization devices can be introduced into the entrance of the reaction tube and ionized within the tube by single- or multi-photon ionization, by chemical ionization, by reactant ions or by physical ionization. For single- or multi-photon ionization, a beam from a laser can be passed axially down the reaction tube. Reactant ions can be produced by any means outside of the reaction tube and mixed with the analyte molecules within the tube.

摘要翻译： 气态分析物分子在大气压下离子化，并通过使离子通过端接在锥形中间件中的反应管提供给离子光谱仪真空系统的入口毛细管，以便气密和平滑过渡到入口毛细管中。 反应管成形为使得通过其的大气压力气流形成曲调到中间件的入口是稳定的层流的。 来自气相色谱仪，喷雾装置或蒸发装置的分析物分子可以通过单光子或多光子电离，通过化学电离，反应物离子或物理电离引入反应管的入口并离子化。 对于单光子或多光子电离，来自激光束的光束可以沿着反射管轴向通过。 反应物离子可以通过反应管外的任何方式产生并与管内的分析物分子混合。

公开(公告)号：US20110036974A1

公开(公告)日：2011-02-17

申请号：US12857161

申请日：2010-08-16

申请人： Jochen Franzen ,  Claus Köster

发明人： Jochen Franzen ,  Claus Köster

IPC分类号： H01J49/04

CPC分类号： H01J49/062 ,  H01J49/0445

摘要： Charged droplets are guided along a defined path from a droplet source to a droplet sink. A focusing pseudopotential distribution generated by audio frequencies on electrodes of a guiding device guide the charged droplets from the droplet source to the droplet sink with low loss. The droplets can be driven along the droplet guide by a gas flow, an axial electric field or a combination of both. For example, charged droplets from a spray capillary of an electrospray ion source at atmospheric pressure may be introduced into the inlet capillary leading to the vacuum system of ion analyzers, a procedure similar to that used up to now in nanoelectrospraying, but with substantially higher flow rates. In the guiding device, the droplets can be manipulated in different ways, for example evaporated down to a desired size. The introduction of small droplets into gas-aspirating capillaries is of interest because it is possible to keep the droplets on axis by Bernoulli focusing and to guide them in large quantities and with low loss through the capillary. The ability to guide the droplets makes it also possible to install a segmented inlet capillary with intermediate pumping, which allows pumping capacity to be saved. Advantageously, the sensitivity of ion analyzers such as mass spectrometers or ion mobility spectrometers by at least one order of magnitude.

摘要翻译： 带电液滴沿着从液滴源到液滴槽的限定路径被引导。 由引导装置的电极上的音频产生的聚焦伪势分布将带电液滴从液滴源引导到具有低损耗的液滴槽。 液滴可以通过气流，轴向电场或两者的组合沿液滴引导件驱动。 例如，在大气压下来自电喷雾离子源的喷雾毛细管的带电液滴可以引入入口毛细管中，导入离子分析仪的真空系统，该方法与迄今为止在纳电电喷雾中使用的方法类似，但具有显着更高的流动 价格。 在引导装置中，液滴可以以不同的方式进行操作，例如蒸发到所需尺寸。 将小液滴引入吸气毛细管是令人感兴趣的，因为可以通过伯努利聚焦将液滴保持在轴上，并且通过毛细管大量引导并以低损耗引导。 引导液滴的能力使得还可以安装具有中间泵送的分段入口毛细管，这允许节省泵送能力。 有利地，诸如质谱仪或离子迁移谱仪的离子分析仪的灵敏度至少有一个数量级。

公开(公告)号：US20100224775A1

公开(公告)日：2010-09-09

申请号：US12716813

申请日：2010-03-03

申请人： Andreas Haase ,  Jens Höhndorf ,  Jochen Franzen

发明人： Andreas Haase ,  Jens Höhndorf ,  Jochen Franzen

IPC分类号： H01J49/26 ,  H01J49/02

CPC分类号： H01J49/164 ,  H01J49/0045

摘要： Mass spectrometry with lasers generates ions from analyte molecules by matrix assisted laser desorption for a variety of different mass spectrometric analysis procedures. The mass spectrometers with laser systems supply laser light pulses having at least two different pulse durations, and mass spectrometric measuring techniques use the laser light pulses of different durations. The duration of the laser light pulses allows the characteristics of the ionization of the analyte molecules, particularly the occurrence of the ISD (in-source decay) and PSD (post-source decay) types of fragmentation, whose fragment ion spectra supply different kinds of information, to be adapted to the analytic procedure.

摘要翻译： 使用激光的质谱法通过基质辅助激光解吸从分析物分子产生离子，用于各种不同的质谱分析程序。 具有激光系统的质谱仪提供具有至少两个不同脉冲持续时间的激光脉冲，并且质谱测量技术使用不同持续时间的激光脉冲。 激光脉冲的持续时间允许分析物分子的电离特性，特别是ISD（源内衰变）和PSD（后源衰变）类型的断裂的出现，其碎片离子谱提供不同种类的 信息，以适应分析程序。

公开(公告)号：US07595486B2

公开(公告)日：2009-09-29

申请号：US11691166

申请日：2007-03-26

申请人： Jochen Franzen

发明人： Jochen Franzen

IPC分类号： H01J49/04

CPC分类号： H01J49/065 ,  H01J49/063

摘要： In a multipole rod ion guide system operated with RF voltages to collect or transmit ions, the inhomogeneity of the electric RF fields is increased in front of the ion guide rods by forming the rod surfaces from a plurality of spaced electrodes. The inhomogeneous fields produced by the plurality of electrodes increases the mass range over which the ions are guided effectively while still maintaining a pseudopotential minimum which is as well defined as possible close to the axis. Particularly favorable ion guides of this type make it possible to apply an axial DC field to the guide system for the active transport of the ions.

摘要翻译： 在用RF电压操作以收集或传输离子的多极杆离子导向系统中，通过从多个间隔开的电极形成杆表面，在离子导杆的前方增加了电RF场的不均匀性。 由多个电极产生的不均匀场增加离子被有效引导的质量范围，同时仍保持尽可能靠近轴线限定的赝势最小值。 这种特别有利的离子导向器使得可以将轴向DC场施加到导向系统以有源输送离子。

公开(公告)号：US07399640B2

公开(公告)日：2008-07-15

申请号：US10828153

申请日：2004-04-20

申请人： Martin Schürenberg ,  Jochen Franzen

发明人： Martin Schürenberg ,  Jochen Franzen

IPC分类号： G01N24/00 ,  B01J19/08 ,  H01J49/40

CPC分类号： H01J49/0418 ,  B01L3/5085 ,  G01N1/40 ,  Y10T436/11 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/2575

摘要： The invention relates to sample support plates with hydrophilic anchors in a strongly hydrophobic environment for mass spectroscopic analysis of biosubstances with ionization by matrix-assisted laser desorption and ionization (MALDI), procedures for manufacturing these sample supports, and connected procedures for loading these sample supports with biomolecular samples. The invention provides areas with affinity adsorbents adjacent to the hydrophilic anchors for purifying biosubstances and, if wanted, for performing an affinity selection of biosubstances, whereby the finally prepared matrix sample crystals with the biosubstances for the MALDI analysis are well localized on the hydrophilic anchors.

摘要翻译： 本发明涉及在强疏水环境中具有亲水性锚定物的样品支撑板，用于通过基质辅助激光解吸和电离（MALDI）进行离子化生物物质的质谱分析，制备这些样品载体的方法以及用于加载这些样品载体的连接方法 与生物分子样品。 本发明提供了亲水性吸附剂的邻近亲水性锚定物的区域，用于纯化生物条件，并且如果需要，进行生物物质的亲和选择，由此最终制备的具有用于MALDI分析的生物基质的基质样品晶体很好地定位在亲水性锚定体上。